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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 11,951–11,975 of 27,380 studies, newest first · page 479 of 1096.

January 2020 25

  1. 2020-01-30

    Benzothiazole amphiphiles promote RasGRF1-associated dendritic spine formation in human stem cell-derived neurons

    ✓ Peer-reviewed Disease mechanisms FEBS open bio

    Key finding: While these results represent a good first step in exploring a new approach to treating NDDs, the capability of these compounds to increase spine density has not been previously examined in a human neuronal model. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2020-01-30

    Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's disease

    ✓ Peer-reviewed TREM2 and immune genetics Brain, behavior, and immunity

    Key finding: We examined changes in peripheral innate immune-related markers in PD cases (n = 41) stratified according to risk of developing early dementia. 'Higher Risk'(HR) (n = 23) and 'Lower Risk' (LR) (n = 18) groups were defined according to neuropsychological predictors and MAPT H1/H2 genotype, and compared to age, gender and genotype-matched controls. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2020-01-30

    Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives

    ✓ Peer-reviewed Mild cognitive impairment Frontiers in aging neuroscience

    Key finding: MCI patients have a high prevalence of depression/anxiety/apathy; furthermore, patients with MCI and concomitant depression/anxiety/apathy have more pronounced cognitive deficits and progress more often to dementia than MCI patients without depression/anxiety/apathy. +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2020-01-30

    Elevated methylation levels, reduced expression levels, and frequent contractions in a clinical cohort of C9orf72 expansion carriers

    ✓ Peer-reviewed Digital health tools Molecular neurodegeneration

    Key finding: In blood from C9orf72 expansion carriers, we found elevated methylation levels, reduced expression levels, and unstable expansions that tend to contract in successive generations, arguing against anticipation. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2020-01-30

    Glycogen synthase kinase-3 signaling in Alzheimer's disease

    ✓ Peer-reviewed Caregiving Biochimica et biophysica acta. Molecular cell research

    Key finding: Currently, 5.8 million people in the U.S. are living with AD and by 2050 this number is expected to double resulting in a significant socio-economic burden. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2020-01-30

    Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer-like behavioral and neuropathological changes in CD-1 mice

    ✓ Peer-reviewed Biomarkers Brain and behavior

    Key finding: Prenatal exposure to low doses of LPS caused AD-related features including behavioral and neuropathological changes from midlife to senectitude. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2020-01-29

    Interplay Between Mitochondrial Oxidative Disorders and Proteostasis in Alzheimer's Disease

    ✓ Peer-reviewed Disease mechanisms Frontiers in neuroscience

    Key finding: OS refers to an imbalance between oxidant and antioxidant systems, which usually consist in an overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS) which overwhelms the intrinsic antioxidant defenses. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2020-01-29

    A Proteotranscriptomic-Based Computational Drug-Repositioning Method for Alzheimer's Disease

    ✓ Peer-reviewed Drug development Frontiers in pharmacology

    Key finding: The DRPS/C method was evaluated using the area under the ROC curve, with a prescribed drug list from TCGA as the gold standard. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2020-01-29

    Genome-Wide Association Study of Brain Connectivity Changes for Alzheimer's Disease

    ✓ Peer-reviewed Genetics Scientific reports

    Key finding: Genome-wide association studies (GWAS) have identified genetic loci that significantly contribute to the risk of Alzheimers. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2020-01-29

    Plasma Neurofilament Light Chain May Be a Biomarker for the Inverse Association Between Cancers and Neurodegenerative Diseases

    ✓ Peer-reviewed Biomarkers Frontiers in aging neuroscience

    Key finding: We found that GC subjects expressed lower plasma NfL levels but AD subjects expressed higher plasma NfL levels than NCs. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2020-01-29

    ATP13A2 deficiency disrupts lysosomal polyamine export

    ✓ Peer-reviewed Brain tissue and pathology Nature

    Key finding: ATP13A2 offers protection against genetic and environmental risk factors of Parkinson's disease, whereas loss of ATP13A2 compromises lysosomes 3 . +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2020-01-29

    Dietary flavonols and risk of Alzheimer dementia

    ✓ Peer-reviewed Genetics Neurology

    Key finding: Higher dietary intakes of flavonols may be associated with reduced risk of developing Alzheimer dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2020-01-27

    Metformin and trimetazidine ameliorate diabetes-induced cognitive impediment in status epileptic rats

    ✓ Peer-reviewed Drug development Epilepsy & behavior : E&B

    Key finding: In conclusion, the current study shed light on the potential neuroprotective role of metformin and trimetazidine in the amelioration of cognitive function via hindering inflammatory processes in diabetic epileptic rats.

    Full summary, score breakdown and related studies → Original source

  14. 2020-01-26

    Modelling prognostic trajectories of cognitive decline due to Alzheimer's disease

    ✓ Peer-reviewed Long-term cohort studies NeuroImage. Clinical

    Key finding: However, not all individuals with MCI develop dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2020-01-25

    Prospective Associations Between Diffusion Tensor Imaging Parameters and Frailty in Older Adults

    ✓ Peer-reviewed Treatments Journal of the American Geriatrics Society

    Key finding: This is the first study to show that WM integrity is associated with frailty in older adults. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2020-01-24

    Intracellular Calcium Dysregulation by the Alzheimer's Disease-Linked Protein Presenilin 2

    ✓ Peer-reviewed Risk genes beyond APOE International journal of molecular sciences

    Key finding: AD mutations contribute to the generation of toxic amyloid β (Aβ) peptides and the formation of cerebral plaques, leading to the formulation of the amyloid cascade hypothesis for AD pathogenesis. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2020-01-24

    Interpretation of risk loci from genome-wide association studies of Alzheimer's disease

    ✓ Peer-reviewed Genetics The Lancet. Neurology

    Key finding: This situation presents difficulties for experimental studies, drug development, and other future research. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2020-01-24

    Gallery Game: Smartphone-based assessment of long-term memory in adults at risk of Alzheimer's disease

    ✓ Peer-reviewed Cognitive tests and assessment Journal of clinical and experimental neuropsychology

    Key finding: Retention intervals of at least three days were needed to evidence significant forgetting at both recognition and paired-associate recall test. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2020-01-24

    Virtual Reality for Therapeutic Recreation in Dementia Hospice Care: A Feasibility Study

    ✓ Peer-reviewed End-of-life care The American journal of hospice & palliative care

    Key finding: Virtual reality use was generally safe and enjoyable in hPLWD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  20. 2020-01-24

    Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model

    ✓ Peer-reviewed TREM2 and immune genetics The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: To study the role of Trem2 in a mouse model of β-amyloidosis, we compared PS2APP transgenic mice versus PS2APP mice lacking Trem2 (PS2APP;Trem2 ko ) at ages ranging from 4 to 22 months. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2020-01-24

    Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Neurobiology of disease

    Key finding: This phenomenon, known as brain insulin resistance, is associated with poor cognitive performance and is driven by the uncoupling of insulin receptor (IR) from its direct substrate (IRS1). +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2020-01-23

    Cognitive Reserve Is Not Associated With Hippocampal Microstructure in Older Adults Without Dementia

    ✓ Peer-reviewed Risk factors Frontiers in aging neuroscience

    Key finding: CR was not associated with hippocampal GM MD and hippocampal GM volume. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2020-01-23

    The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly

    ✓ Peer-reviewed Long-term cohort studies Nature communications

    Key finding: Here we describe the first release of the Medical Genome Reference Bank (MGRB), comprising whole genome sequence and phenotype of 2570 elderly Australians depleted for cancer, cardiovascular disease, and dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2020-01-22

    Community-Based Palliative Care Consultations: Comparing Dementia to Nondementia Serious Illnesses

    ✓ Peer-reviewed End-of-life care Journal of palliative medicine

    Key finding: Of 3883 older adults receiving a first palliative care consultation from this organization, 22% (855) had a dementia diagnosis. +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2020-01-22

    Differential neurocognitive network perturbation in amnestic and aphasic Alzheimer disease

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: Despite the presumptive common underlying neuropathology of amyloid plaques and neurofibrillary tangles, the 2 groups displayed 2 different patterns of network perturbation, each concordant with the clinical presentation and the anatomy of neurodegeneration. +1 more finding

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →