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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 9,651–9,675 of 27,380 studies, newest first · page 387 of 1096.

November 2021 6

  1. 2021-11-01

    Acupuncture for amnestic mild cognitive impairment: A pilot multicenter, randomized, parallel controlled trial

    ✓ Peer-reviewed Treatments Medicine

    Key finding: This pilot trial aims to explore the feasibility of the trial, verify essential information of its efficacy and safety. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2021-11-01

    Effect of Methylphenidate on Apathy in Patients With Alzheimer Disease: The ADMET 2 Randomized Clinical Trial

    ✓ Peer-reviewed Treatments JAMA neurology

    Key finding: Of 200 participants, 99 were assigned to methylphenidate and 101 to placebo. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2021-11-01

    Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity: A Randomized Clinical Trial

    ✓ Peer-reviewed Treatments JAMA neurology

    Key finding: Of 54 adults assessed for eligibility, 11 did not meet study criteria, and 9 declined to participate. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2021-11-01

    Astrocyte activation imaging with 11C-acetate and amyloid PET in mild cognitive impairment due to Alzheimer pathology

    ✓ Peer-reviewed Biomarkers Nuclear medicine communications

    Key finding: MTL 11C-acetate SUVR was significantly elevated in MCI compared to cognitively normal participants (P = 0.03; Cohen d = 1.76). +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2021-11-01

    Development of a Plasma Biomarker Diagnostic Model Incorporating Ultrasensitive Digital Immunoassay as a Screening Strategy for Alzheimer Disease in a Chinese Population

    ✓ Peer-reviewed Biomarkers Clinical chemistry

    Key finding: We established AD diagnostic models using plasma biomarkers for Chinese participants. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2021-11-01

    Dementia with Lewy bodies: association of Alzheimer pathology with functional connectivity networks

    ✓ Peer-reviewed Biomarkers Brain : a journal of neurology

    Key finding: This was then correlated with overall cortical flortaucipir PET and PiB PET standardized uptake value ratio (SUVr). +4 more findings

    Full summary, score breakdown and related studies → Original source

October 2021 19

  1. 2021-10-31

    Alzheimer's disease related biomarkers in bipolar disorder - A longitudinal one-year case-control study

    ✓ Peer-reviewed Biomarkers Journal of affective disorders

    Key finding: Levels of CSF Aβ42 decreased in patients with BD who had an episode during follow-up (BD-E) (N = 22) compared to patients without an episode (BD-NE) (N = 25) during follow-up (P = 0.002). +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2021-10-31

    Prediabetes and risk of mortality, diabetes-related complications and comorbidities: umbrella review of meta-analyses of prospective studies

    ✓ Peer-reviewed Risk factors Diabetologia

    Key finding: Prediabetes was positively associated with risk of all-cause mortality and the incidence of cardiovascular outcomes, CHD, stroke, chronic kidney disease, cancer and dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2021-10-30

    A drug repositioning algorithm based on a deep autoencoder and adaptive fusion

    ✓ Peer-reviewed Drug development BMC bioinformatics

    Key finding: In this study, a drug repositioning algorithm based on a deep autoencoder and adaptive fusion was proposed to mitigate the problems of decreased precision and low-efficiency multisource data fusion caused by data sparseness. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-10-30

    Diagnostic performance of digital cognitive tests for the identification of MCI and dementia: A systematic review

    ✓ Peer-reviewed Digital health tools Ageing research reviews

    Key finding: Digital cognitive tests showed good performances for MCI and dementia.

    Full summary, score breakdown and related studies → Original source

  5. 2021-10-29

    Association between WWOX/MAF variants and dementia-related neuropathologic endophenotypes

    ✓ Peer-reviewed Genetics Neurobiology of aging

    Key finding: We hypothesized that the WWOX/MAF locus may be preferentially associated with non-plaque- and non-tau-related neuropathological changes (NC). +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2021-10-29

    Plasma neurofilament L to amyloid β42 ratio in differentiating Alzheimer's type from non-Alzheimer's dementia: A cross-sectional pilot study from India

    ✓ Peer-reviewed Biomarkers Asian journal of psychiatry

    Key finding: Based on the reduction of amyloid β plaques, US FDA has recently approved Aducanumab as a disease modifying treatment for Alzheimer's disease (AD).

    Full summary, score breakdown and related studies → Original source

  7. 2021-10-29

    In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease

    ✓ Peer-reviewed Brain scans and imaging Science advances

    Key finding: Our results suggest that from Braak stage III onward, local replication, rather than spreading between brain regions, is the main process controlling the overall rate of accumulation of tau in neocortical regions.

    Full summary, score breakdown and related studies → Original source

  8. 2021-10-29

    Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimer's disease: A meta-analysis of in vivo magnetic resonance spectroscopy studies

    ✓ Peer-reviewed Mild cognitive impairment Ageing research reviews

    Key finding: Accumulating evidence demonstrates that metabolic changes in the brain associated with neuroinflammation, oxidative stress, and mitochondrial dysfunction play an important role in the pathophysiology of mild cognitive impairment (MCI) and Alzheimer's disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2021-10-29

    Environmental factors and risks of cognitive impairment and dementia: A systematic review and meta-analysis

    ✓ Peer-reviewed Disparities Ageing research reviews

    Key finding: This review highlights that air pollutions, especially PM 2.5 and NO 2 play important role in the risk for age-related cognitive impairment and dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2021-10-28

    Age-related immune alterations and cerebrovascular inflammation

    ✓ Peer-reviewed Vascular contributions Molecular psychiatry

    Key finding: Aging is associated with chronic systemic inflammation, which contributes to the development of many age-related diseases, including vascular disease.

    Full summary, score breakdown and related studies → Original source

  11. 2021-10-27

    Using Digital Speech Assessments to Detect Early Signs of Cognitive Impairment

    ✓ Peer-reviewed Cognitive tests and assessment Frontiers in digital health

    Key finding: Most of the current screening tools for Alzheimer's Disease represent a significant burden, requiring invasive procedures, or intensive and costly clinical testing. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2021-10-27

    Genomics of Alzheimer's disease implicates the innate and adaptive immune systems

    ✓ Peer-reviewed TREM2 and immune genetics Cellular and molecular life sciences : CMLS

    Key finding: Over 130 AD-associated susceptibility loci have been identified by genome-wide association studies (GWAS), while whole genome sequencing (WGS) and whole exome sequencing (WES) studies have identified AD-associated rare variants. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2021-10-26

    Population pharmacokinetics and standard uptake value ratio of aducanumab, an amyloid plaque–removing agent, in patients with Alzheimer’s disease

    ✓ Peer-reviewed Treatments CPT: Pharmacometrics & Systems Pharmacology

    Key finding: The PopPK‐PD model showed that magnitude, duration, and consistency of dosing are important factors determining the degree of Aβ removal.

    Full summary, score breakdown and related studies → Original source

  14. 2021-10-26

    Representativeness of Participants Eligible to Be Enrolled in Clinical Trials of Aducanumab for Alzheimer Disease Compared With Medicare Beneficiaries With Alzheimer Disease and Mild Cognitive Impairment

    ✓ Peer-reviewed Costs and economics JAMA

    Key finding: This study evaluates whether patients enrolled in trials of aducanumab, EMERGE and ENGAGE, were representative of patients with dementia enrolled in Medicare by estimating the proportions of Medicare beneficiaries with Alzheimer disease (AD) or mild cognitive impairment (MCI) who would have been excluded from these trials.

    Full summary, score breakdown and related studies → Original source

  15. 2021-10-26

    Caregiver Burden in a Culturally Diverse Memory Clinic Population: The Caregiver Strain Index-Expanded

    ✓ Peer-reviewed Caregiving Dementia and geriatric cognitive disorders

    Key finding: Informal caregivers in the multicultural memory clinic cohort experienced a high level of caregiver burden (mean CSI-score multicultural cohort: 6.1 [SD: 3.3]; mean CSI-score native Dutch cohort: 4.8 [SD: 3.2]). +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2021-10-26

    Disentangling Mitochondria in Alzheimer's Disease

    ✓ Peer-reviewed Clinical safety International journal of molecular sciences

    Key finding: Aβ plaques and hyperphosphorylated tau aggregates, along with cognitive deficits and behavioral problems, are the hallmarks of the disease. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2021-10-26

    Development of the First WHO Guidelines for Risk Reduction of Cognitive Decline and Dementia: Lessons Learned and Future Directions

    ✓ Peer-reviewed Prevention trials Frontiers in neurology

    Key finding: The evidence collected indicates that multidomain approaches targeting simultaneously multiple risk factors and tailored at both individual and population level, are likely to be most effective and feasible in dementia risk reduction. +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2021-10-26

    Implications of Phosphoinositide 3-Kinase-Akt (PI3K-Akt) Pathway in the Pathogenesis of Alzheimer's Disease

    ✓ Peer-reviewed Disease mechanisms Molecular neurobiology

    Key finding: Furthermore, experimental data indicate that PI3K-Akt signaling might be an important therapeutic target in treatment of AD.

    Full summary, score breakdown and related studies → Original source

  19. 2021-10-26

    Relationship between Residential Segregation, Later-Life Cognition, and Incident Dementia across Race/Ethnicity

    ✓ Peer-reviewed Disparities International journal of environmental research and public health

    Key finding: Systemic racism leads to racial/ethnic residential segregation, which can result in health inequities. +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →