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Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer's Disease
Khan S, Barve KH, Kumar MS.. Current neuropharmacology, 2020-01-01
Topic: Amyloid, tau and blood-test diagnosis
Background The only conclusive way to diagnose Alzheimer's is to carry out brain autopsy of the patient's brain tissue and ascertain whether the subject had Alzheimer's or any other form of dementia. However, due to the non-feasibility of such methods, to diagnose and conclude the conditions, medical practitioners use tests that examine a patient's mental ability. Objective Accurate diagnosis at an early stage is the need of the hour for initiation of therapy. The cause for most Alzheimer's cases still remains unknown except where genetic distinctions have been observed. Thus, a standard drug regimen ensues in every Alzheimer's patient, irrespective of the cause, which may not always be beneficial in halting or reversing the disease progression. To provide a better life to such patients by suppressing existing symptoms, early diagnosis, curative therapy, site-specific delivery of drugs, and application of hyphenated methods like artificial intelligence need to be brought into the main field of Alzheimer's therapeutics. Methods In this review, we have compiled existing hypotheses to explain the cause of the disease, and highlighted gene therapy, immunotherapy, peptidomimetics, metal chelators, probiotics and quantum dots as advancements in the existing strategies to manage Alzheimer's. Conclusion Biomarkers, brain-imaging, and theranostics, along with artificial intelligence, are understood to be the future of the management of Alzheimer's.
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APA 7th
Khan, S., Barve, K. H., & Kumar, M. S. (2020). Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer's Disease. Current neuropharmacology. https://doi.org/10.2174/1570159x18666200528142429
Vancouver
Khan S, Barve KH, Kumar MS. Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer's Disease. Current neuropharmacology. 2020. doi:10.2174/1570159x18666200528142429. PMID: 32484110.
BibTeX
@article{khan2020-32484110,
author = {Khan, S. and Barve, K. H. and Kumar, M. S.},
title = {{Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer's Disease}},
journal = {Current neuropharmacology},
year = {2020},
doi = {10.2174/1570159x18666200528142429},
pmid = {32484110},
url = {https://doi.org/10.2174/1570159x18666200528142429}
}
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Key findings
- However, due to the non-feasibility of such methods, to diagnose and conclude the conditions, medical practitioners use tests that examine a patient's mental ability.
Why it matters
This review states that the cause of most Alzheimer's cases remains unknown and that patients generally receive a standard drug regimen regardless of cause, which may not halt or reverse disease progression. It discusses proposed approaches such as gene therapy and immunotherapy, but these are described as strategies to manage the disease, not established cures or preventions.
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Study details
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Current neuropharmacology) |
| Journal's citation record | 1 / 4 | Current Neuropharmacology: journal h-index 141 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 817 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 102.1 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 5 / 6 | Cited 30.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 13 other studies in this library |
| Still being cited | 4 / 4 | Cited 579 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Maushmi S. Kumar: h-index 18 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Narsee Monjee Institute of Management Studies: institution h-index 140 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32484110) |
| Free to read | 2 / 2 | Free to read |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.2174/1570159x18666200528142429
- PubMed: 32484110
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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