Newest studies

Arc mediates intercellular tau transmission via extracellular vesicles

49/100 ✓ Peer-reviewed Laboratory science Cell

Key finding: These results show that Arc is critical for the packaging of tau in EVs, which plays a significant role in intercellular tau transmission.

• Brain Biology

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Neuropathological perspectives on neuroinflammation and tau molecular imaging in frontotemporal lobar degeneration

34/100 ✓ Peer-reviewed Inflammation and the immune system Discover Neuroscience

Key finding: However, tau aggregation has been associated with neuroinflammation and oxidative stress. +3 more findings

• Brain Biology
• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Lecanemab use for early Alzheimer disease in Canada

37/100 ✓ Peer-reviewed Treatments Canadian Medical Association Journal

Key finding: Lecanemab is a humanized monoclonal antibody that binds soluble brain amyloid-β protein, promoting its removal and slowing the underlying process of Alzheimer disease. 1 This mechanism aligns with the amyloid hypothesis, a debated model of Alzheimer disease pathogenesis.1 Only patients with mild cog

• Treatments
• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Structured patient and public involvement programme development in low- and middle-income country health research: a scoping review of evidence gaps and a framework for future practice

32/100 ✓ Peer-reviewed Health systems and care delivery Research involvement and engagement

Key finding: This multisite initiative demonstrated that structured PPI is feasible in LMICs when supported by cultural adaptation, PPI coordinator roles, and tailored training for contributors and researchers.

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How Would Hospice Use Differ if Every Medicare Beneficiary Were in Medicare Advantage?

41/100 ✓ Peer-reviewed Health systems and care delivery Journal of Palliative Medicine

Key finding: Among 5153 decedents, 35.3% were in MA at death. +4 more findings

• End-of-Life Care

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Heterogeneous responses to risk-adjustment reform: evidence from dementia diagnosis in Medicare Advantage

32/100 ✓ Peer-reviewed Health systems and care delivery Health Affairs Scholar

Key finding: Incident dementia diagnoses increased in MA relative to traditional Medicare, despite an overall downward trend in diagnosis rates. +4 more findings

• Diagnosis
• Policy

Full summary, score breakdown and related studies → Original source

Digitized and AI-Assisted Scoring of Cognitive Assessments in ALS and Neurodegenerative Diseases: A Scoping Review of Consistency, Reliability, and Cross-Site Applicability

16/100 ⚠ Preprint — not yet peer-reviewed Cognitive tests and assessment PsyArXiv

Key finding: The Edinburgh Cognitive and Behavioral ALS Screen (ECAS) is the most validated and widely-used ALS-specific cognitive assessment tool, yet paper-and-pencil manual scoring introduces inter-rater variability that can significantly limit reliability and reproducibility in multi-site clinical trials. +1 more finding

• Diagnosis

Scored 47 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Individual-Level Traits Outweigh Neighborhood and Landscape Level Factors for Frugivorous Insect Parasites in Small Forest Patches

29/100 ✓ Peer-reviewed Risk factors Not indexed

Key finding: Our results suggest that in areas like upstate New York, where agricultural land uses are dominant, individual scale factors are the most influential. +2 more findings

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Hierarchical-circular model of biological memory: a multilevel hypothesis for pathogenesis and allostatic integrity in Alzheimer’s disease and related dementias

43/100 ✓ Peer-reviewed Prevention trials Frontiers in Dementia

Key finding: The Hierarchical-Circular Model of Biological Memory offers a unifying hypothesis for Alzheimer's disease and related dementias that bridges genetic, epigenetic, physiological, neuroimmune, and interoceptive processes across the lifespan. +1 more finding

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Lymphoid-like Suppressive Microglia in Alzheimer’s Disease: A New Neuroimmune Regulatory Axis?

32/100 ✓ Peer-reviewed Risk genes beyond APOE Cells

Key finding: Microglia are central regulators of Alzheimer's disease pathogenesis, but their roles cannot be reduced to a simple protective-versus-harmful dichotomy. +3 more findings

• Genetics
• Brain Biology
• Policy

Full summary, score breakdown and related studies → Original source

Cohort Profile: Kenya Life Panel Survey

54/100 ✓ Peer-reviewed Health systems and care delivery International Journal of Epidemiology

Key finding: Overall, 92.7% of the original cohort members participated in at least one follow-up round and 87.2% participated in at least two (balanced by deworming treatment status). +3 more findings

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The cost of dementia in the United States in 2026

49/100 ✓ Peer-reviewed Costs and economics Alzheimer's & Dementia

Key finding: The costs of dementia fall on families, highlighting limited policy and work supports. +1 more finding

• Policy
• Caregiving

Full summary, score breakdown and related studies → Original source

Pearls and Pitfalls of 18F-FDG PET/CT for Suspected Alzheimer's Disease in Patient with Down Syndrome

47/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Molecular imaging and radionuclide therapy

Key finding: Dementia in individuals with Down syndrome (DS) is the leading cause of early-onset cognitive decline occurring before the age of 50. +2 more findings

• Brain Scans
• Down Syndrome

Full summary, score breakdown and related studies → Original source

Polygenic Risk Scores for Incident Dementia in the Multi‐Ethnic Study of Atherosclerosis

44/100 ✓ Peer-reviewed Disparities Genetic Epidemiology

Key finding: We found comparable associations between dementia and PRS when comparing a C+T method with only 15 SNPs and PRS derived from Bayesian models that include > 800,000 SNPs (HR 5e‐08 = 1.18, 95% CI: 1.08–1.28; HR CSx = 1.17, 95% CI: 1.07−1.27). +2 more findings

• Health Equity
• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementias

81/100 ✓ Peer-reviewed Genetics Nature Genetics

Key finding: 128,681 cases/proxy cases and 849,833 controls analyzed, largest AD/ADRD GWAS meta-analysis to date at publication +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

MinderCare: protocol for a mixed-methods evaluation of a digitally enabled dementia care service

16/100 ⚠ Preprint — not yet peer-reviewed Health systems and care delivery medRxiv

Key finding: Strengths and limitations of this study This study evaluates a digitally enabled remote monitoring model for people living with dementia that integrates passive in-home sensors and algorithm-derived digital biomarkers to detect clinically relevant changes such as infection risk, behavioural disturbance and physiological deterioration. +4 more findings

• Care Services
• Digital Tools

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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MCH-Guard: Multimodal Machine Learning Framework for Risk Stratification of Cerebral Microhemorrhage Risk in the Alzheimer’s Disease Neuroimaging Initiative

16/100 ⚠ Preprint — not yet peer-reviewed Treatments medRxiv

Key finding: MCH-Guard offers a flexible clinical decision-support tool for optimizing spontaneous MCH & ARIA surveillance.

• Treatments

Scored 48 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Oral GLP-1 receptor agonist promotes astrocyte-neuron lactate and lipid transfer with neuroprotective effects

45/100 ✓ Peer-reviewed Drug development Cell metabolism

Key finding: OHP2 primarily activates GLP-1R on astrocytes, leading to increased aerobic glycolysis and driving lactate release. +4 more findings

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

Bridging the diagnostic gap: Expanding dementia care navigation for timely diagnosis

34/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Dementia care navigation (DCN) has demonstrated value in post-diagnosis settings.

• Diagnosis
• Health Equity

Full summary, score breakdown and related studies → Original source

Amantadine, Donepezil and Memantine Associated Arrhythmia in an Elderly Patient

16/100 ⚠ Preprint — not yet peer-reviewed Treatments Research Square

Key finding: 2.1 Case İnformation A 78 years old man was referred to the cardiology clinic because of mild dyspnea. +4 more findings

• Treatments

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

TACDAR: Tetra Alzheimer Disease Classification via Dilated Coordinate Attention Based RegNet

30/100 ✓ Peer-reviewed Brain scans and imaging International Journal of Computational Intelligence Systems

Key finding: Alzheimer disease (AD) destroys brain cells and the patient’s memory is lost as a result of a progressive and incurable neurodegenerative disease. +1 more finding

• Brain Scans
• Digital Tools

Full summary, score breakdown and related studies → Original source

Dysregulation of a novel autophagosome-mitochondria contact contributes to tauopathy-related neurodegeneration by disrupting autophagy

32/100 ✓ Peer-reviewed Disease mechanisms Autophagy

Key finding: Here, we reveal that tauopathy synapses exhibit excessive tethering of autophagosome/autophagic vacuole (AV)-mitochondria (Mito) contacts, driven by mitochondrial bioenergetic deficit-induced hyperactivity of adenosine monophosphate-activated protein kinase (AMPK) that results in accelerated turnover of the contact release factor TBC1D15. +1 more finding

• Brain Biology

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Frontotemporal dementia associated CHCHD10V57E mutation aggravates tau pathology via disrupting the CHCHD10-Rab7A-TBC1D15 complex

36/100 ✓ Peer-reviewed Disease mechanisms Cell Death and Disease

Key finding: Furthermore, we showed that phosphorylated tau accumulates within the endo-lysosomal system of the CHCHD10 V57E -expressing flies and mammalian cells. +2 more findings

• Brain Biology
• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Case Report: SIADH-Induced Hyponatremia Following Sertraline and Quetiapine Use in an Elderly Patient with Dementia: A Case Report

41/100 ✓ Peer-reviewed Risk factors F1000Res

Key finding: This case underscores the importance of routine sodium monitoring in elderly patients with dementia initiated on serotonergic or antipsychotic therapy. +1 more finding

• Risk Factors
• Treatments

Full summary, score breakdown and related studies → Original source

Cerebrospinal fluid NPTX2/p-tau ratio as a biomarker for cognitive decline in neurodegenerative diseases

66/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: The NPTX2/p-tau ratio enhanced diagnostic performance of standalone NPTX2 and p-tau, particularly for DLB and FTLDrs (area under the curve [AUC]NPTX2/p-tau = 0.78-0.79 vs. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source