Newest studies

Trends and forecasts of the prevalence and mortality of Alzheimer’s disease and other dementias in China

43/100 ✓ Peer-reviewed How common it is Frontiers in Public Health

Key finding: In 2021, the age-standardized prevalence of AD and other dementia in China was 1,194 per 100,000 (95% CI: 1018-1,383), and the mortality rate was 35 per 100,000 (95% CI: 9-93). +4 more findings

Full summary, score breakdown and related studies → Original source

Contrasting Adult and Pediatric Populations in a Cohort of At-Risk Relatives in The T1D TrialNet Pathway to Prevention Study

60/100 ✓ Peer-reviewed Prevention and risk Diabetes Care

Key finding: Adults were more likely than children to screen positive for a single autoantibody (4.0% vs. 2.6%) but less likely for multiple autoantibodies (0.83% vs. 2.8%; P < 0.001). +4 more findings

• Prevention

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High-fat diet may increase the risk of insulin resistance by inducing dysbiosis

40/100 ✓ Peer-reviewed Prevention and risk Metabolism Open

Key finding: These findings may clarify valuable preventive and therapeutic targets for countermeasures to IR in people who use the Western diet.

• Lifestyle

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Cross-sectional associations of plasma vitamin D with plasma phosphorylated tau-181 and plasma neurofilament light chain in older adults with memory complaints

45/100 ✓ Peer-reviewed Biomarkers Neurobiology of Disease

Key finding: Lack of vitamin D is associated with cognitive decline and Alzheimer's disease. +4 more findings

• Biomarkers
• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Glucagon-Like Peptide-1 Receptor Agonists and Incidence of Dementia Among Older Adults With Type 2 Diabetes: A Target Trial Emulation

65/100 ✓ Peer-reviewed Prevention and risk Annals of Internal Medicine

Key finding: Among older adults with diabetes, no clear evidence was found that the incidence of dementia differed overall between patients using GLP-1RAs versus DPP4is. +3 more findings

• Risk Factors
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Cell-type-directed network-correcting combination therapy for Alzheimer's disease

43/100 ✓ Peer-reviewed Genetics Cell

Key finding: Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by heterogeneous molecular changes across diverse cell types, posing significant challenges for treatment development. +2 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Curcumin and Dementia: A Systematic Review of Its Effects on Oxidative Stress and Cognitive Outcomes in Animal Models

58/100 ✓ Peer-reviewed Disease mechanisms International journal of molecular sciences

Key finding: All studies assessing malondialdehyde (MDA) reported significant reductions, indicating reduced oxidative stress. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

A normative calculator for MoCA domain scores: proxy for Z-scores of conventional neuropsychological tests

48/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer s Research & Therapy

Key finding: MDS varied significantly by age, sex, education, and language of administration even among participants with normal cognition. +4 more findings

• Diagnosis

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Finger tapping and paratonia assessment in older adults with and without Mild cognitive impairment, motor-cognitive correlations

47/100 ✓ Peer-reviewed Mild cognitive impairment Applied Neuropsychology Adult

Key finding: Cognitively Impaired participants exhibited a prolonged strike duration compared to healthy participants. +2 more findings

• Early Stage
• Diagnosis

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The global, regional, and national burden and attributable risk factors of Alzheimer's disease and other dementias, 1990-2021: A systematic analysis for the Global Burden of Disease Study

43/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer s Disease

Key finding: Smoking was identified as the primary risk factor for dementia burden among males, whereas obesity was the leading risk factor for females. +2 more findings

• Risk Factors

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A Comparative Study of Burden of Care, Anxiety, and Well-Being Among Family Caregivers of Elderly with Dementia: Evidence from Kuwait

45/100 ✓ Peer-reviewed Caregiving Healthcare

Key finding: This study included 180 (65%) caregivers for the elderly with dementia and 98 (35%) without dementia. +4 more findings

• Caregiving

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The utility of the Ascertain Dementia Eight-item Questionnaire (AD8) and Mini-Cog in detecting cognitive impairment in older surgical patients – The Detect CI study

49/100 ✓ Peer-reviewed Getting a diagnosis Journal of Clinical Anesthesia

Key finding: Of 394 participants, 35 % had preoperative CI on the MoCA, 15 % on the AD8, and 12 % on the Mini-Cog. +4 more findings

• Diagnosis

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Lifestyle Medicine for Obesity in the Era of Highly Effective Anti-Obesity Treatment

48/100 ✓ Peer-reviewed Prevention and risk Nutrients

Key finding: Clinicians treating obesity should be aware of their own biases, make efforts to reduce stigmatizing experiences in their practice, and address weight stigma in their treatment plans as needed. +4 more findings

• Lifestyle
• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source

Reduced retinal thickness and risk of Alzheimer’s disease: a bidirectional two-sample Mendelian randomization study

44/100 ✓ Peer-reviewed Genetics Ageing and Neurodegenerative Diseases

Key finding: No significant associations were found between retinal thickness and AD risk (RNFL: odds ratio [OR]IVW = 1.001, 95% confidence interval [CI] = 0.986-1.017, P = 0.883; GCIPL: ORIVW = 1.008, 95% CI = 0.997-1.019, P = 0.172). +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Combating Genetic Heterogeneity for Polygenic Prediction of Susceptibility to Brain β-Amyloid Deposition

33/100 ✓ Peer-reviewed Genetics Neurology Genetics

Key finding: The APOE (apolipoprotein E) ε4 allele is the strongest known genetic risk factor for sporadic Alzheimer disease (AD) and for brain amyloidosis, an early marker of disease pathophysiology. +3 more findings

• Genetics

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Genetic Correlates of Presenile Dementia and Cognitive Decline in the Armenian Population Following COVID-19: A Case-Control Study

42/100 ✓ Peer-reviewed Getting a diagnosis International Journal of Molecular Sciences

Key finding: Lower cognitive performance was associated with CNVs in PSEN1 (exons 1, 9, 12), GRN (exons 1, 6, 12), and MAPT (exons 2, 8), along with viral infections (HSV-1, HSV-2, HAV-2). +1 more finding

• Diagnosis
• Genetics

Full summary, score breakdown and related studies → Original source

Patterns and predictors of cholinesterase inhibitor use in dementia with Lewy bodies

52/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia (New York, N. Y.)

Key finding: We found that 51.9% of DLB patients were ever prescribed a ChEI, and those who were prescribed a ChEI had a greater diagnosis interval. +4 more findings

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

High-fidelity and differential nonsense suppression in live cells and a frontotemporal dementia allele with human transfer RNAs

42/100 ✓ Peer-reviewed Lewy body dementia Nucleic Acids Research

Key finding: With tRNA sequencing, we showed that a suppressor tRNA derived from the TCG-3-1 gene was expressed 2.1-fold higher and generated 1.8-fold more nonsense suppression than a tRNA derived from the TCG-4-1 gene. +1 more finding

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Impaired BDNF-TrkB trafficking and signalling in Down syndrome basal forebrain neurons

40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Cell death & disease

Key finding: Individuals with Down syndrome (DS) are at an increased risk of developing AD compared to the general population. +4 more findings

• Down Syndrome
• Brain Biology

Full summary, score breakdown and related studies → Original source

Nutrition in palliative care at the end of life: Bibliometric and network analysis until 2024

33/100 ✓ Peer-reviewed End-of-life care Medicine

Key finding: Three hundred fourteen articles from 48 countries were included. +4 more findings

• End-of-Life Care
• Lifestyle

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An inflammatory fingerprint in mild cognitively impaired patients is reversed by physical and cognitive training

43/100 ✓ Peer-reviewed Prevention trials Brain Behavior & Immunity - Health

Key finding: At baseline, MCI participants displayed elevated levels of IL-17A, CX3CL1, CCL11, with a borderline increase of IL-6 and TNFα. +4 more findings

• Brain Biology

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Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease

77/100 ✓ Peer-reviewed TREM2 and immune genetics Genome biology

Key finding: Using cross-population GWAS meta-analyses, we identify novel LOAD susceptibility loci in/near LRRC4C and LHX5-AS1, both with known roles in neuronal development, as well as several novel population-unique loci.

• Genetics

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Community Socioeconomic Disadvantage relates to White Matter Hyperintensity Burden in Mid-to-Late Life Adults

45/100 ✓ Peer-reviewed Risk factors Biopsychosocial science and medicine

Key finding: Linear regression models showed that higher community deprivation on the ADI associated with greater WMH volume, independently of age, sex, years of education and smoking.

• Risk Factors
• Brain Scans
• Health Equity

Full summary, score breakdown and related studies → Original source

Novel Dual Mechanism GRT-X Agonist Acting on Kv7 Potassium Channel/Translocator Protein Receptor Prevents Motoneuron Degeneration Following Exposure to Mouse and Human Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Astrocyte-Conditioned Media

36/100 ✓ Peer-reviewed Inflammation and the immune system ACS Chemical Neuroscience

Key finding: We exposed primary rat ventral spinal cord neuronal cultures and rat spinal cord organotypic cultures to astrocyte-conditioned medium derived from primary mouse ALS astrocytes expressing mutant human SOD1 (SOD1 G93A -ACM) or from human-induced pluripotent stem cell (iPSC)-derived astrocytes carrying an ALS-causing mutation in SOD1 (SOD1 D90A -ACM) or an ALS/FTD-causing mutation in TDP-43 (TDP43 A90 V -ACM). +4 more findings

• Brain Biology
• Other Dementias
• Prevention

Full summary, score breakdown and related studies → Original source

Parenchymal and Dyshoric Fibrillar Amyloid Pathology in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2

35/100 ✓ Peer-reviewed Brain tissue and pathology American Journal Of Pathology

Key finding: Cerebral proteomic analyses revealed that while rTg-D HEM rats and rTg-D HOM rats shared some common differentially expressed proteins compared with wild-type rats, rTg-D HOM rats exhibited many more elevated proteins. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source