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57/100

✓ Peer-reviewed alzhub usefulness score 57 out of 100. Brain tissue and pathology

Topic: Disease mechanisms in lab and animal studies

Plain-language summary

Compared to CTR, both AD-αSAA- and AD-αSAA+ showed widespread cortical thinning. Direct comparison of AD-αSAA+ versus AD-αSAA- revealed differential involvement of insular, entorhinal, lateral temporal, pre and postcentral gyrus, frontal cortices, and amygdala, although with minimum size effect. α-Syn copathology was associated with more extensive and pronounced atrophy, especially in frontal, lateral temporal, entorhinal, and amygdalar regions. This suggests that α-syn is associated with greater neurodegeneration beyond typical AD patterns.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Esteller-Gauxax, D., Guillén, N., Falgàs, N., Bosch, B., Tort-Merino, A., Borrego-Écija, S., et al. (2026). Atrophy signature for alpha-synuclein copathology in Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). https://doi.org/10.1002/dad2.70347

Vancouver

Esteller-Gauxax D, Guillén N, Falgàs N, Bosch B, Tort-Merino A, Borrego-Écija S, et al. Atrophy signature for alpha-synuclein copathology in Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). 2026. doi:10.1002/dad2.70347. PMID: 42255968.

BibTeX

@article{estellergauxax2026-42255968,
  author  = {Esteller-Gauxax, Diana and Guillén, Núria and Falgàs, Neus and Bosch, Beatriz and Tort-Merino, Adrià and Borrego-Écija, Sergi and Puey, Roger and Ruiz-Garcia, Raquel and others},
  title   = {{Atrophy signature for alpha-synuclein copathology in Alzheimer's disease}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2026},
  doi     = {10.1002/dad2.70347},
  pmid    = {42255968},
  url     = {https://doi.org/10.1002/dad2.70347}
}

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How to read this study

Design: our record does not state a study design, so check the methods section of the original before weighing the result.
Size: the record lists 139 participants. Ask whether that is enough for the question, and who they were.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded low. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Low means the abstract matched neither pattern. It is the default label, and it does not mean the work is poor; many sound lab and imaging papers land here. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

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Key findings

Compared to CTR, both AD-αSAA- and AD-αSAA+ showed widespread cortical thinning.
Direct comparison of AD-αSAA+ versus AD-αSAA- revealed differential involvement of insular, entorhinal, lateral temporal, pre and postcentral gyrus, frontal cortices, and amygdala, although with minimum size effect. α-Syn copathology was associated with more extensive and pronounced atrophy, especially in frontal, lateral temporal, entorhinal, and amygdalar regions.
This suggests that α-syn is associated with greater neurodegeneration beyond typical AD patterns.

Study details

Participants139
Evidence strengthLow

How this study scored 57/100

Published in a leading specialty journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 32 of the 56 points we could judge it on, which is 57 out of 100.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (Alzheimer's & dementia (Amsterdam, Netherlands))
Journal's citation record	— / 4	No journal record from OpenAlex — left out of this score
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	2 / 4	139 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	— / 7	No citation count (not found in OpenAlex) — left out of this score
Citations per year	— / 5	No citation count or no year — left out of this score
Impact for its field and year	— / 6	No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here	— / 6	Not yet checked against this library's citation graph — left out of this score
Still being cited	— / 4	No yearly citation counts — left out of this score
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	— / 3	No institution listed in OpenAlex — left out of this score
Multicenter collaboration	— / 3	Institutions not listed — left out of this score
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 42255968)
Free to read	— / 2	Access not recorded — left out of this score
Points	32 / 56	Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 32 of the 56 points we could judge it on is 57 out of 100.
Total	57 / 100	—

What each of these 20 components measures, and what this score is not →

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