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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 12,001–12,025 of 27,380 studies, newest first · page 481 of 1096.

January 2020 25

  1. 2020-01-14

    Chronic PD-1 Checkpoint Blockade Does Not Affect Cognition or Promote Tau Clearance in a Tauopathy Mouse Model

    ✓ Peer-reviewed Drug development Frontiers in aging neuroscience

    Key finding: These findings indicate that further research is needed before clinical trials based on PD-1 checkpoint immune blockage are devised for tauopathies.

    Full summary, score breakdown and related studies → Original source

  2. 2020-01-14

    Apolipoprotein E Interferes with IAPP Aggregation and Protects Pericytes from IAPP-Induced Toxicity

    ✓ Peer-reviewed Genetics Biomolecules

    Key finding: Taken together, our results suggest that ApoE has a generic amyloid-interfering property and can be protective against amyloid-induced cytotoxicity, but there is a loss of function for the ApoE4 variant.

    Full summary, score breakdown and related studies → Original source

  3. 2020-01-14

    Hippocampal plasticity underpins long-term cognitive gains from resistance exercise in MCI

    ✓ Peer-reviewed Prevention trials NeuroImage. Clinical

    Key finding: Furthermore, hippocampal subfields susceptible to atrophy in AD were protected by PRT revealing an elimination of long-term atrophy in the left subiculum, and attenuation of atrophy in left CA1 and dentate gyrus when compared to SHAM+SHAM (p = 0.023, p = 0.020 and p = 0.027). +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2020-01-14

    Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia

    ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology, neurosurgery, and psychiatry

    Key finding: There are few validated fluid biomarkers in frontotemporal dementia (FTD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2020-01-14

    Glycan biomarkers for Alzheimer disease correlate with T-tau and P-tau in cerebrospinal fluid in subjective cognitive impairment

    ✓ Peer-reviewed Tau biomarkers The FEBS journal

    Key finding: A wealth of clinical studies support that the disease starts to develop decades before the first symptoms appear, emphasizing the importance of studying early changes for improving early diagnosis and guiding toward novel treatment strategies. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2020-01-13

    Single-nucleus RNA sequencing reveals transcriptional changes of hippocampal neurons in APP23 mouse model of Alzheimer's disease

    ✓ Peer-reviewed Genetics Bioscience, biotechnology, and biochemistry

    Key finding: Our findings revealed multiple neuronal subtype-specific transcriptional changes that may lead to targets for future studies of AD.

    Full summary, score breakdown and related studies → Original source

  7. 2020-01-13

    Palliative care for non-cancer conditions in primary care: a time trend analysis in the UK (2009-2014)

    ✓ Peer-reviewed End-of-life care BMJ supportive & palliative care

    Key finding: Recording of a palliative care approach for non-cancer conditions has increased since the introduction of the UK End-of-Life Care Strategy, but remains inadequate. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2020-01-13

    Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease

    ✓ Peer-reviewed TREM2 and immune genetics Nature medicine

    Key finding: Variants of the microglia receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD risk, and activation of disease-associated microglia (DAM) is dependent on TREM2 in mouse models of AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2020-01-08

    Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression

    ✓ Peer-reviewed Tau biomarkers Neuron

    Key finding: Comparisons of brain tissue and cerebrospinal fluid proteomes reveal biomarker candidates. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2020-01-08

    Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease

    ✓ Peer-reviewed Tau biomarkers Nature

    Key finding: In a second cohort, we found that CD8 + T EMRA cells were negatively associated with cognition. +2 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2020-01-08

    Long-term exposure to ambient air pollution, APOE-ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan

    ✓ Peer-reviewed Disparities Environment international

    Key finding: These results add to the body of evidence on the adverse impact of ambient air pollution on cognitive aging and brain health and provide new insights into the genetic and behavioral factors that may impact individual susceptibility. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2020-01-08

    Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: In response to sleep loss (+17.2%), compared with normal sleep (+1.8%), the evening to morning ratio was increased for t-tau ( p = 0.035). +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2020-01-07

    Autosomal Dominantly Inherited Alzheimer Disease: Analysis of genetic subgroups by Machine Learning

    ✓ Peer-reviewed Risk genes beyond APOE An international journal on information fusion

    Key finding: Despite subjects with Dominantly-Inherited Alzheimer's Disease (DIAD) represent less than 1% of all Alzheimer's Disease (AD) cases, the Dominantly Inherited Alzheimer Network (DIAN) initiative constitutes a strong impact in the understanding of AD disease course with special emphasis on the presyptomatic disease phase.

    Full summary, score breakdown and related studies → Original source

  14. 2020-01-07

    Microglia, Lifestyle Stress, and Neurodegeneration

    ✓ Peer-reviewed Prevention trials Immunity

    Key finding: In parallel, genetic association studies have identified several gene risk factors associated with Alzheimer's disease that are specifically or highly expressed by microglia in the central nervous system (CNS).

    Full summary, score breakdown and related studies → Original source

  15. 2020-01-07

    Evidence for Environmental Noise Effects on Health for the United Kingdom Policy Context: A Systematic Review of the Effects of Environmental Noise on Mental Health, Wellbeing, Quality of Life, Cancer, Dementia, Birth, Reproductive Outcomes, and Cognition

    ✓ Peer-reviewed Disparities International journal of environmental research and public health

    Key finding: Using the GRADE methodology (Grading of Recommendations Assessment, Development and Evaluation) most evidence was rated as low quality as opposed to very low quality in the previous reviews. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2020-01-07

    Association between insomnia and cognitive performance, gray matter volume, and white matter microstructure in cognitively unimpaired adults

    ✓ Peer-reviewed Genetics Alzheimer's research & therapy

    Key finding: Insomnia in cognitively unimpaired adults at increased risk for AD is associated to poorer performance in some executive functions and volume changes in cortical and subcortical gray matter, including key areas involved in Alzheimer's disease, as well as decreased white matter diffusivity. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2020-01-06

    CircNF1-419 improves the gut microbiome structure and function in AD-like mice

    ⚠ Retracted — do not rely on it Disease mechanisms Aging

    Key finding: Our pre-experiments found that the brain circRNA sequence profiles and gut microbiota in AD-like mice were changed, as circNF1-419 could enhance autophagy to ameliorate senile dementia in AD-like mice, so we conclude that there might some connections between circRNA and gut microbiome. +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2020-01-06

    Caregiver-Reported Barriers to Quality End-of-Life Care in Dementia With Lewy Bodies: A Qualitative Analysis

    ✓ Peer-reviewed End-of-life care The American journal of hospice & palliative care

    Key finding: Many identified themes were consistent with published barriers to quality EOL care in dementia.

    Full summary, score breakdown and related studies → Original source

  19. 2020-01-06

    Clinical trials of new drugs for Alzheimer disease

    ✓ Peer-reviewed Inflammation and the immune system Journal of biomedical science

    Key finding: Given the seriousness of the disease and continual increase in patient numbers, developing effective therapies to treat AD has become urgent. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2020-01-06

    Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium

    ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: The CDR® plus NACC FTLD was able to detect early symptoms in the mildly impaired participants who were rated as CDR® sum of boxes (CDR®-SB) = 0. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2020-01-06

    New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures

    ✓ Peer-reviewed Digital health tools Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: New personalized endpoints that are clinically meaningful to individuals and their families should be developed.

    Full summary, score breakdown and related studies → Original source

  22. 2020-01-05

    STARD1 and NPC1 expression as pathological markers associated with astrogliosis in post-mortem brains from patients with Alzheimer's disease and Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Aging

    Key finding: Hippocampal areas stained with the recombinant GST-PFO probe showed increased mitochondrial cholesterol within astrocytes of brains from patients with AD and DS-brains compared to controls. +1 more finding

    Full summary, score breakdown and related studies → Original source

  23. 2020-01-04

    Clinical significance of focal ß-amyloid deposition measured by 18F-flutemetamol PET

    ✓ Peer-reviewed Brain scans and imaging Alzheimer's research & therapy

    Key finding: 53/310 (17.1%) subjects were classified as Focal-FMM. +4 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2020-01-04

    Tau-positron emission tomography correlates with neuropathology findings

    ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Elevated FTP-PET reflects Braak IV or greater neuropathology. +2 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2020-01-04

    Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease

    ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Our data suggest that structural MRI can be used to identify biologically and clinically meaningful subtypes of AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →