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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 11,876–11,900 of 27,380 studies, newest first · page 476 of 1096.

February 2020 25

  1. 2020-02-27

    Sleep Deprivation Affects Tau Phosphorylation in Human Cerebrospinal Fluid

    ✓ Peer-reviewed Disease mechanisms Annals of neurology

    Key finding: Tau hyperphosphorylation is an early step in tau-mediated neurodegeneration and is associated with intracellular aggregation of tau as neurofibrillary tangles, neuronal and synaptic loss, and eventual cognitive dysfunction in Alzheimer disease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2020-02-27

    Novel monoclonal antibody 3B8 specifically recognizes pyroglutamate-modified amyloid β 3-42 peptide in brain of AD patients and 3xTg-AD transgenic mice

    ✓ Peer-reviewed Down syndrome and Alzheimer's Neuroscience letters

    Key finding: AβN3(pE), an Aβ peptide bearing an amino-terminal pyroglutamate at position 3, is a significant constituent of intracellular, extracellular and vascular Aβ deposits in brain tissue from individuals with AD and Down syndrome. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2020-02-26

    Targeted Mass Spectrometry Suggests Beta-Synuclein as Synaptic Blood Marker in Alzheimer's Disease

    ✓ Peer-reviewed Biomarkers Journal of proteome research

    Key finding: Using quantitative mass spectrometry (IP-MS, MRM) we observed increased concentrations of the presynaptic protein beta-synuclein (βSyn) in CSF and blood of AD patients (n = 64, p < 0.01) and confirmed this finding in two validation cohorts (AD: n = 40 and n = 49, controls: n = 44 and n = 25). βSyn was already increased in patients with mild cognitive impairment (p < 0.01) and was also markedly increased in Creutzfeldt-Jakob disease (CJD; n = 25, p < 0.001) but not behavioral variant frontotemporal dementia (n = 16), dementia with Lewy bodies/Parkinson's disease dementia (n = 13), Parkinson's disease (n = 25), or amyotrophic lateral sclerosis (n = 30). +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2020-02-26

    Cognitive training interventions for dementia and mild cognitive impairment in Parkinson's disease

    ✓ Peer-reviewed Disparities The Cochrane database of systematic reviews

    Key finding: Selection criteria We included randomised controlled trials where the participants had PDD or PD-MCI, and where the intervention was intended to train general or specific areas of cognitive function, targeting either a single domain or multiple domains of cognition, and was compared to a control condition. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2020-02-25

    Receipt of Eye Care Services among Medicare Beneficiaries with and without Dementia

    ✓ Peer-reviewed Brain scans and imaging Ophthalmology

    Key finding: A total of 4 451 200 beneficiaries met inclusion criteria; 3 805 718 (85.5%) received eye care during the study period, and 391 556 (8.8%) had diagnosed dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2020-02-24

    GenEpi: gene-based epistasis discovery using machine learning

    ✓ Peer-reviewed Genetics BMC bioinformatics

    Key finding: In this regard, this study presents GenEpi, a computational package to uncover epistasis associated with phenotypes by the proposed machine learning approach. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2020-02-24

    The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Journal of neuroinflammation

    Key finding: Our findings highlight sexual dimorphism in the behavior, neuropathology, and plasma proteins in tau P301S transgenic AD mice, indicating that the use of male P301S transgenic mice may be more suitable for assessing anti-phosphorylated tau therapeutic strategies for AD and related tauopathies, and the MIP-3α may be a new potential plasma biomarker. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2020-02-24

    Perivascular spaces in the brain: anatomy, physiology and pathology

    ✓ Peer-reviewed Brain scans and imaging Nature reviews. Neurology

    Key finding: Perivascular spaces include a variety of passageways around arterioles, capillaries and venules in the brain, along which a range of substances can move. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2020-02-23

    Neuroticism, conscientiousness, and in vivo Alzheimer pathologies measured by amyloid PET and MRI

    ✓ Peer-reviewed Biomarkers Psychiatry and clinical neurosciences

    Key finding: The present findings suggest that amyloid-independent regional neurodegeneration might underlie relations of neuroticism and conscientiousness with AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2020-02-21

    Brain injury-induced dysfunction of the blood brain barrier as a risk for dementia

    ✓ Peer-reviewed Disease mechanisms Experimental neurology

    Key finding: BBB permeability changes after TBI result in leakage of serum proteins, influx of immune cells, perivascular inflammation, as well as impairment of efflux transporter systems and accumulation of aggregation-prone molecules involved in hallmark pathologies of neurodegenerative diseases with dementia.

    Full summary, score breakdown and related studies → Original source

  11. 2020-02-20

    Brain iron deposition is linked with cognitive severity in Parkinson's disease

    ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology, neurosurgery, and psychiatry

    Key finding: Dementia is common in Parkinson's disease (PD) but measures that track cognitive change in PD are lacking. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2020-02-19

    [Assisted living facilities in inpatient and outpatient settings]

    ✓ Peer-reviewed Health systems and care delivery Zeitschrift fur Gerontologie und Geriatrie

    Key finding: Despite a formal inpatient or outpatient classification, the residents living in AL facilities showed significantly higher values for well-being and showed significantly less agitated, challenging behavior compared to the nursing home. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2020-02-19

    Systematic validation of variants of unknown significance in APP, PSEN1 and PSEN2

    ✓ Peer-reviewed Risk genes beyond APOE Neurobiology of disease

    Key finding: In this study, we analyzed Aβ isoform levels by ELISA in a cell-based system in which each reported pathogenic and risk variant in APP, PSEN1, and PSEN2 was expressed individually. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2020-02-19

    Race modifies default mode connectivity in Alzheimer's disease

    ✓ Peer-reviewed Tau biomarkers Translational neurodegeneration

    Key finding: We found that race modifies the relationship between functional connectivity of default mode network subsystems and cognitive performance, tau, and amyloid levels. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2020-02-19

    The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

    ✓ Peer-reviewed Lewy body dementia Proceedings of the National Academy of Sciences of the United States of America

    Key finding: Using an integrative omics, biochemical and imaging approach, we dissected the molecular events associated with the different stages of LB formation and their contribution to neuronal dysfunction and degeneration.

    Full summary, score breakdown and related studies → Original source

  16. 2020-02-17

    Deintensification of Diabetes Medications among Veterans at the End of Life in VA Nursing Homes

    ✓ Peer-reviewed Digital health tools Journal of the American Geriatrics Society

    Key finding: Deintensification of treatment regimens occurred in less than one-half of potentially overtreated Veterans and was more strongly associated with low HbA1c values and use of medications with high risk for hypoglycemia, rather than other resident characteristics. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2020-02-15

    Validation of two short versions of the Zarit Burden Interview in the palliative care setting: a questionnaire to assess the burden of informal caregivers

    ✓ Peer-reviewed End-of-life care Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    Key finding: The ZBI-7 is a valid instrument for measuring caregiver burden in PC. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2020-02-14

    Audiometric Age-Related Hearing Loss and Cognition in the Hispanic Community Health Study

    ✓ Peer-reviewed Risk factors The journals of gerontology. Series A, Biological sciences and medical sciences

    Key finding: A 20-dB (equivalent to a one-category worsening) increase in HL was associated with a -1.53 (95% CI, -2.11, -0.94) raw score point difference in the DSST, adjusting for demographics, hearing aid use, and cardiovascular disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2020-02-14

    Hearing Impairment and Cognitive Decline in Older, Community-Dwelling Adults

    ✓ Peer-reviewed Risk factors The journals of gerontology. Series A, Biological sciences and medical sciences

    Key finding: Of 1,164 participants (mean age 73.5 years, 64% women), 580 (49.8%) had mild hearing impairment and 196 (16.8%) had moderate/severe hearing impairment. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2020-02-14

    Central and Peripheral Mechanisms in ApoE4-Driven Diabetic Pathology

    ✓ Peer-reviewed Genetics International journal of molecular sciences

    Key finding: In the present study, we employed a model of APOE-targeted replacement mice and high-fat diet (HFD)-induced insulin resistance to investigate diabetic mechanisms associated with apoE4 pathology and the extent to which they are driven by peripheral and central processes. +4 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2020-02-13

    Amyloid duration is associated with preclinical cognitive decline and tau PET

    ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia (Amsterdam, Netherlands)

    Key finding: Amyloid chronicity provides unique information about cognitive decline and neurofibrillary tangle development and may be useful to investigate preclinical Alzheimer's disease. +1 more finding

    Full summary, score breakdown and related studies → Original source

  22. 2020-02-13

    The β-Secretase BACE1 in Alzheimer's Disease

    ✓ Peer-reviewed Risk genes beyond APOE Biological psychiatry

    Key finding: A safe and efficacious compound with high substrate selectivity as well as a more accurate dose regimen, patient population, and disease stage may yet be found. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2020-02-12

    Novel tau filament fold in corticobasal degeneration

    ✓ Peer-reviewed Genetics Nature

    Key finding: Here we use cryo-electron microscopy to analyse the structures of tau filaments extracted from the brains of three individuals with CBD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2020-02-12

    Triggered Palliative Care Consults: A Systematic Review of Interventions for Hospitalized and Emergency Department Patients

    ✓ Peer-reviewed End-of-life care Journal of pain and symptom management

    Key finding: We present a range of trigger tools spanning different hospital settings and patient populations.

    Full summary, score breakdown and related studies → Original source

  25. 2020-02-12

    Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles

    ✓ Peer-reviewed Lewy body dementia Autophagy

    Key finding: Organelle-specific autophagy is one of the major subtypes of autophagy, selectively targeting different organelles for quality control. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →