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Piperine: A comprehensive review of methods of isolation, purification, and biological properties
Anshuly Tiwari, Kakasaheb Ramoo Mahadik, Satish Y. Gabhe. Medicine in Drug Discovery, 2020-04-01
Topic: Gut, metabolism and diet
Black pepper is an autoicous and decorous vine cultivated and harvested in tropical regions of Sri Lanka and India. Black pepper is one of the most commonly consumed spices, and its pungency is due to the presence of an alkaloid known as piperine, volatile chemical constituents, and essential oils. Piperine is found in black pepper (piper nigrum), white pepper, and long pepper (piper longum) belonging to the family Piperaceae. Piperine represents diverse biological activities, such as anti-inflammatory, anticancer, antiviral, anti-larvicidal, pesticide, anti-Alzheimer’s, antidepressant, and most importantly piperine is known as the bioavailability enhancer. The current review article aims to explore the extraction of piperine from different species of pepper, its total synthesis, pharmacokinetic study and various biological activities of piperine. Furthermore, different combinations of piperine with available marketed drugs to improve the bioavailability have also been included. Different studies on piperine suggest that piperine acts as an excellent bioenhancer to improve the bioavailability of drugs with poor ADMET properties. Some studies also indicate that piperine shows synergistic effects when taken in combination with various classes of drugs.
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APA 7th
Tiwari, A., Mahadik, K. R., & Gabhe, S. Y. (2020). Piperine: A comprehensive review of methods of isolation, purification, and biological properties. Medicine in Drug Discovery. https://doi.org/10.1016/j.medidd.2020.100027
Vancouver
Tiwari A, Mahadik KR, Gabhe SY. Piperine: A comprehensive review of methods of isolation, purification, and biological properties. Medicine in Drug Discovery. 2020. doi:10.1016/j.medidd.2020.100027.
BibTeX
@article{tiwari2020-b479f05b,
author = {Tiwari, Anshuly and Mahadik, Kakasaheb Ramoo and Gabhe, Satish Y.},
title = {{Piperine: A comprehensive review of methods of isolation, purification, and biological properties}},
journal = {Medicine in Drug Discovery},
year = {2020},
doi = {10.1016/j.medidd.2020.100027},
url = {https://doi.org/10.1016/j.medidd.2020.100027}
}
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Key findings
- Different studies on piperine suggest that piperine acts as an excellent bioenhancer to improve the bioavailability of drugs with poor ADMET properties.
- Some studies also indicate that piperine shows synergistic effects when taken in combination with various classes of drugs.
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Study details
- Evidence strengthLow
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 23 of the 58 points we could judge it on, which is 40 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Medicine in Drug Discovery) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Points | 23 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 23 of the 58 points we could judge it on is 40 out of 100. |
| Total | 40 / 100 | — |
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