Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 12,376–12,400 of 27,380 studies, newest first · page 496 of 1096.
October 2019 25
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2019-10-25
Machine Learning-Based Framework for Differential Diagnosis Between Vascular Dementia and Alzheimer's Disease Using Structural MRI Features
46/100 ✓ Peer-reviewed Digital health tools Frontiers in neurology
Key finding: The experimental results demonstrate that the SVM with RBF achieved an encouraging performance with sensitivity (SEN), specificity (SPE), and accuracy (ACC) values of 82.65%, 87.17%, and 84.35%, respectively (AUC = 0.861, 95% CI = 0.820-0.902), for the differential diagnosis between VaD and AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-10-25
Tau deposition is associated with functional isolation of the hippocampus in aging
53/100 ✓ Peer-reviewed Brain scans and imaging Nature communications
Key finding: Functional disconnection between the hippocampus and other components of the MTL memory system, particularly an anterior-temporal network specialized for object memory, is also associated with higher hippocampal ReHo and greater tau burden in anterior-temporal regions. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-10-24
Microbiota-gut-brain axis and toll-like receptors in Alzheimer's disease
39/100 ✓ Peer-reviewed Disease mechanisms Computational and structural biotechnology journal
Key finding: Dysbiosis of gut microbiota can induce increased intestinal permeability and systemic inflammation, which may lead to the development of AD pathologies and cognitive impairment via the neural, immune, endocrine, and metabolic pathways. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-24
How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases
41/100 ✓ Peer-reviewed Prevention trials Diabetes, metabolic syndrome and obesity : targets and therapy
Key finding: This paper shows that the transition from Paleolithic nutrition to Western diets, along with lack of corresponding genetic adaptations, cause significant distortions of the fine-tuned metabolism that has evolved over millions of years of human evolution in adaptation to Paleolithic diets. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-10-24
Elements of Palliative Care in the Last 6 Months of Life: Frequency, Predictors, and Timing
41/100 ✓ Peer-reviewed End-of-life care Journal of general internal medicine
Key finding: Although a high proportion of patients received elements of palliative care, transitions to a goal of comfort or hospice happened very near death. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-24
Effects of computerised cognitive training on cognitive impairment: a meta-analysis
67/100 ✓ Peer-reviewed Prevention trials Journal of neurology
Key finding: CCT was most effective in cognitive rehabilitation, particularly in the subdomain of memory. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-10-23
Palliative Care in a Community-Based Serious-Illness Care Program
48/100 ✓ Peer-reviewed End-of-life care Journal of palliative medicine
Key finding: Patients were seen in an 18-month time frame (n = 159). +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-23
Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease
38/100 ✓ Peer-reviewed Biomarkers International review of neurobiology
Key finding: Multiplex immunoassay conducted on brain lysates showed that alcohol drinking upregulated primary markers of AD pathology in 3xTg-AD mice: Aβ 42/40 ratio in the lateral entorhinal and prefrontal cortex and total Tau expression in the lateral entorhinal cortex, medial prefrontal cortex, and amygdala at 1-month post alcohol exposure. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-23
Dietary salt promotes cognitive impairment through tau phosphorylation
54/100 ✓ Peer-reviewed Prevention and risk Nature
Key finding: In mice, a salt-rich diet leads to cognitive dysfunction associated with a nitric oxide deficit in cerebral endothelial cells and cerebral hypoperfusion 7 . +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-23
Efficacy of Group Reminiscence Therapy on Cognition, Depression, Neuropsychiatric Symptoms, and Activities of Daily Living for Patients With Alzheimer Disease
46/100 ✓ Peer-reviewed Treatments Journal of geriatric psychiatry and neurology
Key finding: Significant improvements in depressive and neuropsychiatric symptoms were found in the intervention group compared to the control group ( P t = 2.076, P = .041) and 24 weeks follow-up ( t = 3.834, P = .000) compared to controls.
Full summary, score breakdown and related studies → Original source
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2019-10-22
Insomnia in Older Adults
39/100 ✓ Peer-reviewed Risk factors Current geriatrics reports
Key finding: Insomnia is associated with socioeconomic status, racial and ethnic classification, family relationships, medical and mental health disorders, cognitive function, and dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-10-22
Cerebrospinal fluid and plasma neurofilament light relate to abnormal cognition
52/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: Plasma NFL was related to all domains (P values ≤ .008) except processing speed (P values ≥ .09). +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-21
An audit of dementia education and training in UK health and social care: a comparison with national benchmark standards
41/100 ✓ Peer-reviewed End-of-life care BMC health services research
Key finding: The development of new and existing training and education should take account of subjects that are currently underrepresented and ensure that training reflects the Training Standard Framework and evidence regarding best practice for delivery. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-21
A Systematic Review of Multimodal Non-Pharmacological Interventions for Cognitive Function in Older People with Dementia in Nursing Homes
66/100 ✓ Peer-reviewed Prevention trials Dementia and geriatric cognitive disorders
Key finding: Our review suggests that MNPIs may improve the global, executive function and memory of PWD in NHs. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-10-21
Neurodegenerative Disease Mortality among Former Professional Soccer Players
67/100 ✓ Peer-reviewed How common it is The New England journal of medicine
Key finding: Over a median of 18 years, 1180 former soccer players (15.4%) and 3807 controls (16.5%) died.
Full summary, score breakdown and related studies → Original source
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2019-10-18
Autophagy and synaptic plasticity: epigenetic regulation
39/100 ✓ Peer-reviewed Disease mechanisms Current opinion in neurobiology
Key finding: In neurons, autophagy is crucial to proper axon guidance, vesicular release, dendritic spine architecture, spine pruning and synaptic plasticity and, when dysregulated, is associated with brain disorders, including autism spectrum disorders, and neurodegenerative diseases such as Parkinson's and Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2019-10-18
High-Throughput Mass Spectrometry Assay for Quantifying β-Amyloid 40 and 42 in Cerebrospinal Fluid
48/100 ✓ Peer-reviewed Biomarkers Clinical chemistry
Key finding: The assay had a reportable range of 100 to 25000 pg/mL, a limit of quantification of 100 pg/mL, recoveries between 93% and 111%, and intraassay and interassay CV <15% for both peptides. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-18
Glucagon-Like Peptide-1: A Focus on Neurodegenerative Diseases
47/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in neuroscience
Key finding: The pathogenesis of brain impairment caused by chronic hyperglycemia is complex and includes mitochondrial dysfunction, neuroinflammation, neurotransmitters' alteration, and vascular disease, which lead to cognitive impairment, neurodegeneration, loss of synaptic plasticity, brain aging, and dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-18
Predictive Value of 18F-Florbetapir and 18F-FDG PET for Conversion from Mild Cognitive Impairment to Alzheimer Dementia
48/100 ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: On the basis of the independent validation dataset, the 18 F-FDG PET model yielded a significantly higher predictive value than the amyloid PET model. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-17
Adapting Mobile and Wearable Technology to Provide Support and Monitoring in Rehabilitation for Dementia: Feasibility Case Series
41/100 ✓ Peer-reviewed Cognitive tests and assessment JMIR formative research
Key finding: Smartphones and wearables could provide beneficial and pervasive support and monitoring for rehabilitation among people with dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-17
Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two Distinct Types of ALS/FTD-Linked FUS Mutations
38/100 ✓ Peer-reviewed Clinical safety Molecular cell
Key finding: Here we demonstrate that wild-type FUS binds single-stranded RNA stoichiometrically in a length-dependent manner and that multimers induce highly dynamic interactions with RNA, giving rise to small and fluid condensates. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-17
Reformulating Pro-Oxidant Microglia in Neurodegeneration
41/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of clinical medicine
Key finding: Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered a new subpopulation named disease-associated microglia (DAM). +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-17
Barriers and facilitators to development and implementation of a rural primary health care intervention for dementia: a process evaluation
56/100 ✓ Peer-reviewed Disparities BMC health services research
Key finding: Across all domains, 14 constructs influenced development and implementation.
Full summary, score breakdown and related studies → Original source
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2019-10-17
A Comparison of Users and Nonusers of a Web-Based Intervention for Carers of Older Persons With Alzheimer Disease and Related Dementias: Mixed Methods Secondary Analysis
60/100 ✓ Peer-reviewed Treatments Journal of medical Internet research
Key finding: At baseline, there were no statistically significant differences in demographic characteristics and in outcome variables (HHI, GSES, and SF-12v2 mental component score and physical component score) between users and nonusers. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-10-17
Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model
51/100 ✓ Peer-reviewed Genetics Molecular neurodegeneration
Key finding: These new knock-in strains offer a novel and dynamic tool to study the role of APOE in AD pathogenesis in a spatially and temporally controlled manner. +1 more finding
Full summary, score breakdown and related studies → Original source
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