Newest studies

Therapeutic role of rifampicin in Alzheimer's disease

38/100 ✓ Peer-reviewed Drug development Psychiatry and clinical neurosciences

Key finding: Rifampicin exerts significant brain protective functions in multiple experimental models. +1 more finding

• Treatments

Full summary, score breakdown and related studies → Original source

Sex differences in progression to mild cognitive impairment and dementia in Parkinson's disease

67/100 ✓ Peer-reviewed Mild cognitive impairment Parkinsonism & related disorders

Key finding: This study provides evidence for sex differences in the progression to cognitive impairment in PD, while specific cognitive features become more important indicators of progression with impending conversion to PDD. +2 more findings

• Early Stage
• Other Dementias

Full summary, score breakdown and related studies → Original source

The cost of Alzheimer's disease in China and re-estimation of costs worldwide

63/100 ✓ Peer-reviewed Caregiving Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: China bears a heavy burden of AD costs, which greatly change the estimates of AD cost worldwide. +1 more finding

• Policy

Full summary, score breakdown and related studies → Original source

In vivo 18F-AV-1451 tau PET signal in MAPT mutation carriers varies by expected tau isoforms

59/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: Tau PET shows higher magnitude of binding in MAPT mutation carriers who harbor mutations that are more likely to produce AD-like tau pathology (e.g., in our series, the non-exon 10 families tend to accumulate mixed 3R/4R aggregates). +1 more finding

• Brain Scans
• Genetics

Full summary, score breakdown and related studies → Original source

Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC

54/100 ✓ Peer-reviewed Getting a diagnosis Acta neuropathologica communications

Key finding: These results confirm that αSyn D seeding activity is present in cerebrospinal fluid.

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Neuropsychological differentiation of progressive aphasic disorders

39/100 ✓ Peer-reviewed Prevention trials Journal of neuropsychology

Key finding: We found that simple tasks of sentence ordering, narrative production, and buccofacial praxis were particularly useful in differentiating non-fluent/agrammatic variant PPA (nfvPPA) from other PPA subtypes, whereas a test of single word comprehension was useful in detecting semantic dementia (SD). +3 more findings

Full summary, score breakdown and related studies → Original source

Telehealth Rehabilitation for Cognitive Impairment: Randomized Controlled Feasibility Trial

39/100 ✓ Peer-reviewed Treatments JMIR research protocols

Key finding: Delivery of cognitive rehabilitation by telehealth appeared feasible but required modifications such as greater reliance on caregivers and clients for manipulating materials.

• Clinical Trials
• Early Stage
• Digital Tools

Full summary, score breakdown and related studies → Original source

Will Changes to Medicare Payment Rates Alter Hospice's Cost-Saving Ability?

39/100 ✓ Peer-reviewed Costs and economics Journal of palliative medicine

Key finding: Medicare costs were reduced from hospice election until death using both 2009-2010 and new 2016 payment structures and rates. +4 more findings

• Policy
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

A transcriptomic atlas of aged human microglia

45/100 ✓ Peer-reviewed Genetics Nature communications

Key finding: These findings confirm the existence of an aging-related microglial phenotype in the aged human brain and its involvement in the pathological processes associated with brain aging.

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

In vivo [18F]-AV-1451 tau-PET imaging in sporadic Creutzfeldt-Jakob disease

45/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: In vivo [ 18 F]-AV-1451 PET neuroimaging was performed in 5 patients with sporadic CJD (median age, 66 years [63-74]), and results were compared to cognitively normal (CN) persons (n = 44; median age, 68 years [63-74]) and to participants with very mild Alzheimer disease (AD) dementia (n = 8; median age, 77 years [63-90]). +3 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer's disease (DELCODE)

60/100 ✓ Peer-reviewed Prevention and risk Alzheimer's research & therapy

Key finding: In this publication, we report cognitive and clinical data as well as apolipoprotein E (APOE) genotype and cerebrospinal fluid (CSF) biomarker results of the first 394 baseline data sets. +2 more findings

• Biomarkers
• Genetics

Full summary, score breakdown and related studies → Original source

Synaptic plasticity modulation by circulating peptides and metaplasticity: Involvement in Alzheimer's disease

39/100 ✓ Peer-reviewed Disease mechanisms Pharmacological research

Key finding: In humans, AD is associated at the cellular level with neuropathological lesions composed of extracellular deposits of β-amyloid (Aβ) protein aggregates and intracellular neurofibrillary tangles, cellular loss, neuroinflammation and a general brain homeostasis dysregulation. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Impact of person-centred care training and person-centred activities on quality of life, agitation, and antipsychotic use in people with dementia living in nursing homes: A cluster-randomised controlled trial

80/100 ✓ Peer-reviewed Health systems and care delivery PLoS medicine

Key finding: Costs were calculated using cost function figures compared with usual costs. +4 more findings

• Clinical Trials
• Care Services

Full summary, score breakdown and related studies → Original source

Functional morphology of the blood-brain barrier in health and disease

45/100 ✓ Peer-reviewed Inflammation and the immune system Acta neuropathologica

Key finding: Therefore, the potential influence of CNS blood vessels in neurological diseases associated with BBB alterations or neuroinflammation has become a major focus of current research to understand their contribution to pathogenesis. +1 more finding

• Brain Biology
• Treatments

Full summary, score breakdown and related studies → Original source

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

38/100 ✓ Peer-reviewed Genetics Immunity

Key finding: Individual reports suggest that the central nervous system (CNS) contains multiple immune cell types with diverse roles in tissue homeostasis, immune defense, and neurological diseases. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

NAD + supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

38/100 ✓ Peer-reviewed Disease mechanisms Proceedings of the National Academy of Sciences of the United States of America

Key finding: Emerging findings suggest that compromised cellular bioenergetics and DNA repair contribute to the pathogenesis of Alzheimer's disease (AD), but their role in disease-defining pathology is unclear. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Current Strategies for Brain Drug Delivery

41/100 ✓ Peer-reviewed Risk factors Theranostics

Key finding: The objective of this review is to provide a broad overview on current strategies for brain drug delivery and related subjects from the past five years. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals

60/100 ✓ Peer-reviewed Hippocampus size on brain scans Nature neuroscience

Key finding: Animal models of Alzheimer's disease have suggested that tau pathology propagation, facilitated by amyloid pathology, may occur along connected pathways. +2 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Tandem repeats mediating genetic plasticity in health and disease

48/100 ✓ Peer-reviewed Lewy body dementia Nature reviews. Genetics

Key finding: Accumulating evidence suggests that many classes of DNA repeats exhibit attributes that distinguish them from other genetic variants, including the fact that they are more liable to mutation; this enables them to mediate genetic plasticity. +1 more finding

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons

60/100 ✓ Peer-reviewed Lewy body dementia Nature medicine

Key finding: Using human induced motor neurons (iMNs), we found that repeat-expanded C9ORF72 was haploinsufficient in ALS. +2 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

TREM2 overexpression attenuates neuroinflammation and protects dopaminergic neurons in experimental models of Parkinson's disease

43/100 ✓ Peer-reviewed TREM2 and immune genetics Experimental neurology

Key finding: Several observations support the hypothesis that TREM2 variation may confer susceptibility to Parkinson's disease (PD). +3 more findings

• Brain Biology
• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Two-Year Course of Quality of Life in Nursing Home Residents with Dementia

61/100 ✓ Peer-reviewed Health systems and care delivery The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: No change was found in the Qualidem total score (range: 0-111) over 2 years. +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Efficacy of Cognitive Training in Older Adults with and without Subjective Cognitive Decline Is Associated with Inhibition Efficiency and Working Memory Span, Not with Cognitive Reserve

41/100 ✓ Peer-reviewed Prevention trials Frontiers in aging neuroscience

Key finding: The present study explores the role of cognitive reserve, executive functions, and working memory (WM) span, as factors that might explain training outcomes in cognitive status. +3 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Biomarker pattern of ARIA-E participants in phase 3 randomized clinical trials with bapineuzumab

68/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Baseline biomarkers largely do not predict risk for developing ARIA-E. ARIA-E was associated with significant longitudinal changes in several biomarkers, with larger reductions in amyloid PET and CSF p-tau and t-tau concentrations, and paradoxically greater hippocampal volume reduction and ventricular enlargement, suggesting that ARIA-E in bapineuzumab-treated cases may be related to increased Aβ efflux from the brain and affecting downstream pathogenic processes. +3 more findings

• Clinical Trials
• Biomarkers
• Side Effects

Full summary, score breakdown and related studies → Original source

Atypical Antipsychotics in Late-Life and Treatment-Resistant Depression

39/100 ✓ Peer-reviewed Risk factors The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists

Key finding: Older adults not only have an increased risk of late-life depression, but they also have an increased risk of suicidal ideation. +1 more finding

• Side Effects

Full summary, score breakdown and related studies → Original source