Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 24,251–24,275 of 27,380 studies, newest first · page 971 of 1096.
January 2004 25
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2004 year only
Ocular static and dynamic light scattering: a noninvasive diagnostic tool for eye research and clinical practice
38/100 ✓ Peer-reviewed Brain scans and imaging Journal of biomedical optics
Key finding: The noninvasive techniques of static and dynamic light scattering are emerging as valuable diagnostic tools for the early detection of ocular and systemic diseases. +3 more findings
Full summary, score breakdown and related studies → Original source
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2004 year only
A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity
38/100 ✓ Peer-reviewed Genetics Journal of molecular neuroscience : MN
Key finding: Chronically activated glia associated with amyloid plaques might contribute to neuronal dysfunction in Alzheimer's disease (AD) through generation of neuroinflammatory molecules. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-01-01
Prediction of proprotein convertase cleavage sites
36/100 ✓ Peer-reviewed Digital health tools Protein engineering, design & selection : PEDS
Key finding: Two different types of neural networks have been constructed: a furin-specific network based on experimental results derived from the literature, and a general PC-specific network trained on data from the Swiss-Prot protein database.
Full summary, score breakdown and related studies → Original source
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2004-01-01
Relation of education and occupation-based socioeconomic status to incident Alzheimer's disease
48/100 ✓ Peer-reviewed Disparities American journal of epidemiology
Key finding: In this study, the authors evaluated whether the association between low educational level and increased risk of Alzheimer's disease (AD) and dementia may be explained by occupation-based socioeconomic status (SES). +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-01-01
Neurodegenerative diseases and oxidative stress
36/100 ✓ Peer-reviewed Inflammation and the immune system Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Key finding: Nitric oxide (NO(;)), an RNS, which can be produced by three isoforms of NO-synthase in brain, plays a prominent role. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-01-01
Mapping cortical change in Alzheimer's disease, brain development, and schizophrenia
36/100 ✓ Peer-reviewed Prevention and risk NeuroImage
Key finding: This paper describes algorithms that can identify patterns of brain structure and function associated with Alzheimer's disease, schizophrenia, normal aging, and abnormal brain development based on imaging data collected in large human populations.
Full summary, score breakdown and related studies → Original source
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2004-01-01
Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's disease
36/100 ✓ Peer-reviewed Risk factors Neurobiology of aging
Key finding: The ensuing homeostatic responses to myelin breakdown further increase intracortical toxicity and results in the relentless progression and non-random anatomical distribution of AD lesions that eventually cause neuronal dysfunction and degeneration.
Full summary, score breakdown and related studies → Original source
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2004-01-01
Cholinesterase inhibitors used in the treatment of Alzheimer's disease: the relationship between pharmacological effects and clinical efficacy
36/100 ✓ Peer-reviewed Treatments Drugs & aging
Key finding: There is also a significant correlation between acetylcholinesterase inhibition and observed cognitive improvement. +3 more findings
Full summary, score breakdown and related studies → Original source
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2004-01-01
Passage of VIP/PACAP/secretin family across the blood-brain barrier: therapeutic effects
36/100 ✓ Peer-reviewed Drug development Current pharmaceutical design
Key finding: However, uptake of PACAP 38 into the brain is saturable mechanism. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-01-01
Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brain
36/100 ✓ Peer-reviewed Treatments Current pharmaceutical design
Key finding: In vitro studies indicate that amyloid plaques contain multiple binding sites that can accommodate structurally diverse compounds, providing flexibility for radiopharmaceutical design of amyloid imaging agents. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-01-01
Validity of the Mindstreams computerized cognitive battery for mild cognitive impairment
44/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of molecular neuroscience : MN
Key finding: Mindstreams outcome parameters across multiple cognitive domains significantly discriminated between MCI and healthy elders with considerable effect sizes (p < 0.05).
Full summary, score breakdown and related studies → Original source
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2004-01-01
Epidemiology of fecal incontinence
36/100 ✓ Peer-reviewed Vascular contributions Gastroenterology
Key finding: Specific diseases associated with fecal incontinence include diabetes, multiple sclerosis, Parkinson's disease, stroke, and spinal cord injury. +1 more finding
Full summary, score breakdown and related studies → Original source
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2004-01-01
Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults
36/100 ✓ Peer-reviewed Vascular contributions NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics
Key finding: Past clinical use for other indications has demonstrated that memantine is well tolerated, and it has recently been approved in both Europe and the USA for the treatment of dementia of the Alzheimer's type.
Full summary, score breakdown and related studies → Original source
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2004-01-01
Effects of hypoxia on the brain: neuroimaging and neuropsychological findings following carbon monoxide poisoning and obstructive sleep apnea
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Journal of the International Neuropsychological Society : JINS
Key finding: Neuroimaging revealed evidence of hippocampal atrophy in both groups although a linear relationship between hippocampal volume and memory performance was found only for selected tests and only in the sleep apnea group. +3 more findings
Full summary, score breakdown and related studies → Original source
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2004-01-01
Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible
36/100 ✓ Peer-reviewed Hippocampus size on brain scans The European journal of neuroscience
Key finding: Based on two independent parameters, bromodeoxyuridine (BrdU) and Ki-67 immunocytochemistry, our results show that both chronic and acute stress decrease new cell proliferation rate. +1 more finding
Full summary, score breakdown and related studies → Original source
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2004-01-01
Delayed effects of chronic variable stress during peripubertal-juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Hippocampus
Key finding: Moreover, these volume deficits were associated with impairments in the Morris water-maze navigation, sustained down-regulation in the basal hippocampal glucocorticoid receptor gene expression, and deficits in the shutdown of acute stress-induced corticosterone secretion. +1 more finding
Full summary, score breakdown and related studies → Original source
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2004-01-01
Relationship between hippocampal volume and memory ability in healthy individuals across the lifespan: review and meta-analysis
64/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuropsychologia
Key finding: Numerous studies have examined the relationship between memory performance and hippocampal volumes in participants without neurological or psychiatric disorders, with widely varying results. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-01-01
Advance care planning: preferences for care at the end of life
36/100 ✓ Peer-reviewed End-of-life care Journal of pain & palliative care pharmacotherapy
Key finding: Predictors of patient wishes and influence of family and clinicians are discussed.
Full summary, score breakdown and related studies → Original source
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2004-01-01
Using antipsychotic agents in older patients
36/100 ✓ Peer-reviewed Clinical safety The Journal of clinical psychiatry
Key finding: The expert panel reached consensus on 78% of options rated on the 9-point scale.
Full summary, score breakdown and related studies → Original source
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2004-01-01
Delirium in elderly patients
36/100 ✓ Peer-reviewed Clinical safety The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: It occurs in hyperactive, hypoactive, or mixed forms, in up to 50% of elderly hospital inpatients, many with pre-existing dementia, and appears to be independently associated with significant increases in functional disability, length of hospital stay, rates of admission to long-term care institutions, rates of death, and healthcare costs.
Full summary, score breakdown and related studies → Original source
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2004-01-01
Cognitive rehabilitation in Parkinson's disease
43/100 ✓ Peer-reviewed Prevention trials Archives of gerontology and geriatrics. Supplement
Key finding: At the end of the scheduled sessions, the patients showed a significant improvement at verbal fluency, logic memory and Raven's matrices tests, as compared to baseline. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-01-01
Dementia with Lewy bodies
40/100 ✓ Peer-reviewed Brain tissue and pathology The Lancet. Neurology
Key finding: Severe neuroleptic sensitivity reactions are associated with significantly increased morbidity and mortality.
Full summary, score breakdown and related studies → Original source
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2004 no date recorded — placed by publication year
Tai Chi Adapted: Assisted Living, Long-Term Care, and Nursing Homes
25/100 ✓ Peer-reviewed Health systems and care delivery Home Health Care Management & Practice
Key finding: This article is written to help bridge classic Chinese health care systems with the current complementary/alternative medical point of view. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-01-01
The Abbey pain scale: a 1-minute numerical indicator for people with end-stage dementia
44/100 ✓ Peer-reviewed Brain tissue and pathology International journal of palliative nursing
Key finding: Structured approaches to palliative care are not well developed. +3 more findings
Full summary, score breakdown and related studies → Original source
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2004-01-01
A "mitochondrial cascade hypothesis" for sporadic Alzheimer's disease
46/100 ✓ Peer-reviewed Brain tissue and pathology Medical hypotheses
Key finding: Recent studies also show excess neuronal aneuploidy, programmed cell death (PCD), and mitochondrial dysfunction. +3 more findings
Full summary, score breakdown and related studies → Original source
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