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TREM2 suppresses the proinflammatory response to facilitate PRRSV infection via PI3K/NF-κB signaling
Zhu Z, Zhang X, Dong W, Wang X, He S, Zhang H, Wang X, Wei R et al.. PLoS pathogens, 2020-05-13
Topic: Brain proteins, microglia and lab models
Triggering receptor expressed on myeloid cells 2 (TREM2) serves as an anti-inflammatory receptor, negatively regulating the innate immune response. TREM2 is mainly expressed on dendritic cells and macrophages, the target cells of porcine reproductive and respiratory syndrome virus (PRRSV). Thus, we investigated the potential role of TREM2 in PRRSV infection in porcine alveolar macrophages (PAMs).
Key findings
- TREM2 is mainly expressed on dendritic cells and macrophages, the target cells of porcine reproductive and respiratory syndrome virus (PRRSV).
- Thus, we investigated the potential role of TREM2 in PRRSV infection in porcine alveolar macrophages (PAMs).
- We found that there was an increased expression of TREM2 upon PRRSV infection in vitro.
- TREM2 silencing restrained the replication of PRRSV, whereas TREM2 overexpression facilitated viral replication.
Why it matters
In pig cells, TREM2 acted as an anti-inflammatory receptor and its presence helped a virus called PRRSV replicate, while silencing TREM2 restrained the virus. This is infectious disease research in animals and does not directly inform Alzheimer's treatment, cure or prevention.
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Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (PLoS pathogens) |
| Journal's citation record | 3 / 4 | PLoS Pathogens: journal h-index 315 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 90 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 11.2 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 3 / 6 | Cited 6.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 3 / 4 | Cited 52 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Chunhe Guo: h-index 18 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Sun Yat-sen University: institution h-index 851 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32401783) |
| Free to read | 2 / 2 | Free to read |
| Total | 43 / 100 | — |
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Read the original
- DOI: 10.1371/journal.ppat.1008543
- PubMed: 32401783
- Original source →
- Free full text: PLoS Pathogens →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Zhu, Z., Zhang, X., Dong, W., Wang, X., He, S., Zhang, H., et al. (2020). TREM2 suppresses the proinflammatory response to facilitate PRRSV infection via PI3K/NF-κB signaling. PLoS pathogens. https://doi.org/10.1371/journal.ppat.1008543
Vancouver
Zhu Z, Zhang X, Dong W, Wang X, He S, Zhang H, et al. TREM2 suppresses the proinflammatory response to facilitate PRRSV infection via PI3K/NF-κB signaling. PLoS pathogens. 2020. doi:10.1371/journal.ppat.1008543. PMID: 32401783.
BibTeX
@article{zhu2020-32401783,
author = {Zhu, Z. and Zhang, X. and Dong, W. and Wang, X. and He, S. and Zhang, H. and Wei, R. and others},
title = {{TREM2 suppresses the proinflammatory response to facilitate PRRSV infection via PI3K/NF-κB signaling}},
journal = {PLoS pathogens},
year = {2020},
doi = {10.1371/journal.ppat.1008543},
pmid = {32401783},
url = {https://doi.org/10.1371/journal.ppat.1008543}
}
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