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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 24,126–24,150 of 27,380 studies, newest first · page 966 of 1096.

May 2004 12

  1. 2004-05-01

    Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice

    ✓ Peer-reviewed Risk genes beyond APOE Journal of neuropathology and experimental neurology

    Key finding: Double transgenic (Tg) mice co-expressing the M146L presenilin 1 (PS1) and K670N/M671L, the double "Swedish" amyloid precursor protein (APP) mutations, are a model of AD amyloid-beta deposition (Abeta) that exhibits earlier and more profound impairments of working memory and learning than single APP mutant mice. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2004-05-01

    Acetylcholinesterase and its inhibition in Alzheimer disease

    ✓ Peer-reviewed Risk genes beyond APOE Clinical neuropharmacology

    Key finding: Therefore, the use of AChE inhibitors to treat symptoms caused by cholinergic imbalances in Alzheimer disease (AD) represented a rational approach. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2004-05-01

    Dendrite and dendritic spine alterations in Alzheimer models

    ✓ Peer-reviewed Risk genes beyond APOE Journal of neurocytology

    Key finding: Multicolor DiOlistic labeling of the hippocampus has been undertaken which allows the full dendritic arbor of targeted neurons to be imaged. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2004-05-01

    Amyloid beta-peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease

    ✓ Peer-reviewed Risk genes beyond APOE Journal of peptide science : an official publication of the European Peptide Society

    Key finding: By virtue of its structure, Abeta is able to bind to a variety of biomolecules, including lipids, proteins and proteoglycans. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2004-05-01

    A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of clinical investigation

    Key finding: In the nonamyloidogenic pathway, the amyloid precursor protein (APP) is cleaved by the alpha-secretase within the A beta peptide sequence. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2004-05-01

    Sleep and quantitative EEG in neurodegenerative disorders

    ✓ Peer-reviewed Risk factors Journal of psychosomatic research

    Key finding: This paper reviews current knowledge on sleep problems, sleep architecture changes and quantitative EEG alteration brought on by various neurodegenerative diseases, such as Alzheimer's disease (AD), progressive supranuclear palsy (PSP), REM sleep behavior disorder (RBD), Parkinson's disease (PD), dementia with Lewy bodies (DLB), multiple system atrophy MSA, Huntington's disease and Creutzfeldt-Jakob disease, in comparison to normal aging. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2004-05-01

    Inflammatory proteins in plasma and the risk of dementia: the rotterdam study

    ✓ Peer-reviewed How common it is Archives of neurology

    Key finding: Plasma levels of inflammatory proteins are increased before clinical onset of dementia, Alzheimer disease, and vascular dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2004-05-01

    Treatment of nursing home residents with dementia and lower respiratory tract infection in the United States and The Netherlands: an ocean apart

    ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society

    Key finding: Care for U.S. nursing home residents with LRI and dementia is more aggressive than care for Dutch residents, particularly in residents with severe dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2004-05-01

    Family caregiving of persons with dementia: prevalence, health effects, and support strategies

    ✓ Peer-reviewed Caregiving The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    Key finding: As a result, family members are increasingly being asked to perform complex tasks similar to those carried out by paid health or social service providers, often at great cost to their own well-being and great benefit to their relatives and society as a whole. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2004-05-01

    Midlife dietary intake of antioxidants and risk of late-life incident dementia: the Honolulu-Asia Aging Study

    ✓ Peer-reviewed Prevention and risk American journal of epidemiology

    Key finding: Intakes of beta-carotene, flavonoids, and vitamins E and C were not associated with the risk of dementia or its subtypes. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2004-05-01

    Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County Study

    ✓ Peer-reviewed Genetics Archives of general psychiatry

    Key finding: The APOE epsilon4 allele acts as a potent risk factor for AD by accelerating onset.

    Full summary, score breakdown and related studies → Original source

  12. 2004-05-01

    Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Neurobiology of aging

    Key finding: Immunohistochemical analyses have suggested that astrocytes overburdened with these internalized materials can eventually undergo lysis, and radial dispersal of their cytoplasmic contents, including Abeta42, can lead to the deposition of a persistent residue in the form of small, GFAP-rich, astrocytic amyloid plaques, first appearing in the molecular layer of the cerebral cortex. +1 more finding

    Full summary, score breakdown and related studies → Original source

April 2004 13

  1. 2004-04-29

    Dementia after stroke: the Framingham Study

    ✓ Peer-reviewed Prevention and risk Stroke

    Key finding: Stroke increases a subject's risk of dementia as compared with age- and sex-matched controls. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2004-04-22

    S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

    ✓ Peer-reviewed Lewy body dementia Science (New York, N.Y.)

    Key finding: Parkin is an E3 ubiquitin ligase involved in the ubiquitination of proteins that are important in the survival of dopamine neurons in Parkinson's disease (PD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2004-04-21

    'In the course of time': a PET study of the cerebral substrates of autobiographical amnesia in Alzheimer's disease

    ✓ Peer-reviewed Disease mechanisms Brain : a journal of neurology

    Key finding: Neuroimaging studies in healthy subjects have yielded controversial results about the neural substrates of autobiographical memory. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2004-04-20

    Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide

    ✓ Peer-reviewed Inflammation and the immune system Journal of neuroinflammation

    Key finding: Roles for excitotoxicity and inflammation in Alzheimer's disease have been hypothesized. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2004-04-14

    Ultrastructural hippocampal and white matter alterations in mild cognitive impairment: a diffusion tensor imaging study

    ✓ Peer-reviewed Mild cognitive impairment Dementia and geriatric cognitive disorders

    Key finding: MCI patients showed higher MD values in the left centrum semiovale (p = 0.013; right: p = 0.026), in the left temporal (p = 0.006), the right temporal (p = 0.014) and the left hippocampal (p = 0.002) region as compared to the control group. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2004-04-08

    Endogenous production of hydrogen sulfide in mammals

    ✓ Peer-reviewed Down syndrome and Alzheimer's Amino acids

    Key finding: Hydrogen sulfide is one of three gases involved in biological functions and synthesized in vivo. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2004-04-07

    Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain

    ✓ Peer-reviewed Disease mechanisms Journal of Neuroscience

    Key finding: Intraneuronal Abeta42 accumulation is also associated with neurodegeneration. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2004-04-06

    Effects of cholinergic drugs and cognitive training on dementia

    ✓ Peer-reviewed Prevention trials Dementia and geriatric cognitive disorders

    Key finding: Subjects underwent test-retest with the following tests: Mini-Mental State Examination (MMSE), the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-cog); the Geriatric Depression Scale (GDS) and the overall deterioration scale (FAST). +1 more finding

    Full summary, score breakdown and related studies → Original source

  9. 2004-04-01

    ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

    ✓ Peer-reviewed Prevention and risk Science (New York, N.Y.)

    Key finding: These data suggest that the ABAD-Abeta interaction may be a therapeutic target in AD.

    Full summary, score breakdown and related studies → Original source

  10. 2004-04-01

    Motor cortex hyperexcitability to transcranial magnetic stimulation in Alzheimer's disease

    ✓ Peer-reviewed Treatments Journal of neurology, neurosurgery, and psychiatry

    Key finding: The change in threshold did not seem to correlate with dysfunction of inhibitory intracortical cholinergic and GABAergic circuits, nor with the central cholinergic activity. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2004-04-01

    Differential vulnerability of anterior white matter in nondemented aging with minimal acceleration in dementia of the Alzheimer type: evidence from diffusion tensor imaging

    ✓ Peer-reviewed Brain scans and imaging Cerebral cortex (New York, N.Y. : 1991)

    Key finding: These data revealed age differences in anisotropy and diffusivity in all assessed regions. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2004-04-01

    Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

    ✓ Peer-reviewed Risk genes beyond APOE Neuron

    Key finding: These deficits are associated with specific reductions in NMDA receptor-mediated responses and synaptic levels of NMDA receptors and alphaCaMKII. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2004-04-01

    Late-onset seizures as a predictor of subsequent stroke

    ✓ Peer-reviewed Vascular contributions Lancet (London, England)

    Key finding: Log-rank testing, adjusted for matching, showed a highly significant difference in stroke-free survival between the two groups (p<0.0001). +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →