SCAI expert consensus statement on out… | 2020

This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

68/100

✓ Peer-reviewed alzhub usefulness score 68 out of 100. Risk factors

Topic: Risk, prevention and care in population studies

Plain-language summary

Out of hospital cardiac arrest (OHCA) remains a significant public health problem with high mortality and morbidity. While emergent angiography and PCI are indicated in selected OHCA patients when the post resuscitation electrocardiogram (ECG) shows ST-segment elevation myocardial infraction (STEMI), there are significant institutional and individual variations in performance and timing for those patients without STEMI on post resuscitation ECG. Factors associated with favorable prognosis: Younger age, initial shockable rhythm, less time to ROSC, no cardiogenic shock YES OR 0.66, 95% CI 0.58,0.75) YES OR – 2.85, 95% CI. – 2.04 – 4.0) NO HR – 0.69, 95% CI – 0.35 – 1.37 Inc: Comatose OHCA patients + Initial Shockable Rhythm + No STEMI of ECG Ex: Shock/obvious noncardiac cause Immediate: Upon presentation Delayed: After neurological recovery Inc: Comatose OHCA patients + Initial Shockable Rhythm + No STEMI on ECG Ex: STEMI Immediate: Admission to Cath Lab Delayed: Admission to ICU for further assessment Inc: Witnessed OHCA with achieving ROSC >20 min Exc: STEMI/obvious noncardiac cause Immediate: Within 120 min Not Immediate: No angiography or after 3 days Open Label, Multicenter, United States Inc: Comatose OHCA patients with No STEMI Ex: STEMI/obvious noncardiac etiology Interventional Early angiography: Within 120 min Control group: After 6 hr Inc: Comatose OHCA patients Ex: STEMI on ECG/obvious noncardiac etiology Immediate: Upon presentation Delayed: 46–96 hr Open Label, Multicenter, Germany Inc: Comatose OHCA patients Ex: STEMI/Hemodynamic Instablity Immediate: Upon presentation Delayed: After 24 hr/neurological recovery Open Label, Multicenter, Spain Inc: Comatose OHCA patients Ex: STEMI/Hemodynamic Instability Urgent: Upon presentations Deferred: After neurological Recovery Irrespective of initial rhythm or ECG findings, the predominant cause of death in two-thirds of patients with OHCA is due to anoxic brain injury and another one-third is due to a refractory post arrest shock and multi-organ failure.4 The rate of survival to discharge with good neurologic function among OHCA patients is low with wide geographical variation estimated at 0.8–20%.5 Anoxic brain injury and postcardiac arrest shock share common risk factors that are related to the timing and quality of pre hospital care.6 Among OHCA patients who are comatose after return of spontaneous circulation (ROSC), there is no single factor at the time of presentation to reliably prognosticate sub

What this study adds

Evidence grade: High

This is a pooled review of 1,410 participants. This consensus statement is about out-of-hospital cardiac arrest and does not address treating, curing, or preventing Alzheimer's disease. Reported effect size: OR 0.66; 18.9%; 7.1%.

Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Lotfi, A. S., Klein, L. W., Hira, R. S., Mallidi, J. R., Mehran, R., Messenger, J. C., et al. (2020). SCAI expert consensus statement on out of hospital cardiac arrest. Catheterization and Cardiovascular Interventions. https://doi.org/10.1002/ccd.28990

Vancouver

Lotfi AS, Klein LW, Hira RS, Mallidi JR, Mehran R, Messenger JC, et al. SCAI expert consensus statement on out of hospital cardiac arrest. Catheterization and Cardiovascular Interventions. 2020. doi:10.1002/ccd.28990. PMID: 32406999.

BibTeX

@article{lotfi2020-32406999,
  author  = {Lotfi, Amir S. and Klein, Lloyd W. and Hira, Ravi S. and Mallidi, Jaya Reddy and Mehran, Roxana and Messenger, John C. and Pinto, Duane S. and Mooney, Michael R and others},
  title   = {{SCAI expert consensus statement on out of hospital cardiac arrest}},
  journal = {Catheterization and Cardiovascular Interventions},
  year    = {2020},
  doi     = {10.1002/ccd.28990},
  pmid    = {32406999},
  url     = {https://doi.org/10.1002/ccd.28990}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

How to read this study

Design: this is a pooled review. It combines earlier studies, so it is only as good as the studies it pools. Check how many were included, whether they were similar enough to combine, and whether the authors report inconsistency between them.
Size: the record lists 1,410 participants. Ask whether that is enough for the question, and who they were.
Effect: the record reports “OR 0.66; 18.9%; 7.1%”. A statistically significant result can still be small in daily life.

What the evidence grade means here

This page is graded high. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. High means the abstract mentions a randomized design, a meta-analysis or a systematic review. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

New to reading papers? Six questions to ask of any Alzheimer’s study · how we score.

Key findings

Out of hospital cardiac arrest (OHCA) remains a significant public health problem with high mortality and morbidity.
While emergent angiography and PCI are indicated in selected OHCA patients when the post resuscitation electrocardiogram (ECG) shows ST-segment elevation myocardial infraction (STEMI), there are significant institutional and individual variations in performance and timing for those patients without STEMI on post resuscitation ECG.
Factors associated with favorable prognosis: Younger age, initial shockable rhythm, less time to ROSC, no cardiogenic shock YES OR 0.66, 95% CI 0.58,0.75) YES OR – 2.85, 95% CI. – 2.04 – 4.0) NO HR – 0.69, 95% CI – 0.35 – 1.37 Inc: Comatose OHCA patients + Initial Shockable Rhythm + No STEMI of ECG
While accurate prognostication is important to avoid pursuing futile treatments or inappropriately withdrawing treatment in patients with a chance of recovery, the quality of existing neurological prognostication studies is insufficient to make any definitive recommendations for long term neurologic outcomes.7 Nevertheless, there are pre and intra arrest factors associated with unfavorable neurological outcomes (Table 3).8, 9 When deciding whether to offer invasive treatments, it is prudent to consider presence of co-morbidities that portend unfavorable short- and long-term prognoses, such as advanced age, severe dementia, chronic advanced respiratory failure, severe frailty or disability, end stage renal or liver disease, and advanced metastatic malignancy.10 Risk stratification scores are often used in medicine for prognostication and decision-making.11 The Cardiac Arrest Hospital Prognosis score (CAHP),12 CREST, and13 C-GRApH are risk stratification tools to assist in decision-making.14 (Table 4).
Anoxic encephalopathy Intracranial bleeding Subarachnoid hemorrhage Post myocardial infarction complications Pulmonary embolus Pericardial tamponade/effusions Valvular dysfunction Regional wall motion abnormalities Hypertrophic cardiomyopathy Given the heterogeneous nature of OHCA patients, fluidity in evolution of the clinical course, and uncertainty associated with neurological prognostication, we advocate a path of “Situational Awareness and Assessment”17 taking into consideration all the clinical factors available to aid in clinical decision-making along the continuum of care of these patients (Figure 1).17 We advocate confirming all the prehospital and hospital clinical history and data, considering carefully patient's comorbidities, patient's and family wishes if known as well as all of the favorable and unfavorable prognostic factors, synthesizing the data to provide the best possible prediction regarding the etiology of the arrest and anticipated neurological and hemodynamic outcomes to help guide the role and timing of invasive strategy in these patients (Figure 1).

Why it matters

This consensus statement is about out-of-hospital cardiac arrest and does not address treating, curing, or preventing Alzheimer's disease. It reports no findings on Alzheimer's disease.

New to this subject? Start with our plain-English guide: Risk factors, ranked →

Study details

Study designmeta-analysis
Participants1,410
Effect sizeOR 0.66; 18.9%; 7.1%
Evidence strengthHigh

How this study scored 68/100

Published in a peer-reviewed journal, and it is a meta-analysis pooling many studies.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Catheterization and Cardiovascular Interventions)
Journal's citation record	1 / 4	Catheterization and Cardiovascular Interventions: journal h-index 144 (OpenAlex, 2026-10-29)
Study design	12 / 12	A meta-analysis pooling many studies
Strength of evidence	5 / 5	Rated “high” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2020 — within 10 year(s) of the newest study here
Sample size	3 / 4	1,410 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	A review of other studies — randomization is not credited here
Times cited	3 / 7	Cited 34 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	4.2 citations a year over 8 year(s) since 2020
Impact for its field and year	3 / 6	Cited 5.6× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 10 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Sean van Diepen: h-index 57 (OpenAlex, whole career)
Institution's track record	3 / 3	University of Washington: institution h-index 3,540 (OpenAlex)
Multicenter collaboration	3 / 3	OpenAlex lists 12 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 32406999)
Free to read	2 / 2	Free to read
Total	68 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Studies in the library that share something with this one. The line above each title says what.

Related studies in Risk factors from nearby years

Also tagged “palliative”

858 studies in the library carry the topic tag “palliative”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 858 tagged studies.

Studies sharing this one's topic tags

Similar studies

More on Risk factors

See all studies in Risk factors →