alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 9,901–9,925 of 27,380 studies, newest first · page 397 of 1096.

August 2021 25

  1. 2021-08-13

    LIM-Kinases in Synaptic Plasticity, Memory, and Brain Diseases

    ✓ Peer-reviewed Disease mechanisms Cells

    Key finding: Accumulating evidence indicates that LIMKs are critically involved in brain function and dysfunction.

    Full summary, score breakdown and related studies → Original source

  2. 2021-08-13

    Magnetic Resonance Imaging of Blood-Brain Barrier permeability in Dementia

    ✓ Peer-reviewed Vascular contributions Neuroscience

    Key finding: Alzheimer's disease (AD) and cerebral small vessel disease (cSVD) are the two main causes of dementia with blood-brain barrier (BBB) breakdown being a common contributor. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2021-08-13

    Characterizing Macrophage Diversity in Metastasis-Bearing Lungs Reveals a Lipid-Associated Macrophage Subset

    ✓ Peer-reviewed TREM2 and immune genetics Cancer research

    Key finding: Here, macrophages were isolated from the lungs of mice bearing orthotopic mammary tumors for single-cell RNA sequencing (scRNA-seq). +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-08-12

    Proteomic landscape of Alzheimer's Disease: novel insights into pathogenesis and biomarker discovery

    ✓ Peer-reviewed Genetics Molecular neurodegeneration

    Key finding: We discuss the hypothesized protective or detrimental roles of selected DE proteins, emphasizing top proteins in "amyloidome" (all biomolecules in amyloid plaques) and disease progression. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2021-08-12

    Postacute care outcomes in home health or skilled nursing facilities in patients with a diagnosis of dementia

    ✓ Peer-reviewed End-of-life care Health services research

    Key finding: Medicare beneficiaries with a diagnosis of dementia receiving postacute care in HH or SNF experienced similar rates of readmission and mortality across settings. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2021-08-12

    Ordinal SuStaIn: Subtype and Stage Inference for Clinical Scores, Visual Ratings, and Other Ordinal Data

    ✓ Peer-reviewed Long-term cohort studies Frontiers in artificial intelligence

    Key finding: SuStaIn has been used to identify data-driven subgroups and perform patient stratification in neurodegenerative diseases and in lung diseases from continuous biomarker measurements predominantly obtained from imaging. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2021-08-12

    Tau-PET and in vivo Braak-staging as prognostic markers of future cognitive decline in cognitively normal to demented individuals

    ✓ Peer-reviewed Mild cognitive impairment Alzheimer's research & therapy

    Key finding: In this longitudinal study, we included 396 cognitively normal to dementia subjects with 18 F-Florbetapir/ 18 F-Florbetaben-amyloid-PET, 18 F-Flortaucipir-tau-PET and ~ 2-year cognitive follow-up.

    Full summary, score breakdown and related studies → Original source

  8. 2021-08-11

    Savings and outcomes under Medicare's bundled payments initiative for skilled nursing facilities

    ✓ Peer-reviewed Costs and economics Journal of the American Geriatrics Society

    Key finding: Our sample included 1001 participating and 3873 matched control SNFs. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2021-08-11

    Preclinical in vivo longitudinal assessment of KG207-M as a disease-modifying Alzheimer's disease therapeutic

    ✓ Peer-reviewed Biomarkers Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    Key finding: In vivo biomarker abnormalities provide measures to monitor therapeutic interventions targeting amyloid-β pathology as well as its effects on downstream processes associated with Alzheimer's disease pathophysiology.

    Full summary, score breakdown and related studies → Original source

  10. 2021-08-11

    The prevalence and incidence of early-onset dementia among adults with autism spectrum disorder

    ✓ Peer-reviewed Digital health tools Autism research : official journal of the International Society for Autism Research

    Key finding: This prevalence was higher compared to the prevalence of dementia in individuals with no ASD and no ID (0.97%), but lower compared to individuals with ID only (7.10%). +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2021-08-11

    Nursing home admissions for persons with dementia: Role of home‐ and community‐based services

    ✓ Peer-reviewed Risk factors Health Services Research

    Key finding: Considerable variations of breadth and intensity in county-level HCBS were observed. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2021-08-11

    Smart Home Sensing and Monitoring in Households With Dementia: User-Centered Design Approach

    ✓ Peer-reviewed Digital health tools JMIR aging

    Key finding: A thematic analysis revealed factors that motivate household members to use these technologies. +2 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2021-08-11

    Association of Dipeptidyl Peptidase-4 Inhibitor Use and Amyloid Burden in Patients With Diabetes and AD-Related Cognitive Impairment

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: These findings suggest that DPP-4i use is associated with low amyloid burden and favorable long-term cognitive outcome in diabetic patients with ADCI. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2021-08-10

    The impact of COVID-19 in an assisted living community

    ✓ Peer-reviewed Health systems and care delivery Geriatric nursing (New York, N.Y.)

    Key finding: No significant change was noted in function or behavioral symptoms but there was a statistically significant decline in cognition over the 12 month period. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2021-08-09

    Curiosity-Based Interventions Increase Everyday Functioning Score But Not Serum BDNF Levels in a Cohort of Healthy Older Adults

    ✓ Peer-reviewed Tau biomarkers Frontiers in aging

    Key finding: Environmental enrichment increases brain-derived neurotrophic factor (BDNF) in aged rats and reduces levels of Alzheimer-related proteins in the blood, including amyloid-β (Aβ) peptides and misfolded toxic forms of tau. +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2021-08-09

    Alzheimer's Disease and Frontotemporal Dementia: A Robust Classification Method of EEG Signals and a Comparison of Validation Methods

    ✓ Peer-reviewed Digital health tools Diagnostics (Basel, Switzerland)

    Key finding: Another dementia type is frontotemporal dementia (FTD), which is associated with circumscribed degeneration of the prefrontal and anterior temporal cortex and mainly affects personality and social skills.

    Full summary, score breakdown and related studies → Original source

  17. 2021-08-09

    Repeated Transcranial Magnetic Stimulation for Improving Cognition in Alzheimer Disease: Protocol for an Interim Analysis of a Randomized Controlled Trial

    ✓ Peer-reviewed Treatments JMIR research protocols

    Key finding: Overall, the study with the same protocol is going as expected with no serious AE or any major protocol deviation. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2021-08-08

    Neurogranin as biomarker in CSF is non-specific to Alzheimer's disease dementia

    ✓ Peer-reviewed Tau biomarkers Neurobiology of aging

    Key finding: Median[IQR] Ng concentrations were elevated in AD (414[315-499]pg/mL) and non-AD (464[319-699]pg/mL) compared to controls (260[193-306]pg/mL), but highest in AD-high-T-tau (874[716, 1148] pg/mL) and Creutzfeldt-Jakob disease (CJD; 828[703-1373]pg/mL) in cohort 1 (p < 0.01), but not in cohort 2: AD: 358[249-470]pg/mL; non-AD:245[137-416]pg/mL; controls: 259[193-370]pg/mL. +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2021-08-07

    Systematic Assessment of 10 Biomarker Candidates Focusing on α-Synuclein-Related Disorders

    ✓ Peer-reviewed Biomarkers Movement disorders : official journal of the Movement Disorder Society

    Key finding: NfL, pNfH, UCHL-1, GFAP, S100B, and sTREM-2 were increased in patients with neurodegenerative disease versus HC (P < 0.05). +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2021-08-07

    The antagonistic pleiotropy of insulin-like growth factor 1

    ✓ Peer-reviewed Long-term cohort studies Aging cell

    Key finding: In this study, we used the UK Biobank (n = 440,185) to resolve previous ambiguities in the relationship between serum IGF-1 levels and clinical disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2021-08-06

    Basal forebrain cholinergic system in the dementias: Vulnerability, resilience, and resistance

    ✓ Peer-reviewed Disease mechanisms Journal of neurochemistry

    Key finding: This review summarizes the relevance to BFCN of neuropathologic markers associated with dementias, including the plaques and tangles of Alzheimer's disease (AD), the Lewy bodies of diffuse Lewy body disease, the tauopathy of frontotemporal lobar degeneration (FTLD-TAU) and the TDP-43 proteinopathy of FTLD-TDP.

    Full summary, score breakdown and related studies → Original source

  22. 2021-08-06

    Five-year outcomes after IVIG for mild cognitive impairment due to alzheimer disease

    ✓ Peer-reviewed Treatments BMC neuroscience

    Key finding: An eight-week course of IVIG totaling 2 g/kg in MCI is safe but is not sufficient to sustain an initial reduction in brain atrophy or a temporary delay in conversion to dementia at five years.

    Full summary, score breakdown and related studies → Original source

  23. 2021-08-06

    Metabolite Signature of Alzheimer's Disease in Adults with Down Syndrome

    ✓ Peer-reviewed Biomarkers Annals of neurology

    Key finding: Magnetic resonance spectroscopy detects Alzheimer's disease related inflammation and neurodegeneration, and could be a good noninvasive disease-stage biomarker in Down syndrome. +2 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2021-08-05

    Nutrition, Gut Microbiota, and Alzheimer's Disease

    ✓ Peer-reviewed Disease mechanisms Frontiers in psychiatry

    Key finding: Nutrition is known to play an important role in the pathogenesis of Alzheimer's disease. +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2021-08-05

    Polygenic score modifies risk for Alzheimer's disease in APOE ε4 homozygotes at phenotypic extremes

    ✓ Peer-reviewed Genetics Alzheimer's & dementia (Amsterdam, Netherlands)

    Key finding: The PRS for AD was significantly higher in APOE ε4 homozygote AD cases compared to older cognitively healthy APOE ε4/ε4 controls (odds ratio [OR] 8.39; confidence interval [CI] 2.0-35.2; P = .003). +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →