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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 9,851–9,875 of 27,380 studies, newest first · page 395 of 1096.

September 2021 8

  1. 2021-09-01

    Global Prevalence of Young-Onset Dementia: A Systematic Review and Meta-analysis

    ✓ Peer-reviewed How common it is JAMA neurology

    Key finding: A total of 95 unique studies were included in this systematic review, of which 74 with 2 760 379 unique patients were also included in 5-year age band meta-analyses. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2021-09-01

    Obstructive sleep apnea treatment and dementia risk in older adults

    ✓ Peer-reviewed Disparities Sleep

    Key finding: Study objectives To examine associations between positive airway pressure (PAP) therapy, adherence and incident diagnoses of Alzheimer's disease (AD), mild cognitive impairment (MCI), and dementia not otherwise specified (DNOS) in older adults. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2021-09-01

    Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study

    ✓ Peer-reviewed Getting a diagnosis The Lancet. Neurology

    Key finding: Plasma p-tau217 and p-tau181 were correlated (r=0·90, p diff =0·31) and in pathology-confirmed Alzheimer's disease (n=15, mean age 73 years [SD 12]) versus pathologically confirmed FTLD (n=68, mean age 67 years [SD 8]; AUC=0·96 [0·92-1·00] for p-tau217, AUC=0·91 [0·82-1·00] for p-tau181; p diff =0·22). +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-09-01

    Investigation of combined treatment of acupuncture and neurofeedback for improving cognitive function in mild neurocognitive disorder: A randomized, assessor-blind, pilot study

    ✓ Peer-reviewed Treatments Medicine

    Key finding: We will evaluate the effectiveness and safety of combined NF-acupuncture therapy, and expect that it will serve as the basis for the use of NF together with acupuncture in the clinical setting.

    Full summary, score breakdown and related studies → Original source

  5. 2021-09-01

    The Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer Disease and Other Dementias (TRAIN-AD): A Cluster Randomized Clinical Trial

    ✓ Peer-reviewed Treatments JAMA internal medicine

    Key finding: This cluster randomized clinical trial found that despite high adherence to the training, a multicomponent intervention promoting goal-directed care for suspected UTIs and LRIs did not significantly reduce antimicrobial use among nursing home residents with advanced dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2021-09-01

    Proportion of Women and Reporting of Outcomes by Sex in Clinical Trials for Alzheimer Disease: A Systematic Review and Meta-analysis

    ✓ Peer-reviewed Treatments JAMA network open

    Key finding: In this review of 56 RCTs for AD involving 39 575 participants, 23 348 women (59.0%) were included. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2021-09-01

    Comparison of Plasma Phosphorylated Tau Species With Amyloid and Tau Positron Emission Tomography, Neurodegeneration, Vascular Pathology, and Cognitive Outcomes

    ✓ Peer-reviewed Biomarkers JAMA neurology

    Key finding: In this largely presymptomatic population, these results suggest subtle differences across plasma p-tau species and platforms for the prediction of amyloid and tau PET and magnetic resonance imaging measures of cerebrovascular and Alzheimer-related pathology. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2021-09 month only

    Global Prevalence of Young-Onset Dementia: A Systematic Review and Meta-analysis

    ✓ Peer-reviewed How common it is JAMA Neurology

    Key finding: Global age-standardized prevalence of young-onset dementia (ages 30-64) was 119.0 per 100,000 population +3 more findings

    Full summary, score breakdown and related studies → Original source

August 2021 17

  1. 2021-08-31

    Treatment of insomnia - effect of trazodone and hypnotics on sleep

    ✓ Peer-reviewed Risk factors Psychiatria polska

    Key finding: Trazodone increases the duration of deep sleep, which is associated with better sleep quality as assessed by patients. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2021-08-31

    Glucagon-Like Peptide-1 Receptor Agonists and Brain Vascular Function

    ✓ Peer-reviewed Drug development Heart, lung & circulation

    Key finding: Prevention of cardiovascular events and regression of atherosclerotic changes are the primary aims of preventive cardiovascular medicine. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2021-08-31

    Hippocampal glucose uptake as a surrogate of metabolic change of microglia in Alzheimer's disease

    ✓ Peer-reviewed TREM2 and immune genetics Journal of neuroinflammation

    Key finding: Here, we found a close association of the metabolic reconfiguration of microglia with increased hippocampal glucose uptake on [ 18 F]fluorodeoxyglucose (FDG) PET. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-08-31

    Detection of dementia on voice recordings using deep learning: a Framingham Heart Study

    ✓ Peer-reviewed Digital health tools Alzheimer's research & therapy

    Key finding: This proof-of-concept study demonstrates that automated deep learning-driven processing of audio recordings of neuropsychological testing performed on individuals recruited within a community cohort setting can facilitate dementia screening. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2021-08-31

    Overview of the Complex Figure Test and Its Clinical Application in Neuropsychiatric Disorders, Including Copying and Recall

    ✓ Peer-reviewed Digital health tools Frontiers in neurology

    Key finding: It is widely used to assess the visuo-constructional ability and visual memory of neuropsychiatric disorders, including copying and recall tests. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2021-08-30

    Apolipoprotein E and Alzheimer's Disease: Findings, Hypotheses, and Potential Mechanisms

    ✓ Peer-reviewed Digital health tools Annual review of pathology

    Key finding: Although the exact mechanisms underlying apoE4 effects on AD initiation and progression are not fully understood, recent studies have revealed critical insights into the apoE4-induced deficits that occur in AD.

    Full summary, score breakdown and related studies → Original source

  7. 2021-08-30

    Brain Network Integrity Changes in Subjective Cognitive Decline: A Possible Physiological Biomarker of Dementia

    ✓ Peer-reviewed Cognitive tests and assessment Frontiers in neurology

    Key finding: Both DELPHI analysis of network function and DTI analysis detected a significant decrease in connectivity, excitability, and WM integrity in the SCD group compared to healthy control (HC) subjects; a significant decrease was also noted for aMCI and Dementia groups compared to HC. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2021-08-28

    Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids

    ✓ Peer-reviewed Genetics Acta neuropathologica

    Key finding: Furthermore, APOE4 cerebral organoids have increased αSyn accumulation compared to those with APOE3. +1 more finding

    Full summary, score breakdown and related studies → Original source

  9. 2021-08-28

    Beyond Activation: Characterizing Microglial Functional Phenotypes

    ✓ Peer-reviewed Genetics Cells

    Key finding: Recent progress in single-cell deep sequencing methods allowed for more refined differentiation and revealed regional-, age- and sex-dependent differences of the microglial population, and a growing number of studies demonstrate various expression profiles defining microglial subpopulations.

    Full summary, score breakdown and related studies → Original source

  10. 2021-08-27

    Drug repurposing: small molecules against Cu(II)-amyloid-β and free radicals

    ✓ Peer-reviewed Drug development Journal of inorganic biochemistry

    Key finding: Increasing evidence reveals pathological connections among these distinct components in AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2021-08-27

    Molecular Mechanisms of Environmental Metal Neurotoxicity: A Focus on the Interactions of Metals with Synapse Structure and Function

    ✓ Peer-reviewed Risk factors Toxics

    Key finding: There is increasing evidence linking environmental exposure to metal contaminants to the etiology of neurological diseases in early life (e.g., autism spectrum disorder) or late life (e.g., Alzheimer's disease). +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2021-08-27

    Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy

    ✓ Peer-reviewed Disease mechanisms Molecular cell

    Key finding: These results reveal a complex containing oTau, HNRNPA2B1, and m 6 A that contributes to the integrated stress response of oTau.

    Full summary, score breakdown and related studies → Original source

  13. 2021-08-27

    Mindfulness Training Improves Cognition and Strengthens Intrinsic Connectivity Between the Hippocampus and Posteromedial Cortex in Healthy Older Adults

    ✓ Peer-reviewed Treatments Frontiers in aging neuroscience

    Key finding: In this randomized controlled trial, we examined the behavioral and neural outcomes following mindfulness training ( n = 72), compared to a cognitive fitness program ( n = 74) in healthy, cognitively normal, older adults (65-80 years old). +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2021-08-26

    caso de aducanumab ¿Más esperanza que ciencia?

    ✓ Peer-reviewed Treatments ARS MEDICA Revista de Ciencias Médicas

    Key finding: En junio, la Agencia de Alimentos y medicamentos de los Estados Unidos (FDA) otorgó aprobación mediante vía acelerada al medicamento aducanumab, desarrollado por Biogen, Inc. para tratamiento de la enfermedad de Alzheimer (EA). +2 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2021-08-26

    Implementation of Goals of Care Communication Innovation Among Nursing Homes: A Multiple Case Study Design

    ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association

    Key finding: High management support aligned with implementation effectiveness within NHs. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2021-08-26

    APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation

    ✓ Peer-reviewed Genetics Stem cell reports

    Key finding: Secretory factors in conditioned media from ApoE4 astrocytes significantly increased amyloid precursor protein (APP) levels and Aβ secretion in neurons.

    Full summary, score breakdown and related studies → Original source

  17. 2021-08-26

    Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic

    ✓ Peer-reviewed Inflammation and the immune system Cell

    Key finding: Here, we found that Grn -/- mice exhibit a global deficiency in bis(monoacylglycero)phosphate (BMP), an endolysosomal phospholipid we identified as a pH-dependent PGRN interactor as well as a redox-sensitive enhancer of lysosomal proteolysis and lipolysis. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →