Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 8,626–8,650 of 27,380 studies, newest first · page 346 of 1096.
August 2022 6
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2022-08-01
The Link between Obstructive Sleep Apnea and Neurocognitive Impairment: An Official American Thoracic Society Workshop Report
55/100 ✓ Peer-reviewed Disparities Annals of the American Thoracic Society
Key finding: An American Thoracic Society workshop was convened that included clinicians, basic scientists, and epidemiologists with expertise in OSA, cognition, and dementia, with the overall objectives of summarizing the state of knowledge in the field, identifying important research gaps, and identifying potential directions for future research. +1 more finding
Full summary, score breakdown and related studies → Original source
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2022-08-01
Worldwide prevalence of mild cognitive impairment among community dwellers aged 50 years and older: a meta-analysis and systematic review of epidemiology studies
80/100 ✓ Peer-reviewed Prevention and risk Age and ageing
Key finding: The global prevalence of MCI among community dwellers is over 15% and is affected by age, gender, education level and region of study sites. +3 more findings
Full summary, score breakdown and related studies → Original source
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2022-08-01
Use of Bacopa monnieri in the Treatment of Dementia Due to Alzheimer Disease: Systematic Review of Randomized Controlled Trials
43/100 ✓ Peer-reviewed Treatments Interactive journal of medical research
Key finding: Our comprehensive search yielded 5 eligible studies. +2 more findings
Full summary, score breakdown and related studies → Original source
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2022-08-01
Safety and Efficacy of Semorinemab in Individuals With Prodromal to Mild Alzheimer Disease: A Randomized Clinical Trial
78/100 ✓ Peer-reviewed Treatments JAMA neurology
Key finding: In participants with prodromal to mild AD in this randomized clinical trial, semorinemab did not slow clinical AD progression compared with placebo throughout the 73-week study period but did demonstrate an acceptable and well-tolerated safety profile. +2 more findings
Full summary, score breakdown and related studies → Original source
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2022-08-01
β-Amyloid-Dependent and -Independent Genetic Pathways Regulating CSF Tau Biomarkers in Alzheimer Disease
48/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: Genetic pathways implicated in causing AD are related to altered levels of soluble tau through both Aβ-dependent and Aβ-independent mechanisms, which may have relevance for anti-tau drug development. +2 more findings
Full summary, score breakdown and related studies → Original source
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2022-08-01
Detection of Brain Tau Pathology in Down Syndrome Using Plasma Biomarkers
64/100 ✓ Peer-reviewed Biomarkers JAMA neurology
Key finding: Among 300 participants with DS and a control group of 37 non-DS siblings, mean (SD) age was 45.0 (10.1) years, and 167 (49.6%) were men. +3 more findings
Full summary, score breakdown and related studies → Original source
July 2022 19
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2022-07-31
Comparative study of rivastigmine and galantamine on the transgenic Drosophila model of Alzheimer's disease
41/100 ✓ Peer-reviewed Treatments Current research in pharmacology and drug discovery
Key finding: Alzheimer's Disease (AD) is characterized as a progressive neurodegenerative disease most commonly associated with memory deficits and cognitive decline. +3 more findings
Full summary, score breakdown and related studies → Original source
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2022-07-31
The Alzheimer's Association appropriate use recommendations for blood biomarkers in Alzheimer's disease
60/100 ✓ Peer-reviewed Biomarkers Alzheimer s & Dementia
Blood-based markers (BBMs) have recently shown promise to revolutionize the diagnostic and prognostic work-up of Alzheimer's disease (AD), as well as to improve the design of interventional trials.
Full summary, score breakdown and related studies → Original source
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2022-07-30
The role of genetic risk factors of Alzheimer's disease in synaptic dysfunction
41/100 ✓ Peer-reviewed Disease mechanisms Seminars in cell & developmental biology
Key finding: While AD is a multifactorial disease, synaptic dysfunction is one of the major neuropathological changes that occur early in AD, before clinical symptoms appear, and is associated with the progression of cognitive deterioration. +1 more finding
Full summary, score breakdown and related studies → Original source
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2022-07-29
Clinical impact of whole-genome sequencing in patients with early-onset dementia
52/100 ✓ Peer-reviewed Genetics Journal of neurology, neurosurgery, and psychiatry
Key finding: Clinical genetic diagnosis was achieved in 7 of 50 (14%) of the patients, with a further 8 patients (16%) found to have established risk factors which may have contributed to their EOD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-07-29
Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis
49/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in immunology
Key finding: Accumulating evidence attests to the important roles of the immune system in OA pathogenesis. +3 more findings
Full summary, score breakdown and related studies → Original source
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2022-07-28
Impact of a multidomain lifestyle intervention on regional spontaneous brain activity
64/100 ✓ Peer-reviewed Prevention trials Frontiers in aging neuroscience
Key finding: ReHo values from regions with significant longitudinal changes were compared between the intervention and control groups and their correlations with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) or serum brain-derived neurotrophic factor (BDNF) were evaluated. +1 more finding
Full summary, score breakdown and related studies → Original source
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2022-07-28
Longitudinal associations of pain and cognitive decline in community-dwelling older adults
78/100 ✓ Peer-reviewed Prevention trials Psychology and aging
Key finding: Pain is inversely associated with cognitive function in older adults, but the effects of pain on cognitive decline are not fully clear.
Full summary, score breakdown and related studies → Original source
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2022-07-28
Association between the mediterranean diet and cognitive health among healthy adults: A systematic review and meta-analysis
76/100 ✓ Peer-reviewed Prevention trials Frontiers in nutrition
Key finding: Adherence to the MeDi diet may reduce the risk of MCI and AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-07-27
Evaluation of tau deposition using 18F-PI-2620 PET in MCI and early AD subjects-a MissionAD tau sub-study
52/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's research & therapy
Key finding: Percentage of visually tau-positive scans increased with amyloid-beta deposition measured in 18F-florbetaben Centiloids (CL) (7.7% (<36 CL), 80% (>83 CL)). 18F-PI-2620 standardized uptake value ratio (SUVR) was correlated with increased 18F-florbetaben CL in several regions of interest. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-07-27
Physical and Mental Activity, Disease Susceptibility, and Risk of Dementia: A Prospective Cohort Study Based on UK Biobank
62/100 ✓ Peer-reviewed Long-term cohort studies Neurology
Key finding: The association between patterns of physical/mental activity and dementia and how it is affected by disease susceptibility remains unknown. +3 more findings
Full summary, score breakdown and related studies → Original source
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2022-07-27
Association of Ultraprocessed Food Consumption With Risk of Dementia: A Prospective Cohort Study
70/100 ✓ Peer-reviewed Prevention and risk Neurology
Key finding: In this prospective cohort study, higher consumption of UPF was associated with higher risk of dementia, whereas substituting unprocessed or minimally processed foods for UPF was associated with lower risk of dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-07-26
Effect of simultaneous exercise and cognitive training on executive functions, baroreflex sensitivity, and pre-frontal cortex oxygenation in healthy older adults: a pilot study
76/100 ✓ Peer-reviewed Prevention trials GeroScience
Key finding: The superiority of simultaneous training compared to passive control and physical training alone seems clear but very few studies compared simultaneous training to cognitive training alone. +2 more findings
Full summary, score breakdown and related studies → Original source
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2022-07-25
Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer's disease
41/100 ✓ Peer-reviewed Genetics Neuron
Key finding: Tau aggregation in neurofibrillary tangles (NFTs) is closely associated with neurodegeneration and cognitive decline in Alzheimer's disease (AD). +1 more finding
Full summary, score breakdown and related studies → Original source
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2022-07-25
Investigation of coenzyme Q10 status, serum amyloid-β, and tau protein in patients with dementia
48/100 ✓ Peer-reviewed Biomarkers Frontiers in aging neuroscience
Key finding: A total of 73% of patients had a low coenzyme Q10 status. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-07-25
Lexical and Acoustic Speech Features Relating to Alzheimer Disease Pathology
55/100 ✓ Peer-reviewed Tau biomarkers Neurology
Key finding: We compared digital speech and language features of patients with amnestic Alzheimer disease (aAD) or logopenic variant primary progressive aphasia (lvPPA) in a biologically confirmed cohort and related these features to neuropsychiatric test scores and CSF analytes. +3 more findings
Full summary, score breakdown and related studies → Original source
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2022-07-24
Association of plasma biomarkers of amyloid and neurodegeneration with cerebrovascular disease and Alzheimer's disease
48/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging
Key finding: Higher plasma NfL and Aβ42/40 ratio were associated with cerebrovascular neuropathologic scales (p < 0.05) but not with Braak stage, neuritic plaque score, or Thal phase. +1 more finding
Full summary, score breakdown and related studies → Original source
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2022-07-22
A voice recognition-based digital cognitive screener for dementia detection in the community: Development and validation study
50/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in psychiatry
Key finding: A total of 103 participants completed all investigations and were included in the analysis. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-07-22
Global and regional projections of the economic burden of Alzheimer's disease and related dementias from 2019 to 2050: A value of statistical life approach
43/100 ✓ Peer-reviewed Disparities EClinicalMedicine
Key finding: In 2019, the global VSL-based economic burden of ADRDs was an estimated $2.8 trillion.
Full summary, score breakdown and related studies → Original source
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2022-07-22
TREM2 macrophages induced by human lipids drive inflammation in acne lesions
53/100 ✓ Peer-reviewed TREM2 and immune genetics Science immunology
Key finding: The disease involves excess production of lipids, particularly squalene, increased growth of Cutibacterium acnes , and a host inflammatory response with foamy macrophages. +3 more findings
Full summary, score breakdown and related studies → Original source
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