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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 9,501–9,525 of 27,380 studies, newest first · page 381 of 1096.

December 2021 25

  1. 2021-12-16

    Distributions of Aβ42 and Aβ42/40 in the Cerebrospinal Fluid in View of the Probability Theory

    ✓ Peer-reviewed Biomarkers Diagnostics (Basel, Switzerland)

    Key finding: Amyloid β 42/40 concentration quotient has been empirically shown to improve accuracy of the neurochemical diagnostics of Alzheimer's Disease (AD) compared to the Aβ42 concentration alone, but this improvement in diagnostic performance has not been backed up by a theoretical argumentation so far. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2021-12-16

    Diet and Dementia: A Prospective Study

    ✓ Peer-reviewed Prevention trials Nutrients

    Key finding: Whether dietary and nutrition and dietary patterns are associated with the development of dementia is an interesting research question. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2021-12-16

    Differential Effects by Mental Health Status of Filling the Medicare Part D Coverage Gap

    ✓ Peer-reviewed Health systems and care delivery Medical Care

    Key finding: Closing the gap substantially reduced individuals' out-of-pocket spending, and the reduction was larger for those with more severe mental disorders. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-12-16

    TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration

    ✓ Peer-reviewed TREM2 and immune genetics Nature neuroscience

    Key finding: However, the function of TREM2 in neurodegeneration is still not fully understood. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2021-12-16

    APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes

    ✓ Peer-reviewed Genetics Stem cell reports

    Key finding: Taken together, APOE4 iAstrocytes reveal a disease-relevant phenotype, causing dysregulated cholesterol/lipid homeostasis, increased inflammatory signaling, and reduced β-amyloid uptake, while APOE2 iAstrocytes show opposing effects.

    Full summary, score breakdown and related studies → Original source

  6. 2021-12-15

    Hearing loss and brain disorders: A review of multiple pathologies

    ✓ Peer-reviewed Risk factors Open medicine (Warsaw, Poland)

    Key finding: Several causative factors are associated with hearing loss (HL) and brain disorders. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2021-12-15

    Brain Imaging of the GLP-1 Receptor in Obesity Using 68Ga-NODAGA-Exendin-4 PET

    ✓ Peer-reviewed Drug development Brain sciences

    Key finding: Interestingly, preclinical and clinical studies further suggest that GLP-1 receptor agonists may decrease motor, behavioral, and cognitive symptoms in (animal models) Parkinson's disease and Alzheimer's disease and may slow down neurodegeneration. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2021-12-15

    Vessels Sing Their ARIAs: The Role of Vascular Amyloid in the Age of Aducanumab

    ✓ Peer-reviewed Drug development Stroke

    Key finding: In clinical trials, amyloid-β immunotherapy has been associated with a high rate of amyloid-related imaging abnormalities, potentially driven by coexisting cerebral amyloid angiopathy. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2021-12-15

    Associations of plasma neurofilament light chain and progranulin with frailty in older adults

    ✓ Peer-reviewed Biomarkers Journal of the American Geriatrics Society

    Key finding: This study failed to find associations of circulating NfL and PGRN levels with frailty among community-dwelling older adults in adjusted analyses. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2021-12-14

    Mitigating site effects in covariance for machine learning in neuroimaging data

    ✓ Peer-reviewed Digital health tools Human brain mapping

    Key finding: This stems from the fact that such methods fail to address how correlations between measurements can vary across sites. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2021-12-14

    Comparison of plasma neurofilament light and total tau as neurodegeneration markers: associations with cognitive and neuroimaging outcomes

    ✓ Peer-reviewed Long-term cohort studies Alzheimer's research & therapy

    Key finding: Total tau protein (T-Tau) and neurofilament light chain (NfL) have emerged as candidate plasma biomarkers of neurodegeneration, but studies have not compared how these biomarkers cross-sectionally or longitudinally associate with cognitive and neuroimaging measures. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2021-12-14

    Association of Cognitive Impairment With Free Water in the Nucleus Basalis of Meynert and Locus Coeruleus to Transentorhinal Cortex Tract

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: They also suggest that FW elevation occurs in the locus coeruleus to transentorhinal cortex tract, nucleus basalis of Meynert, and hippocampus in the transition from CN to EMCI, while other basal forebrain regions and the entorhinal cortex are not affected until a later stage of AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2021-12-14

    Validation of Plasma Amyloid-β 42/40 for Detecting Alzheimer Disease Amyloid Plaques

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: Plasma Aβ42/Aβ40 is a robust measure for detecting amyloid plaques and can be utilized to aid in the diagnosis of AD, identify those at risk for future dementia due to AD, and improve the diversity of populations enrolled in AD research and clinical trials. +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2021-12-13

    Cohort Profile: The Longitudinal Ageing Study in India (LASI)

    ✓ Peer-reviewed Costs and economics International Journal of Epidemiology

    Key finding: LASI is India’s first ageing study and the world’s largest in terms of sample size, and will provide comprehensive longitudinal data for designing policies and programmes targeted toward the overall well-being of the older population. +2 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2021-12-13

    Social isolation, social support and loneliness as predictors of cardiovascular disease incidence and mortality

    ✓ Peer-reviewed Risk factors BMC geriatrics

    Key finding: Individuals with poor social health were 42 % more likely to develop CVD (p = 0.01) and twice as likely to die from CVD (p = 0.02) over a median 4.5 years follow-up. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2021-12-13

    Prevalence of Oropharyngeal Dysphagia and Risk of Pneumonia, Malnutrition, and Mortality in Adults Aged 60 Years and Older: A Meta-Analysis

    ✓ Peer-reviewed Clinical safety Gerontology

    Key finding: Early identification and management of OD should consider geriatric syndromes and neurogenic comorbidities to prevent malnutrition and pneumonia and reduce mortality in adults aged 60 years and older. +2 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2021-12-13

    Prediction of Postoperative Delirium in Geriatric Hip Fracture Patients: A Clinical Prediction Model Using Machine Learning Algorithms

    ✓ Peer-reviewed Digital health tools Geriatric orthopaedic surgery & rehabilitation

    Key finding: The clinical prediction model can play a beneficial role in decision-making for preventative measures for patients at risk of developing a delirium. +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2021-12-12

    A polygenic risk score predicts mosaic loss of chromosome Y in circulating blood cells

    ✓ Peer-reviewed Genetics Cell & bioscience

    Key finding: We calculated a PRS for LOY in 5131 men aged 70 years and older. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2021-12-12

    Comparison of rates of dementia among older adult recipients of two, one, or no vaccinations

    ✓ Peer-reviewed Digital health tools Journal of the American Geriatrics Society

    Key finding: Receiving two types of vaccinations versus one type was associated with lower dementia risk. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2021-12-11

    Glucagon-like peptide-1 analogs mitigate neuroinflammation in Alzheimer's disease by suppressing NLRP2 activation in astrocytes

    ✓ Peer-reviewed Drug development Molecular and cellular endocrinology

    Key finding: We found that 5 × FAD transgenic mice treated with the synthetic GLP-1 receptor agonist exenatide had improved cognitive function per the Morris water maze test. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2021-12-10

    Mitophagy in aging and longevity

    ✓ Peer-reviewed Disease mechanisms IUBMB life

    Key finding: Defects in mitophagy are associated with Parkinson's, Alzheimer's disease, cancer, and other degenerative disorders.

    Full summary, score breakdown and related studies → Original source

  22. 2021-12-10

    Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia

    ✓ Peer-reviewed Biomarkers Translational neurodegeneration

    Key finding: Unlike pNfL, which was increased similarly in both clinical groups, pGFAP was increased in FTD but lower than in AD (all P < 0.01). +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2021-12-09

    Contribution of socioeconomic, lifestyle, and medical risk factors to disparities in dementia and mortality

    ✓ Peer-reviewed Disparities SSM - population health

    Key finding: Taken together, work demonstrates the potential benefit of taking an intersectional approach to understanding disparities in dementia.

    Full summary, score breakdown and related studies → Original source

  24. 2021-12-09

    Risk of Alzheimer's disease and related dementia by sex and race/ethnicity: The Multiethnic Cohort Study

    ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: The ASDIR for ADRD was higher for women (17.0 per 1000 person-years) than for men (15.3) and varied across African Americans (22.9 in women, 21.5 in men), Native Hawaiians (19.3, 19.4), Latinos (16.8, 14.7), Whites (16.4, 15.5), Japanese Americans (14.8, 13.8), and Filipinos (12.5, 9.7). +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2021-12-08

    The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals

    ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Carrying at least one ε2 allele was associated with larger GM volumes in brain areas typically affected by AD and also in areas associated with cognitive resilience. +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →