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[Retinal Imaging as Potential Biomarkers for Dementia]
Mariko Sasaki. Brain and nerve = Shinkei kenkyu no shinpo, 2021-11
Topic: Plasma and spinal-fluid biomarkers
Alzheimer's disease (AD) is a leading cause of dementia, and the current diagnostic methods of AD, such as positron emission tomography imaging, have a high cost and poor accessibility. Amyloidβ accumulates in the brain long before the symptomatic onset of AD, and can also be found in the inner retina. Anatomically and developmentally, the retina is an extension of the brain, and is the only part of the central nervous system that can be imaged non-invasively. Therefore, retinal imaging has potential as a potential biomarker for dementia. Previous studies have demonstrated that inner retinal thinning (measured using optical coherence tomography [OCT]) is associated with an increased risk of dementia, including AD. In addition, retinal vascular changes assessed using fundus photographs and OCT angiography were associated with dementia. We propose that artificial intelligence algorithms could be applied to process these retinal images and contribute to the automated interpretation of retinal images and screening for dementia. In addition, amyloidβ in the retina has been identified using hyperspectral imaging, a non-invasive retinal imaging, as a surrogate marker of brain amyloidβ. Retinal imaging may provide a novel biomarker and contribute to screening individuals at risk of dementia, monitoring disease progression, and assessing therapeutic efficacy.
Key findings
- Previous studies have demonstrated that inner retinal thinning (measured using optical coherence tomography [OCT]) is associated with an increased risk of dementia, including AD.
- In addition, retinal vascular changes assessed using fundus photographs and OCT angiography were associated with dementia.
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 23 of the 56 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Brain and nerve = Shinkei kenkyu no shinpo) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 34759057) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 23 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 23 of the 56 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Sasaki, M. (2021). [Retinal Imaging as Potential Biomarkers for Dementia]. Brain and nerve = Shinkei kenkyu no shinpo. https://doi.org/10.11477/mf.1416201919
Vancouver
Sasaki M. [Retinal Imaging as Potential Biomarkers for Dementia]. Brain and nerve = Shinkei kenkyu no shinpo. 2021. doi:10.11477/mf.1416201919. PMID: 34759057.
BibTeX
@article{sasaki2021-34759057,
author = {Sasaki, Mariko},
title = {{[Retinal Imaging as Potential Biomarkers for Dementia]}},
journal = {Brain and nerve = Shinkei kenkyu no shinpo},
year = {2021},
doi = {10.11477/mf.1416201919},
pmid = {34759057},
url = {https://doi.org/10.11477/mf.1416201919}
}
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