Newest studies

Sanfilippo syndrome: a mini-review

45/100 ✓ Peer-reviewed Getting a diagnosis Journal of inherited metabolic disease

Key finding: In the first phase, which usually starts between 1 and 4 years of age, a developmental delay becomes apparent after an initial normal development during the first 1-2 years of life. +4 more findings

Full summary, score breakdown and related studies → Original source

Efficacy of Music Therapy in the Treatment of Behavioral and Psychiatric Symptoms of Dementia

43/100 ✓ Peer-reviewed Clinical safety Alzheimer Disease & Associated Disorders

Key finding: NPI total score significantly decreased in the experimental group at 8th, 16th, and 20th weeks (interaction time x group: F3,165=5.06, P=0.002). +3 more findings

• Treatments

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Dementia and Medicare at life's end

48/100 ✓ Peer-reviewed Costs and economics Health services research

Key finding: On average, ADRD diagnosis was not significantly associated with excess Medicare payments over the last 5 years of life. +4 more findings

• Policy

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Person-centred care of people with severe Alzheimer's disease: current status and ways forward

40/100 ✓ Peer-reviewed End-of-life care The Lancet. Neurology

Key finding: When caring for people with severe Alzheimer's disease (AD), the concept of the person being central is increasingly advocated in clinical practice and academia as an approach to deliver high-quality care. +4 more findings

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Metals in Alzheimer's and Parkinson's diseases

36/100 ✓ Peer-reviewed Disease mechanisms Current opinion in chemical biology

Key finding: There has been steadily growing interest in the participation of metal ions (especially, zinc, copper, and iron) in neurobiological processes, such as the regulation of synaptic transmission. +4 more findings

• Other Dementias

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Structural insights into aberrant topological patterns of large-scale cortical networks in Alzheimer's disease

36/100 ✓ Peer-reviewed Brain scans and imaging The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Recent research on Alzheimer's disease (AD) has shown that cognitive and memory decline in this disease is accompanied by disrupted changes in the coordination of large-scale brain functional networks. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Biochemistry of Tau in Alzheimer's disease and related neurological disorders

36/100 ✓ Peer-reviewed Genetics Expert review of proteomics

Key finding: Microtubule-associated Tau proteins belong to a family of factors that polymerize tubulin dimers and stabilize microtubules. +4 more findings

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Intrauterine growth restriction affects the preterm infant's hippocampus

36/100 ✓ Peer-reviewed Hippocampus size on brain scans Pediatric research

Key finding: The effect of IUGR in preterm infants on the hippocampus was studied using 3D magnetic resonance imaging at term-equivalent age Thirteen preterm infants born with IUGR after placental insufficiency were compared with 13 infants with normal intrauterine growth age matched for gestational age. +3 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Comparison of 2 interventions for liquid aspiration on pneumonia incidence: a randomized trial

57/100 ✓ Peer-reviewed Clinical safety Annals of internal medicine

Key finding: No definitive conclusions about the superiority of any of the tested interventions can be made. +2 more findings

• Clinical Trials
• Risk Factors

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Refining frontotemporal dementia with parkinsonism linked to chromosome 17: introducing FTDP-17 (MAPT) and FTDP-17 (PGRN)

36/100 ✓ Peer-reviewed Disease mechanisms Archives of neurology

Key finding: Our findings describe an intriguing oddity of nature in which 2 genes can cause a similar phenotype through apparently different mechanisms yet reside so near to each other on the same chromosome.

• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

Pathologic findings in prospectively ascertained essential tremor subjects

40/100 ✓ Peer-reviewed Disease mechanisms Neurology

Key finding: This study supports previous findings of heterogenous pathology in essential tremor (ET). +2 more findings

• Brain Biology

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Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease

48/100 ✓ Peer-reviewed Brain tissue and pathology Brain pathology (Zurich, Switzerland)

Key finding: One major characteristic of its pathology is accumulation of amyloid-beta (Abeta) as insoluble deposits in brain parenchyma and in blood vessel walls [cerebral amyloid angiopathy (CAA)]. +3 more findings

• Brain Biology

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Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease

46/100 ✓ Peer-reviewed Risk genes beyond APOE Archives of neurology

Key finding: A majority of mutations within the beta-amyloid region of the amyloid precursor protein (APP) gene cause inherited forms of intracerebral hemorrhage. +3 more findings

• Genetics
• Brain Biology
• Digital Tools

Full summary, score breakdown and related studies → Original source

Genetic aspects of Alzheimer disease

45/100 ✓ Peer-reviewed Risk genes beyond APOE Genetics in medicine : official journal of the American College of Medical Genetics

Key finding: The neuropathologic findings of amyloid-beta plaques and tau containing neurofibrillary tangles represent important molecular clues to the underlying pathogenesis. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Personal mastery is associated with reduced sympathetic arousal in stressed Alzheimer caregivers

45/100 ✓ Peer-reviewed Digital health tools The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: Caregivers with higher mastery had less NE reactivity to the stressor task. +1 more finding

• Caregiving

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Cognitive impairment in the aging dialysis and chronic kidney disease populations: an occult burden

46/100 ✓ Peer-reviewed Caregiving Advances in chronic kidney disease

Key finding: Severe cognitive impairment or dementia among hemodialysis patients is associated with an approximately 2-fold increased risk of both mortality and dialysis withdrawal. +1 more finding

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History of depression, depressive symptoms, and medial temporal lobe atrophy and the risk of Alzheimer disease

57/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: This risk was not mediated by smaller hippocampal or amygdalar volumes. +1 more finding

• Risk Factors

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Frequency and course of mild cognitive impairment in a multiethnic community

62/100 ✓ Peer-reviewed Getting a diagnosis Annals of neurology

Key finding: Impaired memory and language were useful predictors of transition to AD. +1 more finding

• Early Stage

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Parkinson's disease: clinical features and diagnosis

54/100 ✓ Peer-reviewed Getting a diagnosis Journal of neurology, neurosurgery, and psychiatry

Key finding: A thorough understanding of the broad spectrum of clinical manifestations of PD is essential to the proper diagnosis of the disease.

• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

A randomized trial of the impact of a specific care plan in 1120 Alzheimer's patients (PLASA Study) over a two-year period: design and baseline data

56/100 ✓ Peer-reviewed Treatments The journal of nutrition, health & aging

Key finding: Persons with dementia suffer different losses at different stages of the disease and therefore accurate assessment of abilities and losses is critical to assist the person in planning for their future and for care needs.

• Clinical Trials

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Apolipoprotein E, amyloid-beta, and blood-brain barrier permeability in Alzheimer disease

39/100 ✓ Peer-reviewed Genetics Journal of neuropathology and experimental neurology

Key finding: This review investigates the relationships between apoE, Abeta, and the BBB in AD. +4 more findings

• Genetics
• Brain Biology

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CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases

52/100 ✓ Peer-reviewed Genetics American journal of clinical pathology

Key finding: In contrast, there is no validated CSF biomarker for PD. +4 more findings

• Biomarkers
• Other Dementias

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Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

51/100 ✓ Peer-reviewed Lewy body dementia The Journal of cell biology

Key finding: These results demonstrate that PGRN/GRN is a neurotrophic factor with activities that may be involved in the development of the nervous system and in neurodegeneration.

• Other Dementias
• Genetics

Full summary, score breakdown and related studies → Original source

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

57/100 ✓ Peer-reviewed Risk genes beyond APOE Nature Genetics

Key finding: We report eight missense mutations in nine individuals--six from individuals with sporadic ALS (SALS) and three from those with familial ALS (FALS)--and a concurring increase of a smaller TDP-43 product. +1 more finding

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid

36/100 ✓ Peer-reviewed Drug development European journal of pharmacology

Key finding: Effects of both native GLP-1 and (Val8)GLP-1 on synaptic plasticity (LTP) in the hippocampus (15 nmol i.c.v.) were examined and results demonstrated for the first time that both peptides have enhancing effects on LTP. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source