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62/100

✓ Peer-reviewed alzhub usefulness score 62 out of 100. Brain tissue and pathology

Topic: Amyloid, tau and blood-test diagnosis

The key pathological hallmarks-extracellular plaques and intracellular neurofibrillary tangles (NFT)-described by Alois Alzheimer in his seminal 1907 article are still central to the postmortem diagnosis of Alzheimer's disease (AD), but major advances in our understanding of the underlying pathophysiology as well as significant progress in clinical diagnosis and therapy have changed the perspective and importance of neuropathologic evaluation of the brain. The notion that the pathological processes underlying AD already start decades before symptoms are apparent in patients has brought a major change reflected in the current neuropathological classification of AD neuropathological changes (ADNC). The predictable progression of beta-amyloid (Aβ) plaque pathology from neocortex, over limbic structures, diencephalon, and basal ganglia, to brainstem and cerebellum is captured in phases descr

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Trejo-Lopez, J. A., Yachnis, A. T., & Prokop, S. (2022). Neuropathology of Alzheimer's Disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. https://doi.org/10.1007/s13311-021-01146-y

Vancouver

Trejo-Lopez JA, Yachnis AT, Prokop S. Neuropathology of Alzheimer's Disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022. doi:10.1007/s13311-021-01146-y. PMID: 34729690.

BibTeX

@article{trejolopez2022-34729690,
  author  = {Trejo-Lopez, J. A. and Yachnis, A. T. and Prokop, S.},
  title   = {{Neuropathology of Alzheimer's Disease}},
  journal = {Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics},
  year    = {2022},
  doi     = {10.1007/s13311-021-01146-y},
  pmid    = {34729690},
  url     = {https://doi.org/10.1007/s13311-021-01146-y}
}

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Key findings

The notion that the pathological processes underlying AD already start decades before symptoms are apparent in patients has brought a major change reflected in the current neuropathological classification of AD neuropathological changes (ADNC).
The predictable progression of beta-amyloid (Aβ) plaque pathology from neocortex, over limbic structures, diencephalon, and basal ganglia, to brainstem and cerebellum is captured in phases described by Thal and colleagues.
The progression of NFT pathology from the transentorhinal region to the limbic system and ultimately the neocortex is described in stages proposed by Braak and colleagues.
The density of neuritic plaque pathology is determined by criteria defined by the Consortium to establish a registry for Alzheimer's diseases (CERAD).

Why it matters

This review describes the hallmark plaques and tangles of Alzheimer's disease and notes that the pathological processes underlying the disease start decades before symptoms appear. It is a descriptive neuropathology review and does not report any treatment, cure, or prevention for Alzheimer's disease.

Study details

Study designcohort study
Evidence strengthModerate

How this study scored 62/100

Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics)
Journal's citation record	2 / 4	Neurotherapeutics: journal h-index 156 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	3 / 5	2022 — within 6 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	6 / 7	Cited 376 times (OpenAlex, 2026-10-10)
Citations per year	5 / 5	62.7 citations a year over 6 year(s) since 2022
Impact for its field and year	5 / 6	Cited 22.8× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	3 / 6	Cited by 12 other studies in this library
Still being cited	4 / 4	Cited 300 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Stefan Prokop: h-index 31 (OpenAlex, whole career)
Institution's track record	2 / 3	Mayo Clinic: institution h-index 1,606 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 34729690)
Free to read	0 / 2	Behind a paywall — scores zero
Total	62 / 100	—

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