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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 9,576–9,600 of 27,380 studies, newest first · page 384 of 1096.

November 2021 25

  1. 2021-11-29

    Plasma amyloid-β ratios in autosomal dominant Alzheimer's disease: the influence of genotype

    ✓ Peer-reviewed Biomarkers Brain : a journal of neurology

    Key finding: Age- and sex-adjusted models showed marked differences in plasma amyloid-β between genotypes: higher Aβ42:38 in PSEN1 versus APP (P < 0.001) and non-carriers (P < 0.001); higher Aβ38:40 in APP versus PSEN1 (P < 0.001) and non-carriers (P < 0.001); while Aβ42:40 was higher in both mutation groups compared to non-carriers (both P < 0.001). +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2021-11-29

    Characterization of pre-analytical sample handling effects on a panel of Alzheimer's disease-related blood-based biomarkers: Results from the Standardization of Alzheimer's Blood Biomarkers (SABB) working group

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: We constructed a standardized operating procedure for plasma handling, to facilitate introduction of blood-based biomarkers into the research and clinical settings. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2021-11-29

    Self-efficacy in controlling upsetting thoughts, but not positive gains, mediates the effects of benefit-finding group intervention for Alzheimer family caregivers

    ✓ Peer-reviewed Treatments Psychology and aging

    Key finding: Using mixed-effects regression, we demonstrated that benefit-finding increased caregivers' PAC and SE-CUT, but that only SE-CUT uniquely predicted depressive symptoms and global burden longitudinally. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2021-11-27

    Depressive symptom profiles predict dementia onset and brain pathology in older persons. The AGES-Reykjavik study

    ✓ Peer-reviewed Risk factors Neurobiology of aging

    Key finding: Cox regression analyses showed that severe LLD, mild LLD and apathy increased risk of dementia up to 12 years, compared to no LLD.

    Full summary, score breakdown and related studies → Original source

  5. 2021-11-26

    An App-Based Mindfulness-Based Self-compassion Program to Support Caregivers of People With Dementia: Participatory Feasibility Study

    ✓ Peer-reviewed Cognitive tests and assessment JMIR aging

    Key finding: Although there were no significant changes in caregiver burden, we were encouraged by the increased emotional well-being of our participants following the completion of our program. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2021-11-26

    Cognitive Intra-individual Variability in HIV: an Integrative Review

    ✓ Peer-reviewed Prevention trials Neuropsychology review

    Key finding: Cognitive intraindividual variability is associated with cognitive impairment and cognitive decline in various clinical populations. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2021-11-26

    Quantitative Brain Positron Emission Tomography in Female 5XFAD Alzheimer Mice: Pathological Features and Sex-Specific Alterations

    ✓ Peer-reviewed Biomarkers Frontiers in medicine

    Key finding: We could demonstrate that female 5XFAD mice showed a significant reduction in brain glucose metabolism and increased cerebral amyloid deposition compared with wild type animals, in accordance with the pathology seen in AD patients. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2021-11-25

    Late-Life Depression, Cognitive Impairment, and Relationship with Alzheimer's Disease

    ✓ Peer-reviewed Risk factors Dementia and geriatric cognitive disorders

    Key finding: These findings support the claim that the relationship between DS (or LLD) and the cognitive decline encountered in AD can be of 2 types: (1) risk factor or (2) prodrome.

    Full summary, score breakdown and related studies → Original source

  9. 2021-11-24

    Synergistic insights into human health from aptamer- and antibody-based proteomic profiling

    ✓ Peer-reviewed Genetics Nature Communications

    Key finding: We create a genetically anchored cross-platform proteome-phenome network comprising 547 protein–phenotype connections, 36.3% of which were only seen with one of the two platforms suggesting that both techniques capture distinct aspects of protein biology. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2021-11-24

    Blood-based biomarkers for Alzheimer's disease: towards clinical implementation

    ✓ Peer-reviewed Biomarkers The Lancet. Neurology

    Key finding: For many years, blood-based biomarkers for Alzheimer's disease seemed unattainable, but recent results have shown that they could become a reality.

    Full summary, score breakdown and related studies → Original source

  11. 2021-11-23

    4D flow MRI hemodynamic biomarkers for cerebrovascular diseases

    ✓ Peer-reviewed Vascular contributions Journal of internal medicine

    Key finding: The information that can be obtained from one single 4D flow MRI scan allows both the investigation of aberrant flow patterns at a focal location in the vasculature as well as estimations of brain-wide disturbances in blood flow. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2021-11-23

    Altered cell and RNA isoform diversity in aging Down syndrome brains

    ✓ Peer-reviewed Genetics Proceedings of the National Academy of Sciences of the United States of America

    Key finding: In DS, the ratio of inhibitory-to-excitatory neurons was significantly increased, which was not observed in previous reports examining sporadic AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2021-11-23

    Recent advances in molecular pathways and therapeutic implications targeting neuroinflammation for Alzheimer's disease

    ✓ Peer-reviewed Inflammation and the immune system Inflammopharmacology

    Key finding: Many evidences suggest the involvement of neuroinflammation in the pathology of AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2021-11-23

    Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal-derived extracellular vesicles

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: The alteration of the insulin-signaling/mTOR pathways represents an early event in DS brain and likely contributes to the cerebral dysfunction and intellectual disability observed in this unique population.

    Full summary, score breakdown and related studies → Original source

  15. 2021-11-23

    The probabilistic model of Alzheimer disease: the amyloid hypothesis revised

    ✓ Peer-reviewed Genetics Nature reviews. Neuroscience

    Key finding: This model fits autosomal dominant AD but is less applicable to sporadic AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2021-11-22

    Is Aducanumab for LMICs? Promises and Challenges

    ✓ Peer-reviewed Treatments Brain Sciences

    Key finding: A substantial proportion of patients with Alzheimer’s disease live in low- and middle-income countries (LMICs), and the debilitating effects of this disease exerts burdens on patients and caregivers in addition to the significant economic strains many nations bear. +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2021-11-22

    Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review

    ✓ Peer-reviewed Disease mechanisms Frontiers in molecular neuroscience

    Key finding: Hippocampal synaptic dysfunction is widely accepted to underlie the cognitive decline observed in some neurodegenerative disorders including Alzheimer's disease. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2021-11-22

    A Paradox in Digital Memory Assessment: Increased Sensitivity With Reduced Difficulty

    ✓ Peer-reviewed Cognitive tests and assessment Frontiers in digital health

    Key finding: However, recent studies suggest that OCL sensitivity to memory impairment in symptomatic AD is not as strong as that for other standardized assessments of memory. +2 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2021-11-22

    Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: Recent studies have demonstrated that enlarged PVS (ePVS) may have clinical consequences related to cognition.

    Full summary, score breakdown and related studies → Original source

  20. 2021-11-20

    Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core

    ✓ Peer-reviewed Brain scans and imaging Bioorganic & medicinal chemistry

    Key finding: The extent of Tau neurofibrillary tangles across defined brain regions corresponds well to the observed level of cognitive decline in AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2021-11-20

    Inflammatory markers in type 2 diabetes with vs. without cognitive impairment; a systematic review and meta-analysis

    ✓ Peer-reviewed Disease mechanisms Brain, behavior, and immunity

    Key finding: People with type 2 diabetes mellitus (T2DM) are at increased risk of mild cognitive impairment and dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2021-11-20

    Impact of the COVID-19 pandemic on emergency department attendances and acute medical admissions

    ✓ Peer-reviewed Disparities BMC emergency medicine

    Key finding: Reduced ED attendances in the first wave of the pandemic suggest opportunities for reducing low severity presentations to ED in the future, but also raise the possibility of harm from delayed or missed care. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2021-11-19

    The Interplay of the Unfolded Protein Response in Neurodegenerative Diseases: A Therapeutic Role of Curcumin

    ✓ Peer-reviewed Disease mechanisms Frontiers in aging neuroscience

    Key finding: The studies suggest that deregulation of proteostasis, particularly aberrant unfolded protein response (UPR) signaling, may be a common morbific process in the development of neurodegeneration. +1 more finding

    Full summary, score breakdown and related studies → Original source

  24. 2021-11-19

    α-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox

    ✓ Peer-reviewed Brain tissue and pathology Cell & bioscience

    Key finding: This epiphenomenon is nebulous, however, by lingering uncertainty over the quasi "pathogenic" behavior of α-synuclein conformers in DLB pathobiology. +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2021-11-19

    Associations between Brain Reserve Proxies and Clinical Progression in Alzheimer's Disease Dementia

    ✓ Peer-reviewed Risk factors International journal of environmental research and public health

    Key finding: The purpose of this study was to investigate whether brain and cognitive reserves were associated with the clinical progression of AD dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →