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Associations between Brain Reserve Proxies and Clinical Progression in Alzheimer's Disease Dementia
Hyung-Jun Yoon, Seung-Gon Kim, Sang Hoon Kim, Jong Inn Woo, Eun Hyun Seo, For The Alzheimer's Disease Neuroimaing Initiative. International journal of environmental research and public health, 2021-11-19
Topic: Brain imaging, connectivity and assessment
The purpose of this study was to investigate whether brain and cognitive reserves were associated with the clinical progression of AD dementia. We included participants with AD dementia from the Alzheimer's Disease Neuroimaging Initiative, provided they were followed up at least once, and candidate proxies for cognitive (education for early-life reserve and Adult Reading Test for late-life reserve) or brain reserve (intracranial volume [ICV] for early-life reserve and the composite value of [18F] fluorodeoxyglucose positron emission tomography regions of interest (FDG-ROIs) for late-life reserve) were available. The final analysis included 120 participants. Cox proportional hazards model revealed that FDG-ROIs were the only significant predictor of clinical progression. Subgroup analysis revealed a significant association between FDG-ROIs and clinical progression only in the larger ICV group (HR = 0.388, p = 0.028, 95% CI 0.167-0.902). Our preliminary findings suggest that relatively preserved cerebral glucose metabolism might delay further clinical progression in AD dementia, particularly in the greater ICV group. In addition to ICV, cerebral glucose metabolism could play an important role as a late-life brain reserve in the process of neurodegeneration. Distinguishing between early- and late-life reserves, and considering both proxies simultaneously, would provide a wider range of factors associated with the prognosis of AD dementia.
Key findings
- The purpose of this study was to investigate whether brain and cognitive reserves were associated with the clinical progression of AD dementia.
- Cox proportional hazards model revealed that FDG-ROIs were the only significant predictor of clinical progression.
- Subgroup analysis revealed a significant association between FDG-ROIs and clinical progression only in the larger ICV group (HR = 0.388, p = 0.028, 95% CI 0.167-0.902).
- Our preliminary findings suggest that relatively preserved cerebral glucose metabolism might delay further clinical progression in AD dementia, particularly in the greater ICV group.
- Distinguishing between early- and late-life reserves, and considering both proxies simultaneously, would provide a wider range of factors associated with the prognosis of AD dementia.
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Study details
- Participants120
- Effect sizeHR = 0.388
- Evidence strengthLow
How this study scored 55/100
Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 31 of the 56 points we could judge it on, which is 55 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (International journal of environmental research and public health) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 120 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 34831913) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 31 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 31 of the 56 points we could judge it on is 55 out of 100. |
| Total | 55 / 100 | — |
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APA 7th
Yoon, H.-J., Kim, S.-G., Kim, S. H., Woo, J. I., Seo, E. H., & Alzheimer's Disease Neuroimaing Initiative. (2021). Associations between Brain Reserve Proxies and Clinical Progression in Alzheimer's Disease Dementia. International journal of environmental research and public health. https://doi.org/10.3390/ijerph182212159
Vancouver
Yoon H.-J, Kim S.-G, Kim SH, Woo JI, Seo EH, Alzheimer's Disease Neuroimaing Initiative. Associations between Brain Reserve Proxies and Clinical Progression in Alzheimer's Disease Dementia. International journal of environmental research and public health. 2021. doi:10.3390/ijerph182212159. PMID: 34831913.
BibTeX
@article{yoon2021-34831913,
author = {Yoon, Hyung-Jun and Kim, Seung-Gon and Kim, Sang Hoon and Woo, Jong Inn and Seo, Eun Hyun and {Alzheimer's Disease Neuroimaing Initiative}},
title = {{Associations between Brain Reserve Proxies and Clinical Progression in Alzheimer's Disease Dementia}},
journal = {International journal of environmental research and public health},
year = {2021},
doi = {10.3390/ijerph182212159},
pmid = {34831913},
url = {https://doi.org/10.3390/ijerph182212159}
}