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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 8,326–8,350 of 27,380 studies, newest first · page 334 of 1096.

November 2022 16

  1. 2022-11-02

    Plasma Phosphorylated Tau at Threonine 181 and Neuropsychiatric Symptoms in Preclinical and Prodromal Alzheimer Disease

    ✓ Peer-reviewed Tau biomarkers Neurology

    Key finding: Plasma phosphorylated tau at threonine 181 (p-tau181), a well-validated marker of Alzheimer disease (AD) pathologic change, could be a more efficient way to diagnose AD than invasive or expensive biomarkers requiring CSF or PET. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2022-11-02

    Amyloid-Related Imaging Abnormalities: An Update

    ✓ Peer-reviewed Brain scans and imaging AJR. American journal of roentgenology

    Key finding: ARIA is often asymptomatic and self-resolving. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2022-11-01

    PSEN2 Thr421Met Mutation in a Patient with Early Onset Alzheimer's Disease

    ✓ Peer-reviewed Risk genes beyond APOE International journal of molecular sciences

    Key finding: Magnetic resonance imaging (MRI) images of the Korean patient revealed asymmetric atrophies in both temporo-parietal lobes. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2022-11-01

    TREM2 and Microglia Contribute to the Synaptic Plasticity: from Physiology to Pathology

    ✓ Peer-reviewed TREM2 and immune genetics Molecular neurobiology

    Key finding: In this review, we summarize the main characteristics of synapses and synaptic plasticity under physiological and pathological conditions. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2022-11-01

    Triggering receptor expressed on myeloid cells 2 deficiency exacerbates injury-induced inflammation in a mouse model of tauopathy

    ✓ Peer-reviewed TREM2 and immune genetics Frontiers in immunology

    Key finding: However, to our surprise, hTau;Trem2-/- mice exposed to TBI augments macrophage accumulation in the corpus callosum and white matter near the site of tissue damage in a chronic phase, which results in exacerbated axonal injury, tau aggregation, and impaired neurogenesis. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2022-11-01

    Distinguishing Frontotemporal Lobar Degeneration Tau From TDP-43 Using Plasma Biomarkers

    ✓ Peer-reviewed Biomarkers JAMA neurology

    Key finding: Of 349 participants with available plasma data, 234 met inclusion criteria (31 controls, 141 in the training sample, and 62 in the validation sample). +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2022-11-01

    Emerging blood exosome-based biomarkers for preclinical and clinical Alzheimer's disease: a meta-analysis and systematic review

    ✓ Peer-reviewed Biomarkers Neural regeneration research

    Key finding: The meta-analysis results showed that core biomarkers including Aβ 1-42 , P-T181-tau, P-S396-tau, and T-tau were increased in blood neuron-derived exosomes of preclinical Alzheimer's disease, mild cognitive impairment, and Alzheimer's disease patients. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2022-11-01

    Development and External Validation of a Mortality Prediction Model for Community-Dwelling Older Adults With Dementia

    ✓ Peer-reviewed End-of-life care JAMA internal medicine

    Key finding: Of 4267 participants with probable dementia in HRS, the mean (SD) age was 82.2 (7.6) years, 2930 (survey-weighted 69.4%) were female, and 785 (survey-weighted 12.1%) identified as Black.

    Full summary, score breakdown and related studies → Original source

  9. 2022-11-01

    ASSOCIATION BETWEEN VIOLENT CRIME INCIDENT PROXIMITY AND COGNITIVE FUNCTION IN OLDER AFRICAN AMERICANS

    ✓ Peer-reviewed Risk factors Innovation in Aging

    Key finding: Research on Area Deprivation Index (ADI) suggests that the built environment and neighborhood stressors (e.g., violent crime incidents) play a role in later-life cognitive function. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2022-11-01

    PROFILE OF DECEDENTS FROM A NATIONAL COHORT OF ASSISTED LIVING RESIDENTS

    ✓ Peer-reviewed Health systems and care delivery Innovation in Aging

    Key finding: An increasing number of older adults reside in assisted living (AL) toward the end of life, and it remains unclear if this trend represents an additional place of care and end-of-life transition before eventual nursing home admission.

    Full summary, score breakdown and related studies → Original source

  11. 2022-11-01

    FOOD INSECURITY AND COGNITIVE TRAJECTORIES IN COMMUNITY-DWELLING OLDER ADULTS

    ✓ Peer-reviewed Risk factors Innovation in Aging

    Key finding: Each year’s cognitive functions were linked to the prior year’s food insecurity values.

    Full summary, score breakdown and related studies → Original source

  12. 2022-11-01

    Is dietary choline intake related to dementia and Alzheimer's disease risks? Results from the Framingham Heart Study

    ✓ Peer-reviewed Long-term cohort studies The American journal of clinical nutrition

    Key finding: The positive association of choline for cognition has been reported in both animal and human studies, yet the associations of choline with the risks of incident dementia or Alzheimer's disease (AD) in humans is unclear. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2022-11-01

    Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau Burden

    ✓ Peer-reviewed Tau biomarkers JAMA network open

    Key finding: Heterozygosity of the KL-VS haplotype has been associated with reduced amyloid and tau burden. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2022-11-01

    Plaque contact and unimpaired Trem2 is required for the microglial response to amyloid pathology

    ✓ Peer-reviewed TREM2 and immune genetics Cell reports

    Key finding: In 18-month-old APP NL-F/NL-F knockin mice, with and without the Alzheimer's disease risk mutation Trem2 R47H/R47H , we report that expression of 38/55 PIGs have plaque-induced microglial upregulation, with a subset only upregulating in microglia directly contacting plaques. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2022-11-01

    Multi-method investigation of factors influencing amyloid onset and impairment in three cohorts

    ✓ Peer-reviewed Prevention and risk Brain : a journal of neurology

    Key finding: Cox regression and accelerated failure time models were used to investigate whether sex, apolipoprotein E genotype and e4 carriage were associated with amyloid onset age in all cohorts. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2022-11-01

    Evaluating the Safety and Efficacy of Crenezumab vs Placebo in Adults With Early Alzheimer Disease: Two Phase 3 Randomized Placebo-Controlled Trials

    ✓ Peer-reviewed Treatments JAMA neurology

    Key finding: There were 813 participants in CREAD (mean [SD] age, 70.7 [8.2] years; 483 female and 330 male) and 806 in CREAD2 (mean [SD] age, 70.9 [7.7] years; 456 female and 350 male). +1 more finding

    Full summary, score breakdown and related studies → Original source

October 2022 9

  1. 2022-10-31

    Association between air pollution and CSF sTREM2 in cognitively normal older adults: The CABLE study

    ✓ Peer-reviewed Risk factors Annals of clinical and translational neurology

    Key finding: Ambient 2-year averaged exposure of PM2.5 was associated with changes of neuroinflammatory markers, that is, CSF sTREM2 (β = -0.116, p = 0.0002). +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2022-10-31

    Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders

    ✓ Peer-reviewed Inflammation and the immune system Nature reviews. Neuroscience

    Key finding: This Review focuses on the role of astrocytes in disorders including Alzheimer disease, Parkinson disease, Huntington disease and amyotrophic lateral sclerosis. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2022-10-31

    Nrf2 regulates the arginase 1+ microglia phenotype through the initiation of TREM2 transcription, ameliorating depression-like behavior in mice

    ✓ Peer-reviewed TREM2 and immune genetics Translational psychiatry

    Key finding: However, the key molecular mechanism that mediates major depressive disorder (MDD) pathogenesis remains elusive. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2022-10-31

    Empagliflozin reduces kidney fibrosis and improves kidney function by alternative macrophage activation in rats with 5/6-nephrectomy

    ✓ Peer-reviewed TREM2 and immune genetics Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    Key finding: Sodium glucose cotransporter 2 (SGLT2) inhibitors originally developed for the treatment of type 2 diabetes are clinically very effective drugs halting chronic kidney disease progression. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2022-10-31

    The Link between Oxidative Stress, Mitochondrial Dysfunction and Neuroinflammation in the Pathophysiology of Alzheimer's Disease: Therapeutic Implications and Future Perspectives

    ✓ Peer-reviewed Caregiving Antioxidants (Basel, Switzerland)

    Key finding: Many clinical trials aiming at inhibiting amyloid plaque formation, increasing amyloid beta clearance, or inhibiting neurofibrillary tangle pathology yielded inconclusive results or failed.

    Full summary, score breakdown and related studies → Original source

  6. 2022-10-31

    Observational studies in Alzheimer disease: bridging preclinical studies and clinical trials

    ✓ Peer-reviewed Treatments Nature reviews. Neurology

    Key finding: In this Perspective, we highlight the importance of including well-designed observational studies as part of these efforts. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2022-10-31

    Herpes Viruses in the Baltimore Longitudinal Study of Aging: Associations With Brain Volumes, Cognitive Performance, and Plasma Biomarkers

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: These findings suggest an association of sHHV infection with white matter volume loss, attentional decline, and astrogliosis. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2022-10-30

    Diet in the Prevention of Alzheimer's Disease: Current Knowledge and Future Research Requirements

    ✓ Peer-reviewed Prevention and risk Nutrients

    Key finding: Despite it being widely known that diet has a significant impact on the prevention and progression of Alzheimer's disease, the literature data are still scarce and controversial. +1 more finding

    Full summary, score breakdown and related studies → Original source

  9. 2022-10-30

    Review of Advanced Drug Trials Focusing on the Reduction of Brain Beta-Amyloid to Prevent and Treat Dementia

    ✓ Peer-reviewed Drug development Journal of experimental pharmacology

    Key finding: Around this age, the number of neurons begins to gradually decrease in healthy brains, but brains of patients with AD show a marked increase in neuron death, often resulting in a significant loss of cognitive abilities. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →