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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 10,826–10,850 of 27,380 studies, newest first · page 434 of 1096.

December 2020 25

  1. 2020-12-29

    Multivariate genome wide association and network analysis of subcortical imaging phenotypes in Alzheimer's disease

    ✓ Peer-reviewed Genetics BMC genomics

    Key finding: In this paper, we used the MGAS (Multivariate Gene-based Association test by extended Simes procedure) tool to perform multivariate GWAS on eight AD-relevant subcortical imaging measures. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2020-12-29

    Multi-View Separable Pyramid Network for AD Prediction at MCI Stage by 18F-FDG Brain PET Imaging

    ✓ Peer-reviewed Long-term cohort studies IEEE transactions on medical imaging

    Key finding: Nevertheless, only part of MCI subjects could progress to AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2020-12-29

    Microglial activation in the right amygdala-entorhinal-hippocampal complex is associated with preserved spatial learning in AppNL-G-F mice

    ✓ Peer-reviewed Biomarkers NeuroImage

    Key finding: Elevated microglial activation in the right amygdala-entorhinal-hippocampal complex of App NL-G-F mice is associated with better spatial learning. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2020-12-28

    The Vagal Autonomic Pathway of COVID-19 at the Crossroad of Alzheimer's Disease and Aging: A Review of Knowledge

    ✓ Peer-reviewed Cognitive tests and assessment Journal of Alzheimer's disease reports

    Key finding: Coronavirus Disease 2019 (COVID-19) pandemic-triggered mortality is significantly higher in older than in younger populations worldwide. +2 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2020-12-28

    Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

    ✓ Peer-reviewed Biomarkers Journal of medicinal chemistry

    Key finding: The combination of the scaffolds of the cholinesterase inhibitor huprine Y and the antioxidant capsaicin results in compounds with nanomolar potencies toward human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) that retain or improve the antioxidant properties of capsaicin. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2020-12-28

    Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment

    ✓ Peer-reviewed TREM2 and immune genetics Redox biology

    Key finding: As the leading cause of tooth loss, periodontitis is characterized by irreversible alveolar bone loss and activated osteoclastogenic process, which might be closely related to the activated intracellular reactive oxygen species (ROS) in osteoclasts. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2020-12-27

    An Examination of Positive and Negative Dementia Caregiving Experiences

    ✓ Peer-reviewed Caregiving Clinical gerontologist

    Key finding: Enabling characteristics (e.g., race/ethnicity, caregiver education and employment and PWD education) and most predisposing characteristics (e.g., caregiver age, PWD age, relationship type) were not associated with any caregiving experience measures. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2020-12-27

    High Blood Pressure and Risk of Dementia: A Two-Sample Mendelian Randomization Study in the UK Biobank

    ✓ Peer-reviewed Long-term cohort studies Biological psychiatry

    Key finding: We tested the hypothesis that a causal relationship exists between systolic BP (SBP) and/or diastolic BP (DBP) and risk of Alzheimer's disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2020-12-26

    Potential Neuroregenerative and Neuroprotective Effects of Uridine/Choline-Enriched Multinutrient Dietary Intervention for Mild Cognitive Impairment: A Narrative Review

    ✓ Peer-reviewed Treatments Neurology and therapy

    Key finding: Evidence suggests that metabolic derangements associated with ageing and disease-related pathology can affect the body's ability to generate and utilize nutrients. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2020-12-25

    Long-term exposure to fine particulate matter and dementia incidence: A cohort study in Hong Kong

    ✓ Peer-reviewed Risk factors Environmental pollution (Barking, Essex : 1987)

    Key finding: Recent studies suggested that long-term exposure to fine particulate matter (PM2.5) was related to a higher risk of dementia incidence or hospitalizations in western populations, but the evidence is limited in Asian cities. +2 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2020-12-24

    Amyloid-β misfolding as a plasma biomarker indicates risk for future clinical Alzheimer's disease in individuals with subjective cognitive decline

    ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

    Key finding: A panel of structure- and concentration-based plasma amyloid biomarkers may predict conversion to clinical MCI and dementia due to AD in cognitively unimpaired subjects. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2020-12-24

    The Microbiota-Gut-Brain Axis and Alzheimer's Disease: Neuroinflammation Is to Blame?

    ✓ Peer-reviewed Inflammation and the immune system Nutrients

    Key finding: Various external and internal factors may contribute to the early onset of AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2020-12-23

    The Homestead: Developing a Conceptual Framework through Co-Creation for Innovating Long-Term Dementia Care Environments

    ✓ Peer-reviewed Health systems and care delivery International journal of environmental research and public health

    Key finding: Alternative care environments for regular nursing homes are highly warranted to promote health and well-being of residents with dementia that are part of an age-friendly and dementia-friendly city and society.

    Full summary, score breakdown and related studies → Original source

  14. 2020-12-23

    The sleep and circadian problems of Huntington's disease: when, why and their importance

    ✓ Peer-reviewed Risk factors Journal of neurology

    Key finding: This cycle is challenging to study, as its bidirectional nature renders cause difficult to disentangle from effect. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2020-12-23

    Reward motivation and cognitive flexibility in tau null-mutation mice

    ✓ Peer-reviewed Drug development Neurobiology of aging

    Key finding: These data indicate that tau loss of function alters reward processing.

    Full summary, score breakdown and related studies → Original source

  16. 2020-12-23

    Geographic Variation in Neurologist Density and Neurologic Care in the United States

    ✓ Peer-reviewed Risk factors Neurology

    Key finding: Mean density of neurologists varied nearly 4-fold from the lowest to the highest density quintile (9.7 [95% confidence interval (CI) 9.2-10.2] vs 43.1 [95% CI 37.6-48.5] per 100,000 Medicare beneficiaries). +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2020-12-22

    Attenuated CSF-1R signalling drives cerebrovascular pathology

    ✓ Peer-reviewed Vascular contributions EMBO molecular medicine

    Key finding: Finally, we show that endothelial/microglial crosstalk and concomitant attenuation of CSF-1R signalling causes re-modelling of BBB-associated tight junctions and suggest that regulating BBB integrity and systemic macrophage recruitment to the brain may be therapeutically relevant in ALSP and other Alzheimer's-like dementias.

    Full summary, score breakdown and related studies → Original source

  18. 2020-12-22

    APOE Variants in an Iberian Alzheimer Cohort Detected through an Optimized Sanger Sequencing Protocol

    ✓ Peer-reviewed Genetics Genes

    Key finding: The primary genetic risk factor for late onset Alzheimer's disease (LOAD) is the APOE4 allele of Apolipoprotein E (APOE) gene. +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2020-12-22

    Strategies for the use of Ginkgo biloba extract, EGb 761® , in the treatment and management of mild cognitive impairment in Asia: Expert consensus

    ✓ Peer-reviewed Prevention trials CNS neuroscience & therapeutics

    Key finding: EGb 761 ® is currently recommended in multiple guidelines for the symptomatic treatment of MCI. +1 more finding

    Full summary, score breakdown and related studies → Original source

  20. 2020-12-21

    Mitochondrial unfolded protein response: An emerging pathway in human diseases

    ✓ Peer-reviewed Disease mechanisms Free radical biology & medicine

    Key finding: Growing evidences suggests that UPRmt plays an important role in diverse human diseases, especially ageing-related diseases.

    Full summary, score breakdown and related studies → Original source

  21. 2020-12-21

    Deep Convolutional Neural Networks and Transfer Learning for Measuring Cognitive Impairment Using Eye-Tracking in a Distributed Tablet-Based Environment

    ✓ Peer-reviewed Cognitive tests and assessment IEEE transactions on bio-medical engineering

    Key finding: This work demonstrates a mobile version of VisMET capable of estimating the presence of cognitive impairment.

    Full summary, score breakdown and related studies → Original source

  22. 2020-12-21

    Spicy food consumption is associated with cognition and cerebrospinal fluid biomarkers of Alzheimer disease

    ✓ Peer-reviewed Tau biomarkers Chinese medical journal

    Key finding: This study aimed to investigate whether spicy food consumption is associated with cognition and cerebrospinal fluid (CSF) biomarkers of AD in the Chinese population. +3 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2020-12-21

    Frequency of Biologically Defined Alzheimer Disease in Relation to Age, Sex, APOE ε4, and Cognitive Impairment

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: The clinical diagnosis of probable AD dementia demonstrated good agreement with biologically defined AD (positive predictive value 85.2%). +2 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2020-12-19

    Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration

    ✓ Peer-reviewed Inflammation and the immune system Neurobiology of disease

    Key finding: Pathway enrichment analyses also revealed the upregulation of neuroinflammation (including Toll-like receptor, TNF, and NFκB signaling) and phagocytosis, and the downregulation of mitochondrial oxidative phosphorylation, lysosomal acidification, and ubiquitin-proteasome pathways. +1 more finding

    Full summary, score breakdown and related studies → Original source

  25. 2020-12-18

    Choosing the right time granularity for analysis of digital biomarker trajectories

    ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia (New York, N. Y.)

    Key finding: We applied our procedure to real-world data which include longitudinal in-home monitored walking speed. +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →