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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 10,601–10,625 of 27,380 studies, newest first · page 425 of 1096.

February 2021 4

  1. 2021-02-01

    Increased APOE ε4 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds

    ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: AD patients with ELA expressed significantly greater levels of APOE than ALA APOE ε4 carriers. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2021-02-01

    Association of Plasma Neurofilament Light With Small Vessel Disease Burden in Nondemented Elderly: A Longitudinal Study

    ✓ Peer-reviewed Biomarkers Stroke

    Key finding: Plasma NfL level is a valuable noninvasive biomarker that supplements magnetic resonance imaging scans and possibly reflects the severity of CSVD burden. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2021-02-01

    Association Between Ambient Air Pollution and Amyloid Positron Emission Tomography Positivity in Older Adults With Cognitive Impairment

    ✓ Peer-reviewed Biomarkers JAMA neurology

    Key finding: The data set included 18 178 patients, of which 10 991 (60.5%) had MCI and 7187 (39.5%) had dementia (mean [SD] age, 75.8 [6.3] years; 9333 women [51.3%]). +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-02-01

    Associations of Plasma Phospho-Tau217 Levels With Tau Positron Emission Tomography in Early Alzheimer Disease

    ✓ Peer-reviewed Biomarkers JAMA neurology

    Key finding: Of 490 participants, 251 were women (51.2%) and the mean (SD) age was 65.9 (13.1) years. +3 more findings

    Full summary, score breakdown and related studies → Original source

January 2021 21

  1. 2021-01-31

    Relation among Caregivers' Burden, Abuse and Behavioural Disorder in People with Dementia

    ✓ Peer-reviewed Caregiving International journal of environmental research and public health

    Key finding: The data showed that 45.50 per cent of caregivers have light burden or burden.

    Full summary, score breakdown and related studies → Original source

  2. 2021-01-31

    Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer's disease neuropathology

    ✓ Peer-reviewed Treatments Molecular neurodegeneration

    Key finding: We identify Clu as an astrocyte-derived synaptogenic and anti-amyloid factor; the combination of these activities may influence the progression of late-onset AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2021-01-30

    Tauvid™: The First FDA-Approved PET Tracer for Imaging Tau Pathology in Alzheimer's Disease

    ✓ Peer-reviewed Brain scans and imaging Pharmaceuticals (Basel, Switzerland)

    Key finding: Food and Drug Administration (FDA) in 2020 for positron emission tomography (PET) imaging of adult patients with cognitive impairments undergoing evaluation for Alzheimer's disease (AD) based on tau pathology. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-01-30

    Magnesium in Aging, Health and Diseases

    ✓ Peer-reviewed Risk factors Nutrients

    Key finding: Numerous human diseases have been associated with Mg deficits, including cardiovascular diseases, hypertension and stroke, cardio-metabolic syndrome and type 2 diabetes mellitus, airways constrictive syndromes and asthma, depression, stress-related conditions and psychiatric disorders, Alzheimer's disease (AD) and other dementia syndromes, muscular diseases (muscle pain, chronic fatigue, and fibromyalgia), bone fragility, and cancer. +2 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2021-01-30

    TauIQ: A Canonical Image Based Algorithm to Quantify Tau PET Scans

    ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    Key finding: Tau IQ successfully calculated global tau load (Tau L ) in all 791 scans analyzed (range, -3.5% to 185.2%; mean ± SD, 23% ± 20.5%) with a nonzero additional local tau component being required in 31% of all scans (cognitively normal [CN], 22%; mild cognitive impairment [MCI], 35%; dementia, 72%). +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2021-01-29

    Gut Microbiome Features of Chinese Patients Newly Diagnosed with Alzheimer’s Disease or Mild Cognitive Impairment

    ✓ Peer-reviewed Disease mechanisms Journal of Alzheimer s Disease

    Key finding: Although there was no difference in the microbial α-diversity among the three groups, patients with AD or MCI had increased β-diversity compared with healthy controls. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2021-01-29

    How Comorbidity Reflects on Cerebrospinal Fluid Biomarkers of Neurodegeneration in Aging

    ✓ Peer-reviewed Tau biomarkers Journal of Alzheimer's disease reports

    Key finding: These preliminary findings suggested that, in normal subjects, systemic comorbidity might increase CNS oxidative stress and, together with aging, contribute to develop an Alzheimer's disease-like biochemical profile.

    Full summary, score breakdown and related studies → Original source

  8. 2021-01-29

    Disorders of the enteric nervous system - a holistic view

    ✓ Peer-reviewed Disease mechanisms Nature reviews. Gastroenterology & hepatology

    Key finding: Data indicate that changes in the gut microbiome acting in concert with the individual genetic background can modify the ENS, central nervous system and the immune system, impair barrier function, and contribute to various disorders such as irritable bowel syndrome, inflammatory bowel disease or neurodegeneration.

    Full summary, score breakdown and related studies → Original source

  9. 2021-01-29

    Effects of statins on mitochondrial pathways

    ✓ Peer-reviewed Drug development Journal of cachexia, sarcopenia and muscle

    Key finding: Studies have shown that mitochondria play an important role in statin-induced myopathies. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2021-01-29

    Association of Early β-Amyloid Accumulation and Neuroinflammation Measured With [11C]PBR28 in Elderly Individuals Without Dementia

    ✓ Peer-reviewed Tau biomarkers Neurology

    Key finding: We examined 54 volunteers (mean age 70.0 years, 56% women, 51% APOE ɛ4 carriers) with the translocator protein (TSPO) tracer [ 11 C]PBR28 to assess neuroinflammation and with [ 11 C] Pittsburgh compound B (PiB) to assess cerebral Aβ accumulation. [ 11 C]PBR28 and [ 11 C]PiB standardized uptake value ratios (SUVRs) were quantified in 6 regions of interests by using the cerebellar cortex as a pseudo-reference and reference region, respectively. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2021-01-29

    Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: A harmful synergistic path in down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Free radical biology & medicine

    Key finding: This phenomenon, known as brain insulin resistance, is associated with poor cognitive performance and is driven by the inhibition of IRS1. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2021-01-29

    A multilayer multimodal detection and prediction model based on explainable artificial intelligence for Alzheimer's disease

    ✓ Peer-reviewed Digital health tools Scientific reports

    Key finding: As a result, physicians struggle to interpret these models, and feel it is hard to trust them.

    Full summary, score breakdown and related studies → Original source

  13. 2021-01-28

    Aerobic exercise improves hippocampal blood flow for hypertensive Apolipoprotein E4 carriers

    ✓ Peer-reviewed Prevention trials Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    Key finding: For APOE4 carriers, change in HBF (ΔHBF) was significantly (p = 0.006) higher for participants in the exercise intervention (4.09 mL/100g/min) than the control group (-2.08 mL/100g/min).

    Full summary, score breakdown and related studies → Original source

  14. 2021-01-28

    Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis

    ✓ Peer-reviewed Genetics Nature genetics

    Key finding: To that end, we integrated AD GWAS results with human brain proteomes to perform a proteome-wide association study (PWAS) of AD, followed by Mendelian randomization and colocalization analysis. +2 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2021-01-28

    The key role of solvent in condensation: Mapping water in liquid-liquid phase-separated FUS

    ✓ Peer-reviewed Clinical safety Biophysical journal

    Key finding: With terahertz spectroscopy, we revealed a dewetting of hydrophobic side chains in phase-separated FUS.

    Full summary, score breakdown and related studies → Original source

  16. 2021-01-28

    TREM2, microglia, and Alzheimer's disease

    ✓ Peer-reviewed TREM2 and immune genetics Mechanisms of ageing and development

    Key finding: Since then, rapidly increasing literature related to TREM2 has focused on elucidating its role in AD pathology. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2021-01-27

    Fluorescent Determination of Butyrylcholinesterase Activity and Its Application in Biological Imaging and Pesticide Residue Detection

    ✓ Peer-reviewed Risk factors ACS Sensors

    Key finding: In this work, a background-free detection strategy was built by virtue of the judicious coupling of a specific BChE-enzymatic reaction and in situ cyclization. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2021-01-27

    Traumatic Spinal Cord Injury and Risk of Early and Late Onset Alzheimer's Disease and Related Dementia: Large Longitudinal Study

    ✓ Peer-reviewed Digital health tools Archives of physical medicine and rehabilitation

    Key finding: Adults with TSCI are at a heightened risk for ADRD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2021-01-27

    The Impact of Dementia on Cancer Treatment Decision-Making, Cancer Treatment, and Mortality: A Mixed Studies Review

    ✓ Peer-reviewed End-of-life care JNCI cancer spectrum

    Key finding: Summarized findings from qualitative studies consistently revealed that clinicians, caregivers, and patients tended to prefer less aggressive care and gave higher priority to quality of life over life expectancy for those with dementia.

    Full summary, score breakdown and related studies → Original source

  20. 2021-01-26

    Mild behavioral impairment and its relation to tau pathology in preclinical Alzheimer's disease

    ✓ Peer-reviewed Brain scans and imaging Translational psychiatry

    Key finding: We found that higher tau-PET signal in the entorhinal cortex/hippocampus and CSF P-tau 181 levels were associated with higher MBI-C scores (β = 0.010, SE = 0.003, p = 0.003 and β = 1.263, SE = 0.446, p = 0.007, respectively). +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2021-01-25

    Cognitive reserve and brain maintenance in aging and dementia: An integrative review

    ✓ Peer-reviewed Risk factors Applied neuropsychology. Adult

    Key finding: We also analyze lifestyle factors associated with brain maintenance or the relative absence of change in neural resources over time. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →