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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 9,476–9,500 of 27,380 studies, newest first · page 380 of 1096.

December 2021 25

  1. 2021-12-27

    Effects of gut microbiota and probiotics on Alzheimer's disease

    ✓ Peer-reviewed Disease mechanisms Translational neuroscience

    Key finding: Alzheimer's disease (AD) is a progressive neurodegenerative disease with high morbidity, disability, and fatality rate, significantly increasing the global burden of public health.

    Full summary, score breakdown and related studies → Original source

  2. 2021-12-24

    Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer's disease

    ✓ Peer-reviewed TREM2 and immune genetics Molecular immunology

    Key finding: Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia-specific receptor in the brain that is involved in regulating neuroinflammation. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2021-12-23

    A randomized controlled trial of the "positive diary" intervention for family caregivers of people with dementia

    ✓ Peer-reviewed Caregiving Perspectives in psychiatric care

    Key finding: The intervention group showed improvement on several measures of wellbeing including Neuropsychiatric Inventory Questionnaire and Center for Epidemiologic Studies Depression Scale. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2021-12-23

    The Association Between Loneliness and Psychiatric Symptomatology in Older Psychiatric Outpatients

    ✓ Peer-reviewed Risk factors Journal of geriatric psychiatry and neurology

    Key finding: Loneliness was associated with having contacts in less social network domains, in women but not in men. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2021-12-23

    Affective Computing for Late-Life Mood and Cognitive Disorders

    ✓ Peer-reviewed Risk factors Frontiers in psychiatry

    Key finding: Affective computing (also referred to as artificial emotion intelligence or emotion AI) is the study and development of systems and devices that can recognize, interpret, process, and simulate emotion or other affective phenomena. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2021-12-23

    Resistance-exercise training attenuates LPS-induced astrocyte remodeling and neuroinflammatory cytokine expression in female Wistar rats

    ✓ Peer-reviewed Prevention trials Journal of applied physiology (Bethesda, Md. : 1985)

    Key finding: Our data demonstrated that resistance training had an anti-inflammatory effect in the brain as LPS-induced neuroinflammatory cytokine expression and reactive astrocytic remodeling were reduced in the dentate gyrus after 3 wk of progressive ladder climbing.

    Full summary, score breakdown and related studies → Original source

  7. 2021-12-23

    Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide

    ✓ Peer-reviewed Drug development Nature medicine

    Key finding: In a single patient harboring mutant C9ORF72 with the G 4 C 2 repeat expansion, repeated dosing by intrathecal delivery of the optimal ASO was well tolerated, leading to significant reductions in levels of cerebrospinal fluid poly(GP).

    Full summary, score breakdown and related studies → Original source

  8. 2021-12-23

    Adherence to a MIND-Like Dietary Pattern, Long-Term Exposure to Fine Particulate Matter Air Pollution, and MRI-Based Measures of Brain Volume: The Women's Health Initiative Memory Study-MRI

    ✓ Peer-reviewed Prevention trials Environmental health perspectives

    Key finding: In this cohort of U.S. women, PM2.5 exposure was associated with lower MRI-based WMV, an indication of brain aging, only among women whose usual diet was less consistent with the MIND-like dietary pattern at baseline. https://doi.org/10.1289/EHP8036. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2021-12-23

    A case report of late-onset schizophrenia differentiated from a dementing disorder

    ✓ Peer-reviewed Tau biomarkers Neurocase

    Key finding: The patient was an 83-year-old woman who had experienced auditory hallucinations since she was 67 years old. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2021-12-22

    Inflammasome activation in neurodegenerative diseases

    ✓ Peer-reviewed Inflammation and the immune system Essays in biochemistry

    Key finding: NLRP3 inhibitor treatment has shown promising results in several preclinical mouse models of AD, PD, and ALS.

    Full summary, score breakdown and related studies → Original source

  11. 2021-12-22

    Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview

    ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: The (pre-)analytical procedures were similar between centers. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2021-12-22

    Association of CSF Aβ38 Levels With Risk of Alzheimer Disease-Related Decline

    ✓ Peer-reviewed Long-term cohort studies Neurology

    Key finding: Experimental studies suggest that the balance between short and long β-amyloid (Aβ) species might modulate the toxic effects of Aβ in Alzheimer disease (AD), but clinical evidence is lacking. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2021-12-22

    Vascular Cognitive Impairment (VCI)

    ✓ Peer-reviewed Prevention and risk Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    Key finding: Growing evidence indicates that cerebrovascular pathology is the most important contributor to dementia, with additive or synergistic interactions with neurodegenerative pathology. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2021-12-21

    Frailty, lifestyle, genetics and dementia risk

    ✓ Peer-reviewed Prevention and risk Journal of neurology, neurosurgery, and psychiatry

    Key finding: Frailty is strongly associated with dementia risk and affects the risk attributable to genetic factors. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2021-12-20

    Toward a broader concept of societal value: family spillovers in Alzheimer's disease

    ✓ Peer-reviewed Costs and economics International journal of technology assessment in health care

    Key finding: Recognizing that the "healthcare sector perspective" can be too limited in some situations, the National Institute of Health and Care Excellence (NICE), Institute for Clinical and Economic Review (ICER), and the U.S. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2021-12-20

    Complement System in Alzheimer's Disease

    ✓ Peer-reviewed Inflammation and the immune system International journal of molecular sciences

    Key finding: It is a progressive, neurodegenerative disorder. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2021-12-20

    Perivascular space dilation is associated with vascular amyloid-β accumulation in the overlying cortex

    ✓ Peer-reviewed Digital health tools Acta neuropathologica

    Key finding: Severity of MRI-visible PVS during life was significantly associated with severity of MRI-visible PVS on ex vivo MRI in formalin fixed intact hemispheres and corresponded with PVS enlargement on histopathology in the same areas. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2021-12-20

    What have we learned from past failures of investigational drugs for Alzheimer's disease?

    ✓ Peer-reviewed Drug development Expert opinion on investigational drugs

    Key finding: In the last 15 years, huge efforts against Alzheimer's disease (AD) with drugs targeting β-amyloid (Aβ) and tau have produced poor clinical results. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2021-12-20

    TDP-43 Pathology in Alzheimer's Disease

    ✓ Peer-reviewed Lewy body dementia Molecular neurodegeneration

    Key finding: AD patients with TDP-43 pathology have increased severity of cognitive impairment compared to those without TDP-43 pathology. +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2021-12-18

    Biomarkers used in Alzheimer's disease diagnosis, treatment, and prevention

    ✓ Peer-reviewed Disease mechanisms Ageing research reviews

    Key finding: In the end, we have presented a separate elaboration on aspects of future perspectives and concluding remarks.

    Full summary, score breakdown and related studies → Original source

  21. 2021-12-18

    Neuropathology and molecular diagnosis of Synucleinopathies

    ✓ Peer-reviewed Getting a diagnosis Molecular neurodegeneration

    Key finding: It remains unclear how α-synuclein can be associated with distinct cellular pathologies (e.g., Lewy bodies and glial cytoplasmic inclusions) and what factors determine neuroanatomical and cell type vulnerability. +1 more finding

    Full summary, score breakdown and related studies → Original source

  22. 2021-12-17

    Patient cognitive impairment associated with higher home health care delivery costs

    ✓ Peer-reviewed Health systems and care delivery Health services research

    Key finding: To assess whether home health agencies incur significantly higher care delivery costs for patients with cognitive impairment across three timeframes relevant to home health payment policy. +1 more finding

    Full summary, score breakdown and related studies → Original source

  23. 2021-12-17

    Recent update on the heterogeneity of the Alzheimer's disease spectrum

    ✓ Peer-reviewed Genetics Journal of neural transmission (Vienna, Austria : 1996)

    Key finding: In addition to "classical" AD, several subtypes with characteristic regional patterns of tau pathology have been segregated that are characterized by distinct clinical features, differences in age, sex distribution, disease duration, cognitive status, APOE genotype, and biomarker levels. +4 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2021-12-16

    Liraglutide Reduces Vascular Damage, Neuronal Loss, and Cognitive Impairment in a Mixed Murine Model of Alzheimer’s Disease and Type 2 Diabetes

    ✓ Peer-reviewed Drug development Frontiers in Aging Neuroscience

    Key finding: While we did not detect any effects on cortical insulin or insulin-like growth factor 1 receptor m-RNA levels, LRGT significantly reduced brain atrophy in the db/db and APP/PS1xdb/db mice. +1 more finding

    Full summary, score breakdown and related studies → Original source

  25. 2021-12-16

    Sleep apnoea and cognitive impairment: myth or reality?

    ✓ Peer-reviewed Risk factors Geriatrie et psychologie neuropsychiatrie du vieillissement

    Key finding: In the absence of curative treatment, it is therefore important to consider any comorbidities that may influence the course of AD such as obstructive sleep apnoea-hypnoea (OSAH) and its syndrome (OSAHS), which appear to be potentially interesting because it occurs frequently, it is treatable and it is often associated with cognitive impairment. +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →