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Relationship Between the Gut Microbiota and Alzheimer's Disease: A Systematic Review
Elisa Marina González Cordero, Miguel Angel Cuevas-Budhart, Diana Pérez Morán, Miguel Angel Trejo Villeda, Mercedes Gomez-Del-Pulgar Gª-Madrid. Journal of Alzheimer's disease : JAD, 2022
Topic: Gut, metabolism and diet
Eight observational studies were selected, carried out in humans and, therefore, suitable for inclusion in this review. The results of these studies support the hypothesis that there is a relationship between the gut microbiota and cognitive disorders through the gut-brain axis. However, today, there is a substantial lack of human studies, especially clinical trials, which makes it difficult to formulate clinical recommendations on this topic.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Cordero, E. M. G., Cuevas-Budhart, M. A., Morán, D. P., Villeda, M. A. T., & Gª-Madrid, M. G.-D.-P. (2022). Relationship Between the Gut Microbiota and Alzheimer's Disease: A Systematic Review. Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-215224
Vancouver
Cordero EMG, Cuevas-Budhart MA, Morán DP, Villeda MAT, Gª-Madrid MG.-D.-P. Relationship Between the Gut Microbiota and Alzheimer's Disease: A Systematic Review. Journal of Alzheimer's disease : JAD. 2022. doi:10.3233/jad-215224. PMID: 35367961.
BibTeX
@article{cordero2022-35367961,
author = {Cordero, Elisa Marina González and Cuevas-Budhart, Miguel Angel and Morán, Diana Pérez and Villeda, Miguel Angel Trejo and Gª-Madrid, Mercedes Gomez-Del-Pulgar},
title = {{Relationship Between the Gut Microbiota and Alzheimer's Disease: A Systematic Review}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2022},
doi = {10.3233/jad-215224},
pmid = {35367961},
url = {https://doi.org/10.3233/jad-215224}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Eight observational studies were selected, carried out in humans and, therefore, suitable for inclusion in this review.
- The results of these studies support the hypothesis that there is a relationship between the gut microbiota and cognitive disorders through the gut-brain axis.
- However, today, there is a substantial lack of human studies, especially clinical trials, which makes it difficult to formulate clinical recommendations on this topic.
Study details
- Study designnarrative review
- Evidence strengthLow
How this study scored 63/100
Published in a peer-reviewed journal, and it is a systematic review of all the studies on the question. Scored zero for sample size, effect reported and studied in people because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 35 of the 56 points we could judge it on, which is 63 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 12 / 12 | A systematic review of all the studies on the question (from PubMed type “Systematic Review”) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35367961) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 35 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 35 of the 56 points we could judge it on is 63 out of 100. |
| Total | 63 / 100 | — |
What each of these 20 components measures, and what this score is not →
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