Newest studies

Anticipated reactions to learning Alzheimer's disease biomarker results

66/100 ✓ Peer-reviewed Disparities Alzheimer's research & therapy

Key finding: Two models comprising behavior change and psychological impact fit well for the total sample and the two racial groups. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Transcriptomic Profile of Blood-Brain Barrier Remodeling in Cerebral Amyloid Angiopathy

41/100 ✓ Peer-reviewed Vascular contributions Frontiers in cellular neuroscience

Key finding: It is commonly associated with late-stage Alzheimer's disease. +3 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Specific Cerebrospinal Fluid SerpinA1 Isoform Pattern in Alzheimer's Disease

54/100 ✓ Peer-reviewed Biomarkers International journal of molecular sciences

Key finding: Four CSF serpinA1 isoforms were differently expressed in AD patients compared to controls and LBD patients, especially isoforms 2 and 4. +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Diagnosis of coexistent neurodegenerative dementias in multiple sclerosis

41/100 ✓ Peer-reviewed Tau biomarkers Brain communications

Key finding: Some multiple sclerosis patients present with severe cognitive impairment, and distinguishing multiple sclerosis-related cognitive impairment from co-existent progressive neurodegenerative diseases such as Alzheimer disease poses a diagnostic challenge. +3 more findings

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Mouse Models of Alzheimer's Disease

49/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in molecular neuroscience

Key finding: The pathological hallmarks of AD are senile plaques and neurofibrillary tangles, which comprise abnormally aggregated β-amyloid peptide (Aβ) and hyperphosphorylated tau protein. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH

51/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of hepatology

Key finding: & aims Previous single-cell RNA-sequencing analyses have shown that Trem2-expressing macrophages are present in the liver during obesity, non-alcoholic steatohepatitis (NASH) and cirrhosis. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Multimodal deep learning for Alzheimer's disease dementia assessment

47/100 ✓ Peer-reviewed Digital health tools Nature communications

Key finding: Here, we report a deep learning framework that accomplishes multiple diagnostic steps in successive fashion to identify persons with normal cognition (NC), mild cognitive impairment (MCI), AD, and non-AD dementias (nADD). +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Effects of multi-component non-pharmacological interventions on cognition in participants with mild cognitive impairment: A systematic review and meta-analysis

67/100 ✓ Peer-reviewed Prevention trials Archives of gerontology and geriatrics

Key finding: Our analyses support that MNPI could improve the global cognition in older adults with MCI.

• Early Stage
• Clinical Trials

Full summary, score breakdown and related studies → Original source

LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions

46/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration

Key finding: Microglia plays crucial roles in Alzheimer's disease (AD) development. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

48/100 ✓ Peer-reviewed Inflammation and the immune system Molecular neurodegeneration

Key finding: In the absence of effective therapeutic interventions, identifying risk factors associated with cognitive decline becomes increasingly vital. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Quality of end-of-life nursing home care in dementia: relatives' perceptions

52/100 ✓ Peer-reviewed Health systems and care delivery BMJ supportive & palliative care

Key finding: In total, 208 (response rate2010: 51.05%, response rate2015=60.65%) bereaved relatives responded to the questionnaire. +3 more findings

• Care Services
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Are Brain and Cognitive Reserve Shaped by Early Life Circumstances?

41/100 ✓ Peer-reviewed Risk factors Frontiers in neuroscience

Key finding: Although neuropathological signs of dementia disorders can often be demonstrated in brains of patients, the degree to which clinical symptoms are present does mostly not accurately reflect the amount of neuropathology that is present. +2 more findings

Full summary, score breakdown and related studies → Original source

Self-reported hearing loss, hearing aid use, and cognitive function among U.S. older adults

57/100 ✓ Peer-reviewed Risk factors International journal of population studies

Key finding: The purpose of this report is to examine how age-related changes in hearing loss and hearing aid use are associated with trajectories of cognitive function in a nationally-representative sample of U.S. older adults. +3 more findings

• Risk Factors
• Lifestyle
• Health Equity

Full summary, score breakdown and related studies → Original source

Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimer´s-like pathology

34/100 ✓ Peer-reviewed Biomarkers F1000Research

Key finding: We observed that mice lacking IR in GFAP astrocytes (GFAP IR KO mice) develop mood disturbances and maintained intact cognition, while at the same time show greater pathology when cross-bred with APP/PS1 mice, a model of familial Alzheimer´s disease (AD). +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Staging of Alzheimer's disease: past, present, and future perspectives

41/100 ✓ Peer-reviewed Tau biomarkers Trends in molecular medicine

Key finding: For many years Alzheimer's disease (AD) was associated with the dementia stage of the disease, the tail end of a pathophysiological process that lasts approximately two decades.

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

Microglial amyloid beta clearance is driven by PIEZO1 channels

43/100 ✓ Peer-reviewed Genetics Journal of neuroinflammation

Key finding: These results indicate that the compromised function of microglia in AD could be improved by controlled activation of PIEZO1 channels resulting in alleviated Aβ burden. +4 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Long term high fat diet induces metabolic disorders and aggravates behavioral disorders and cognitive deficits in MAPT P301L transgenic mice

38/100 ✓ Peer-reviewed Tau biomarkers Metabolic brain disease

Key finding: Given the link between peripheral insulin resistance and tau pathology in streptozotocin-injected and db/db mouse models of diabetes, we fed high fat diet (HFD) to pR5 mice expressing P301L mutant human tau, with the aim of developing a new model with characteristics of obesity, T2DM and AD to mimic AD patients exacerbated by obesity and T2DM, an increasing trend in modern society. +3 more findings

• Brain Biology
• Lifestyle

Full summary, score breakdown and related studies → Original source

Deprescribing Interventions by Palliative Care Clinical Pharmacists Surrounding Goals of Care Discussions

48/100 ✓ Peer-reviewed End-of-life care Journal of palliative medicine

Key finding: Eighty-two percent of recommendations were successfully implemented during hospitalization and included in the discharge plan. +3 more findings

• Side Effects
• End-of-Life Care
• Treatments

Full summary, score breakdown and related studies → Original source

Promoting activity in long-term care facilities with the social robot Pepper: a pilot study

41/100 ✓ Peer-reviewed Health systems and care delivery Informatics for health & social care

Key finding: After a series of interventions with the robot in a long-term care facility, data were collected through individual interviews with healthcare professional and residents. +4 more findings

• Care Services
• Digital Tools

Full summary, score breakdown and related studies → Original source

Dementia and COVID-19 infection control in assisted living in seven states

41/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society

Key finding: Less than half of administrators found it feasible to close indoor common areas, all community types reported a challenge organizing group activities for safe distancing, and more than half of residents with dementia did not wear a face covering or maintain physical distance from other residents when indicated. +3 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Association of Visual, Hearing, and Dual Sensory Impairment With Incident Dementia

59/100 ✓ Peer-reviewed Risk factors Frontiers in aging neuroscience

Key finding: Among 113,511 participants (mean age: 56.8 ± 8.09 years, female: 54.4%), a total number of 1,135 (1.00%) cases of incident dementia were identified during a median follow up period of 11.1 years [interquartile range (IQR): 10.9-11.4 years]. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Cerebrospinal fluid proteomic profiling of individuals with mild cognitive impairment and suspected non-Alzheimer's disease pathophysiology

52/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: A total of 96 proteins were decreased in MCI-SNAP compared to CN and MCI-AD. +4 more findings

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

Test-retest variability of plasma biomarkers in Alzheimer's disease and its effects on clinical prediction models

47/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Clinical prediction models combining plasma biomarkers-particularly p-tau217-exhibit high performance and are less effected by random error.

• Biomarkers

Full summary, score breakdown and related studies → Original source

Computerized cognitive training in Parkinson's disease: A systematic review and meta-analysis

76/100 ✓ Peer-reviewed Prevention trials Ageing research reviews

Key finding: The pooled effect of CCT relative to control was small and statistically significant for overall cognitive function (g=0.16; 95% CI 0.02-0.29). +3 more findings

• Other Dementias
• Lifestyle
• Digital Tools

Full summary, score breakdown and related studies → Original source

Cataract, Cataract Surgery, and Risk of Incident Dementia: A Prospective Cohort Study of 300,823 Participants

52/100 ✓ Peer-reviewed Long-term cohort studies Biological psychiatry

Key finding: Visual impairment and interventions to preserve vision may impact dementia risk. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source