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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 21,851–21,875 of 27,380 studies, newest first · page 875 of 1096.

October 2008 10

  1. 2008-10-01

    Why do so many drugs for Alzheimer's disease fail in development? Time for new methods and new practices?

    ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer's disease : JAD

    Key finding: Alzheimer's disease (AD) drug developments and clinical trials (CT) remain vulnerable to problems that undermine research validity. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2008-10-01

    Development of methodology for conducting clinical trials in frontotemporal lobar degeneration

    ✓ Peer-reviewed Lewy body dementia Brain : a journal of neurology

    Key finding: Two global measures, the FTLD-modified Clinical Dementia Rating (FTLD-modified CDR) and the Clinical Global Impression of Change (CGIC) demonstrated decline in the majority of patients. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2008-10-01

    The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4

    ✓ Peer-reviewed Down syndrome and Alzheimer's Neuroscience

    Key finding: In support of a physiological relation in the brain, we found that Dyrk1A and Sept4 are co-expressed and co-localized in neocortical neurons. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2008-10-01

    Prevalence of neuropsychiatric symptoms in mild cognitive impairment and normal cognitive aging: population-based study

    ✓ Peer-reviewed How common it is Archives of general psychiatry

    Key finding: Multivariate logistic regression analyses were conducted after adjusting for age, sex, and educational status.

    Full summary, score breakdown and related studies → Original source

  5. 2008-10-01

    Brain behavior relationships among African Americans, whites, and Hispanics

    ✓ Peer-reviewed Disparities Alzheimer disease and associated disorders

    Key finding: Hispanic subjects were, on average, significantly younger and had less years of education than African Americans or whites. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2008-10-01

    Determinants of burden in those who care for someone with dementia

    ✓ Peer-reviewed Caregiving International journal of geriatric psychiatry

    Key finding: These results confirm previous correlational research on caregiver burden. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2008-10-01

    Subjective cognitive failures and hippocampal volume in elderly with white matter lesions

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: Subjective cognitive failures (SCF) are associated with lower hippocampal volume, even in subjects without objective cognitive impairment and independent of white matter lesions. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2008-10-01

    Cerebral white matter: neuroanatomy, clinical neurology, and neurobehavioral correlates

    ✓ Peer-reviewed Getting a diagnosis Annals of the New York Academy of Sciences

    Key finding: Lesions of the cerebral white matter (WM) result in focal neurobehavioral syndromes, neuropsychiatric phenomena, and dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2008-10-01

    High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial

    ✓ Peer-reviewed Treatments JAMA

    Key finding: Trial registration clinicaltrials.gov Identifier: NCT00056225.

    Full summary, score breakdown and related studies → Original source

  10. 2008-10-01

    Prevalence of vitamin d insufficiency in patients with Parkinson disease and Alzheimer disease

    ✓ Peer-reviewed Genetics Archives of neurology

    Key finding: This report of 25(OH)D concentrations in a predominantly white PD cohort demonstrates a significantly higher prevalence of hypovitaminosis in PD vs both healthy controls and patients with AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

September 2008 15

  1. 2008-09-28

    Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology

    ✓ Peer-reviewed Caregiving Nature medicine

    Key finding: We found that the N-terminal pE-formation is catalyzed by glutaminyl cyclase in vivo.

    Full summary, score breakdown and related studies → Original source

  2. 2008-09-25

    Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia

    ✓ Peer-reviewed Brain scans and imaging Journal of neurology

    Key finding: 55 of the 152 (36.2 %) aMCI subjects progressed to AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2008-09-24

    Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta

    ✓ Peer-reviewed Tau biomarkers Neurogenetics

    Key finding: Alleles in ACE, APOE, BDNF, DAPK1, and TF are significantly associated with CSF Abeta levels.

    Full summary, score breakdown and related studies → Original source

  4. 2008-09-23

    Longitudinal changes in memory and executive functioning are associated with longitudinal change in instrumental activities of daily living in older adults

    ✓ Peer-reviewed Caregiving The Clinical neuropsychologist

    Key finding: Although many previous studies have demonstrated a cross-sectional relationship between cognition (particularly executive functions and memory) and everyday function in older adults, very little is known about longitudinal relationships between these domains. +2 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2008-09-21

    Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

    ✓ Peer-reviewed Disease mechanisms Nature medicine

    Key finding: Additionally, they have an increased calcium buffering capacity and generate fewer mitochondrial reactive oxygen species. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2008-09-21

    Cardiovascular risk and memory in non-demented elderly women

    ✓ Peer-reviewed Treatments Neurobiology of aging

    Key finding: These findings suggest that subtle elevation of CHD risk may negatively affect memory functioning even in otherwise healthy, non-demented older women without a history of heart disease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2008-09-19

    Inverse association of cortisol serum levels with T-tau, P-tau 181 and P-tau 231 peptide levels and T-tau/Abeta 1-42 ratios in CSF in patients with mild Alzheimer's disease dementia

    ✓ Peer-reviewed Tau biomarkers European archives of psychiatry and clinical neuroscience

    Key finding: Experimental studies point to an influence of cortisol on Abeta and tau pathology in AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2008-09-19

    Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis

    ✓ Peer-reviewed Lewy body dementia PLoS genetics

    Key finding: In this study, we report the identification and functional analyses of two novel and one known mutation in TARDBP that we identified as a result of extensive mutation analyses in a cohort of 296 patients with variable neurodegenerative diseases associated with TDP-43 histopathology. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2008-09-18

    Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

    ✓ Peer-reviewed Genetics The Journal of Pathology

    Key finding: We previously showed that herpes simplex virus type 1 is a strong risk factor for Alzheimer's disease when in the brains of possessors of the type 4 allele of the apolipoprotein E gene (APOE-epsilon4), and that beta-amyloid, the main component of plaques, accumulates in herpes simplex virus type 1-infected cell cultures and mouse brain. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2008-09-18

    An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells

    ✓ Peer-reviewed Drug development The Journal of biological chemistry

    Key finding: Human brains retain discrete populations of micro RNA (miRNA) species that support homeostatic brain gene expression functions; however, specific miRNA abundance is significantly altered in neurological disorders such as Alzheimer disease (AD) when compared with age-matched controls. +2 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2008-09-18

    VCP disease associated with myopathy, Paget disease of bone and frontotemporal dementia: review of a unique disorder

    ✓ Peer-reviewed Brain tissue and pathology Biochimica et biophysica acta

    Key finding: Approximately 90% of the affected persons in the study have myopathy or muscle weakness particularly of the shoulder and hip girdles, which can lead to loss of walking ability and even death by complications of respiratory and cardiac failure. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2008-09-17

    Neurodegeneration associated with genetic defects in phospholipase A(2)

    ✓ Peer-reviewed Brain scans and imaging Neurology

    Key finding: Defects in phospholipase A(2) lead to a range of phenotypes. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2008-09-15

    Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: a randomized controlled study

    ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society

    Key finding: OSA may aggravate cognitive dysfunction in dementia and thus may be a reversible cause of cognitive loss in patients with AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2008-09-12

    Beta-amyloid deposition and functional impairment in the retina of the APPswe/PS1DeltaE9 transgenic mouse model of Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Investigative ophthalmology & visual science

    Key finding: The present findings suggest that Abeta deposition disrupts retinal structure and may contribute to the visual deficits seen in aged APPswe/PS1DeltaE9 tg mice. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2008-09-12

    Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation

    ✓ Peer-reviewed TREM2 and immune genetics Brain

    Triggering receptor expressed on myeloid cells 2 (TREM-2) is a membrane-bound receptor expressed by microglia and macrophages.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →