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Disrupted olfactory functional connectivity in patients with late-life depression
Mingfeng Yang, Ben Chen, Xiaomei Zhong, Huarong Zhou, Naikeng Mai, Min Zhang, Zhangying Wu, Qi Peng et al.. Journal of affective disorders, 2022-03-13
Topic: Brain imaging, connectivity and assessment
Compared with LLD patients without OI impairment and normal controls, LLD patients with OI impairment exhibited increased FC between the left orbital frontal cortex (OFC) and left calcarine gyrus, between the left OFC and right lingual gyrus, between the right OFC and right rectus gyrus, and decreased FC between the right piriform cortex and right superior parietal lobule. Additionally, these abnormal FCs were associated with scores of OI, global cognition and language function. Finally, the FC between the right piriform cortex and right superior parietal lobule exhibited a partially mediated effect on the relationship between OI and MMSE scores. LIMITATIONS: The present study did not exclude the possible effect of drugs. LLD patients with OI impairment exhibited more disrupted olfactory FC (a decrease in the primary olfactory cortex and an increase in the secondary olfactory cortex) than LLD patients with intact OI, and these abnormal FCs may serve as potential targets for neuromodulation in LLD patients to prevent them from developing dementia.
Key findings
- Compared with LLD patients without OI impairment and normal controls, LLD patients with OI impairment exhibited increased FC between the left orbital frontal cortex (OFC) and left calcarine gyrus, between the left OFC and right lingual gyrus, between the right OFC and right rectus gyrus, and decreased FC between the right piriform cortex and right superior parietal lobule.
- Additionally, these abnormal FCs were associated with scores of OI, global cognition and language function.
- Finally, the FC between the right piriform cortex and right superior parietal lobule exhibited a partially mediated effect on the relationship between OI and MMSE scores.
- LIMITATIONS: The present study did not exclude the possible effect of drugs.
- LLD patients with OI impairment exhibited more disrupted olfactory FC (a decrease in the primary olfactory cortex and an increase in the secondary olfactory cortex) than LLD patients with intact OI, and these abnormal FCs may serve as potential targets for neuromodulation in LLD patients to prevent them from developing dementia.
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Study details
- Participants150
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 28 of the 56 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of affective disorders) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 150 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35292309) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 28 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 28 of the 56 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
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APA 7th
Yang, M., Chen, B., Zhong, X., Zhou, H., Mai, N., Zhang, M., et al. (2022). Disrupted olfactory functional connectivity in patients with late-life depression. Journal of affective disorders. https://doi.org/10.1016/j.jad.2022.03.014
Vancouver
Yang M, Chen B, Zhong X, Zhou H, Mai N, Zhang M, et al. Disrupted olfactory functional connectivity in patients with late-life depression. Journal of affective disorders. 2022. doi:10.1016/j.jad.2022.03.014. PMID: 35292309.
BibTeX
@article{yang2022-35292309,
author = {Yang, Mingfeng and Chen, Ben and Zhong, Xiaomei and Zhou, Huarong and Mai, Naikeng and Zhang, Min and Wu, Zhangying and Peng, Qi and others},
title = {{Disrupted olfactory functional connectivity in patients with late-life depression}},
journal = {Journal of affective disorders},
year = {2022},
doi = {10.1016/j.jad.2022.03.014},
pmid = {35292309},
url = {https://doi.org/10.1016/j.jad.2022.03.014}
}