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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 8,451–8,475 of 27,380 studies, newest first · page 339 of 1096.

September 2022 25

  1. 2022-09-23

    Clinical performance and robustness evaluation of plasma amyloid-β42/40 prescreening

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Elecsys plasma Aβ42 /Aβ40 could potentially rule out amyloid pathology in populations with low-to-moderate amyloid positivity prevalence. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2022-09-23

    The effects of aerobic exercise and transcranial direct current stimulation on cognitive function in older adults with and without cognitive impairment: A systematic review and meta-analysis

    ✓ Peer-reviewed Prevention trials Ageing research reviews

    Key finding: Overall, 68 studies were included in the meta-analyses. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2022-09-23

    Sum of boxes of the clinical dementia rating scale highly predicts conversion or reversion in predementia stages

    ✓ Peer-reviewed Digital health tools Frontiers in aging neuroscience

    Key finding: Conversion rates increased with increasing CDR-SB scores. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2022-09-23

    Development of a novel dementia risk prediction model in the general population: A large, longitudinal, population-based machine-learning study

    ✓ Peer-reviewed Digital health tools EClinicalMedicine

    Key finding: Our prediction model was internally evaluated based on five-fold cross-validation on discrimination and calibration, and it was further compared with existing prediction scales. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2022-09-22

    Imaging of the optic nerve: technological advances and future prospects

    ✓ Peer-reviewed Brain scans and imaging The Lancet. Neurology

    Key finding: For example, optic nerve imaging with optical coherence tomography (OCT) is now widely used as an outcome measure in clinical trials of neurological disorders (eg, demyelinating diseases), and OCT findings could be informative of disease progression in patients with various neurodegenerative disorders (eg, Alzheimer's disease or Parkinson's disease). +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2022-09-22

    Temporal order of clinical and biomarker changes in familial frontotemporal dementia

    ✓ Peer-reviewed Biomarkers Nature medicine

    Key finding: We found that the temporal ordering of clinical and biomarker progression differed by genotype.

    Full summary, score breakdown and related studies → Original source

  7. 2022-09-22

    Essential metals in health and disease

    ✓ Peer-reviewed Risk factors Chemico-biological interactions

    Key finding: The catalytic behaviour of redox metals which have escaped control, e.g. via the Fenton reaction, results in the formation of reactive hydroxyl radicals, which may cause damage to DNA, proteins and membranes. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2022-09-22

    Metabolomic profiles predict individual multidisease outcomes

    ✓ Peer-reviewed Prevention and risk Nature medicine

    Key finding: We found metabolomic states to be associated with incident event rates in all the investigated conditions, except breast cancer. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2022-09-22

    The RSNA QIBA Profile for Amyloid PET as an Imaging Biomarker for Cerebral Amyloid Quantification

    ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    Key finding: On achieving conformance, sites can justify a claim that brain amyloid burden reflected by the SUVR is measurable to a within-subject coefficient of variation of no more than 1.94% when the same radiopharmaceutical, scanner, acquisition, and analysis protocols are used. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2022-09-21

    The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer's Disease Mouse Model

    ✓ Peer-reviewed Disease mechanisms Brain sciences

    Key finding: Cognitive function, measured through an object recognition task, showed non-significant improvement after TLTC. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2022-09-21

    Common human genetic variants of APOE impact murine COVID-19 mortality

    ✓ Peer-reviewed Genetics Nature

    Key finding: Genetic association studies have suggested that genetic variants contribute to the heterogeneity of COVID-19 outcomes, but the underlying potential causal mechanisms are insufficiently understood. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2022-09-21

    Relationship of serum beta-synuclein with blood biomarkers and brain atrophy

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Serum beta-synuclein changes differ from those of NfL and p-tau181 and are strongly related to AD, most likely reflecting temporal synaptic degeneration. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2022-09-21

    The efficacy and safety of transcutaneous auricular vagus nerve stimulation in patients with mild cognitive impairment: A double blinded randomized clinical trial

    ✓ Peer-reviewed Cognitive tests and assessment Brain stimulation

    Key finding: There are 9.9 million new cases of dementia in the world every year. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2022-09-21

    β-Amyloid, Tau, Neurodegeneration Classification and Eligibility for Anti-amyloid Treatment in a Memory Clinic Population

    ✓ Peer-reviewed Drug development Neurology

    Key finding: ATN (β-amyloid [Aβ], tau, neurodegeneration) system categorizes individuals based on their core Alzheimer disease (AD) biomarkers. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2022-09-21

    Hypertension, Neurovascular Dysfunction, and Cognitive Impairment

    ✓ Peer-reviewed Risk factors Hypertension (Dallas, Tex. : 1979)

    Key finding: Hypertension affects a significant proportion of the adult and aging population and represents an important risk factor for vascular cognitive impairment and late-life dementia. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2022-09-20

    Predictors of response to acetylcholinesterase inhibitors in dementia: A systematic review

    ✓ Peer-reviewed Treatments Frontiers in neuroscience

    Key finding: We identified 1,994 records in five different databases; after exclusion of duplicates, title and abstract screening, and full-text retrieval, 122 studies were finally included. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2022-09-20

    Comparing clinical trial population representativeness to real-world populations: an external validity analysis encompassing 43 895 trials and 5 685 738 individuals across 989 unique drugs and 286 conditions in England

    ✓ Peer-reviewed Clinical safety The lancet. Healthy longevity

    Key finding: Poor external validity can result in inadequate treatment decision information. +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2022-09-20

    Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models

    ✓ Peer-reviewed TREM2 and immune genetics Nature aging

    Key finding: By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in Tau P301S synapse fractions with age and in a C1q-dependent manner. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2022-09-19

    Antiplatelets and Vascular Dementia: A Systematic Review

    ✓ Peer-reviewed Vascular contributions Journal of aging research

    Key finding: Repeated stroke is related to an increased chance of cognitive decline, and poststroke dementia is connected with an increased risk of death.

    Full summary, score breakdown and related studies → Original source

  20. 2022-09-19

    Genetics, Functions, and Clinical Impact of Presenilin-1 (PSEN1) Gene

    ✓ Peer-reviewed Risk factors International journal of molecular sciences

    Key finding: Several motifs and residues have been identified in PSEN1, which may play a significant role in γ-secretase mechanisms, such as the WNF, GxGD, and PALP motifs. +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2022-09-16

    Distinct neurotoxic TDP-43 fibril polymorphs are generated by heterotypic interactions with α-Synuclein

    ✓ Peer-reviewed Brain tissue and pathology The Journal of biological chemistry

    Key finding: These findings establish the existence of heterotypic amyloid and provide a molecular basis for the observed overlap between synucleinopathies and TDP-43 proteinopathies.

    Full summary, score breakdown and related studies → Original source

  22. 2022-09-16

    TREM2 risk variants are associated with atypical Alzheimer's disease

    ✓ Peer-reviewed TREM2 and immune genetics Acta neuropathologica

    Key finding: Rare TREM2 variants confer significantly increased risk for clinical AD in addition to other neurodegenerative disease clinical phenotypes. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2022-09-16

    Plasma microRNAs as potential biomarkers in early Alzheimer disease expression

    ✓ Peer-reviewed Tau biomarkers Scientific reports

    Key finding: Alzheimer Disease (AD) requires new biomarkers in minimally invasive samples that allow an early diagnosis. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2022-09-15

    CSF Aβ40 and P-Tau181 Might Differentiate Atypical from Typical AD Phenotypes: Preliminary Evidence

    ✓ Peer-reviewed Biomarkers Neuro-degenerative diseases

    Key finding: Atypical and typical AD patients were comparable for Aβ42/40 values. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2022-09-15

    CRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Translational neurodegeneration

    Key finding: These results suggest that the targeted methylation of APP via dCas9-Dnmt3a treatment can be a potential therapeutic strategy for AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →