Newest studies

Signal pathways in the treatment of Alzheimer's disease with traditional Chinese medicine

41/100 ✓ Peer-reviewed Disease mechanisms Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Key finding: TCM could modulate signal pathways related to AD pathological progression, including NF-κB, Nrf2, JAK/STAT, ubiquitin-proteasome pathway, autophagy-lysosome pathway-related AMPK/mTOR, GSK-3/mTOR, and PI3K/Akt/mTOR, as well as SIRT1 and PPARα pathway. +3 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Vortioxetine Treatment for Depression in Alzheimer's Disease: A Randomized, Double-blind, Placebo-controlled Study

54/100 ✓ Peer-reviewed Clinical trials Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

Key finding: There was no statistically significant difference between the two groups in terms of depressive symptoms, cognitive functions, and ADL. +4 more findings

• Clinical Trials
• Treatments

Full summary, score breakdown and related studies → Original source

Association of Medicare bundled payment model with joint replacement care for people with dementia

70/100 ✓ Peer-reviewed Costs and economics Journal of the American Geriatrics Society

Key finding: Our sample included 3,361,950 Medicare enrollees with ADRD (2,156,995 women [64%]; mean [SD] age, 83 [8.0] years; 2,646,405 white [78%], 344,478 black [10%], 224,010 Hispanic [7%]). +4 more findings

• Policy

Full summary, score breakdown and related studies → Original source

Favorably against the odds - autophagy control despite advanced amyloid- ß toxicity

41/100 ✓ Peer-reviewed Disease mechanisms Autophagy reports

Key finding: Alzheimer disease (AD) is a devastating condition associated with loss of proteostasis control and autophagy failure, leading to progressive neuronal cell death. +2 more findings

• Side Effects

Full summary, score breakdown and related studies → Original source

Diagnostic, Prognostic, and Mechanistic Biomarkers of Diabetes Mellitus-Associated Cognitive Decline

43/100 ✓ Peer-reviewed Disease mechanisms International journal of molecular sciences

Key finding: Aging, poor glycemic control, hypoglycemia and hyperglycemic episodes, depression, and vascular complications are associated with increased risk of dementia.

• Risk Factors
• Brain Biology
• Diagnosis

Full summary, score breakdown and related studies → Original source

Population-based blood screening for pre-clinical Alzheimer’s disease: a British birth cohort at age 70

57/100 ✓ Peer-reviewed Biomarkers Journal of Neurology Neurosurgery & Psychiatry

Key finding: LC-MS Aβ1–42/1–40 performed significantly better (0.817; 0.770–0.864), with a Youden’s index cut-point of 0.095 detecting amyloid PET-positivity with 86.6% sensitivity and 71.9% specificity.

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Automated Detection of Speech Timing Alterations in Autopsy-Confirmed Nonfluent/Agrammatic Variant Primary Progressive Aphasia

63/100 ✓ Peer-reviewed Digital health tools Neurology

Key finding: We evaluated 22 persons with nfvPPA (mean age: 67.3 years; 13 female patients) and confirmed underlying 4-repeat tauopathy, 15 persons with semantic variant primary progressive aphasia (svPPA; mean age: 66.5 years; 8 female patients), and 10 healthy controls (HCs; 70 years; 5 female patients). +2 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Performance of plasma phosphorylated tau 181 and 217 in the community

63/100 ✓ Peer-reviewed Tau biomarkers Nature Medicine

Key finding: Continuous, unadjusted plasma P-tau181 and P-tau217 predicted abnormal amyloid positron-emission tomography (PET) (area under the receiver operating characteristic curve (AUROC) = 0.81-0.86) and tau PET entorhinal cortex (AUROC > 0.80), but was less predictive of a tau PET temporal region of interest (AUROC < 0.70). +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Association of Nonalcoholic Fatty Liver Disease and Fibrosis With Incident Dementia and Cognition: The Rotterdam Study

67/100 ✓ Peer-reviewed Long-term cohort studies Neurology

Key finding: Whether this results in an increased risk for dementia remains unclear. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk

56/100 ✓ Peer-reviewed Tau biomarkers PloS one

Key finding: Specifically, the participants heterozygous for this variant (KL-SVHET+) showed lower risk of developing AD. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Functional and Phenotypic Diversity of Microglia: Implication for Microglia-Based Therapies for Alzheimer's Disease

43/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in aging neuroscience

Key finding: Apart from Aβ and NFT pathologies, AD patients also exhibit a widespread microglial activation in various brain regions with elevated production of pro-inflammatory cytokines, a phenomenon known as neuroinflammation. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Modeling Down syndrome neurodevelopment with isogenic cerebral organoids

16/100 ⚠ Preprint — not yet peer-reviewed Down syndrome and Alzheimer's bioRxiv

Key finding: Initially pools of organoids from a trisomic versus disomic line found broad transcriptomic differences and modest differences in cell-type representation, suggesting a potential neurodevelopmental phenotype due to Trisomy 21. +3 more findings

• Down Syndrome
• Brain Biology

Scored 18 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

CSF phosphorylated tau as an indicator of subsequent tau accumulation

52/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging

Key finding: Higher CSF p-tau181, lower CSF Aβ42, and higher amyloid PET levels were associated with faster rates of tau PET change in both the temporal meta-ROI and ERC. +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

A Pragmatic, Data-Driven Method to Determine Cutoffs for CSF Biomarkers of Alzheimer Disease Based on Validation Against PET Imaging

58/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: The proposed novel, pragmatic method to determine CSF biomarker cutoffs for AD does not require assessment of other biomarkers or assumptions concerning the clinical diagnosis of patients.

• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

The Role of Microbiome in Brain Development and Neurodegenerative Diseases

41/100 ✓ Peer-reviewed Disease mechanisms Molecules (Basel, Switzerland)

Key finding: In addition, in the coming years, boron reagents will play a significant role to improve dysbiosis and will open new areas for researchers.

• Lifestyle

Full summary, score breakdown and related studies → Original source

From Dementia to Eumentia: A New Approach to Dementia Prevention

41/100 ✓ Peer-reviewed Prevention trials Neuroepidemiology

Key finding: Since environmental, socioeconomic, and individual risk factors contribute to dementia, we proposed a Comprehensive, Customized, Cost-effective APProach (the CCC-APP) implemented in actionable units with the focus on promoting brain health (eumentia). +4 more findings

• Prevention

Full summary, score breakdown and related studies → Original source

An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases

43/100 ✓ Peer-reviewed Inflammation and the immune system International journal of molecular sciences

Key finding: This review intends to summarize some of the findings that correlate the overproduction of reactive oxygen species with the pathophysiology of Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. +4 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Tau biomarkers in Alzheimer's disease: towards implementation in clinical practice and trials

60/100 ✓ Peer-reviewed Getting a diagnosis The Lancet. Neurology

Key finding: Neuroimaging and biofluid tau markers hold potential for optimising such clinical trials by augmenting participant selection, providing evidence of target engagement, and monitoring treatment efficacy. +4 more findings

• Clinical Trials
• Biomarkers

Full summary, score breakdown and related studies → Original source

Genome-wide association study of occupational attainment as a proxy for cognitive reserve

50/100 ✓ Peer-reviewed Risk factors Brain : a journal of neurology

Key finding: Previous genome-wide association studies have identified numerous genetic variants and revealed the genetic architecture of educational attainment, another marker of cognitive reserve. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Therapeutic Approach to Alzheimer's Disease: Current Treatments and New Perspectives

43/100 ✓ Peer-reviewed Treatments Pharmaceutics

Key finding: Alzheimer's disease (AD) is the most common cause of dementia. +3 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Brain alterations in the early Alzheimer's continuum with amyloid-β, tau, glial and neurodegeneration CSF markers

53/100 ✓ Peer-reviewed Biomarkers Brain communications

Key finding: Higher grey matter volumes/cortical thickness and fluorodeoxyglucose uptake have been consistently found in cognitively unimpaired individuals with abnormal Alzheimer's disease biomarkers compared with those with normal biomarkers. +3 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

The Association Between Race and Place of Death Among Persons With Dementia

54/100 ✓ Peer-reviewed Disparities Journal of pain and symptom management

Key finding: The sample included 993 decedents with dementia (81.4% white; 11.0% black, 7.6% hispanic). +4 more findings

• Health Equity
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Dynamic functional connectivity patterns associated with dementia risk

41/100 ✓ Peer-reviewed Risk factors Alzheimer's research & therapy

Key finding: Associations were found between times spent in (i) a "weakly connected" state and lower self-reported engagement in early- and mid-life cognitive activity and higher LDL cholesterol; (ii) a "SN-negatively connected" state and higher blood pressure, higher depression score, and lower body mass index (BMI); (iii) a "strongly connected" state and higher self-reported engagement in early-life cognitive activity, Preclinical Alzheimer's cognitive composite-5 score, and BMI; and (iv) a "DMN-negatively connected" state and higher self-reported engagement in early- and mid-life stimulating activities and lower LDL cholesterol and blood pressure. +2 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Vision Impairment and Patient Activation among Medicare Beneficiaries

64/100 ✓ Peer-reviewed Risk factors Ophthalmic epidemiology

Key finding: In total, 6,683 participants were included. +4 more findings

• Policy

Full summary, score breakdown and related studies → Original source

A Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's Disease

41/100 ✓ Peer-reviewed Genetics Frontiers in aging neuroscience

Key finding: Mitophagy is selective autophagy through the clearance of aberrant mitochondria, specifically for degradation to maintain energy generation and neuronal and synaptic function in the brain. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source