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Diagnostic Accuracy of Blood-Based Biomarker Panels: A Systematic Review
Anette Hardy-Sosa, Karen León-Arcia, Jorge J Llibre-Guerra, Jorge Berlanga-Acosta, Saiyet de la C Baez, Gerardo Guillen-Nieto, Pedro A Valdes-Sosa. Frontiers in aging neuroscience, 2022-03-11
Topic: Plasma and spinal-fluid biomarkers
Seventy-six articles met the inclusion criteria for systematic review. Majority of the studies reported plasma and serum as the main source for biomarker determination in blood. Protein-based biomarker panels were reported to aid in AD diagnosis and prognosis with better accuracy than individual biomarkers. Conventional (amyloid-beta and tau) and neuroinflammatory biomarkers, such as amyloid beta-42, amyloid beta-40, total tau, phosphorylated tau-181, and other tau isoforms, were the most represented. We found the combination of amyloid beta-42/amyloid beta-40 ratio and APOEε4 status to be most represented with high accuracy for predicting amyloid beta-positron emission tomography status. Assessment of Alzheimer's disease biomarkers in blood as a non-invasive and cost-effective alternative will potentially contribute to early diagnosis and improvement of therapeutic interventions. Given the heterogeneous nature of AD, combination of markers seems to perform better in the diagnosis and prognosis of the disease than individual biomarkers.
Key findings
- Seventy-six articles met the inclusion criteria for systematic review.
- Majority of the studies reported plasma and serum as the main source for biomarker determination in blood.
- Protein-based biomarker panels were reported to aid in AD diagnosis and prognosis with better accuracy than individual biomarkers.
- Conventional (amyloid-beta and tau) and neuroinflammatory biomarkers, such as amyloid beta-42, amyloid beta-40, total tau, phosphorylated tau-181, and other tau isoforms, were the most represented.
- We found the combination of amyloid beta-42/amyloid beta-40 ratio and APOEε4 status to be most represented with high accuracy for predicting amyloid beta-positron emission tomography status.
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Study details
- Study designsystematic review
- Evidence strengthHigh
How this study scored 70/100
Published in a peer-reviewed journal, and it is a systematic review of all the studies on the question. Scored zero for sample size, effect reported and studied in people because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 39 of the 56 points we could judge it on, which is 70 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in aging neuroscience) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 12 / 12 | A systematic review of all the studies on the question |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35360215) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 39 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 39 of the 56 points we could judge it on is 70 out of 100. |
| Total | 70 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Hardy-Sosa, A., León-Arcia, K., Llibre-Guerra, J. J., Berlanga-Acosta, J., Baez, S. d. l. C., Guillen-Nieto, G., et al. (2022). Diagnostic Accuracy of Blood-Based Biomarker Panels: A Systematic Review. Frontiers in aging neuroscience. https://doi.org/10.3389/fnagi.2022.683689
Vancouver
Hardy-Sosa A, León-Arcia K, Llibre-Guerra JJ, Berlanga-Acosta J, Baez SdlC, Guillen-Nieto G, et al. Diagnostic Accuracy of Blood-Based Biomarker Panels: A Systematic Review. Frontiers in aging neuroscience. 2022. doi:10.3389/fnagi.2022.683689. PMID: 35360215.
BibTeX
@article{hardysosa2022-35360215,
author = {Hardy-Sosa, Anette and León-Arcia, Karen and Llibre-Guerra, Jorge J and Berlanga-Acosta, Jorge and Baez, Saiyet de la C and Guillen-Nieto, Gerardo and Valdes-Sosa, Pedro A},
title = {{Diagnostic Accuracy of Blood-Based Biomarker Panels: A Systematic Review}},
journal = {Frontiers in aging neuroscience},
year = {2022},
doi = {10.3389/fnagi.2022.683689},
pmid = {35360215},
url = {https://doi.org/10.3389/fnagi.2022.683689}
}