Newest studies

Sleep, physical activity, sedentary behavior, and risk of incident dementia: a prospective cohort study of 431,924 UK Biobank participants

60/100 ✓ Peer-reviewed Long-term cohort studies Molecular psychiatry

Key finding: This study aimed to investigate independent and joint associations of these three modifiable behaviors with dementia risks. +3 more findings

• Lifestyle
• Risk Factors

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Exploring the Impact of TREM2 in Tumor-Associated Macrophages

44/100 ✓ Peer-reviewed TREM2 and immune genetics Vaccines

Key finding: TREM2 is a transmembrane receptor of the immunoglobulin superfamily expressed in myeloid cells. +3 more findings

• Genetics

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New Insights into Neuroinflammation Involved in Pathogenic Mechanism of Alzheimer's Disease and Its Potential for Therapeutic Intervention

47/100 ✓ Peer-reviewed TREM2 and immune genetics Cells

Key finding: The exact pathogenic mechanisms of AD remain elusive, resulting in the fact that the current therapeutics solely focus on symptomatic management instead of preventative or curative strategies. +3 more findings

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The Impact of Type 2 Diabetes in Parkinson's Disease

55/100 ✓ Peer-reviewed Mild cognitive impairment Movement disorders : official journal of the Movement Disorder Society

Key finding: Because it is a potentially modifiable metabolic state, with multiple peripheral and central targets for intervention, it may represent a target for alleviating parkinsonian symptoms and slowing progression to disability and dementia. © 2022 The Authors. +1 more finding

• Risk Factors
• Other Dementias

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Plasma biomarkers for prognosis of cognitive decline in patients with mild cognitive impairment

62/100 ✓ Peer-reviewed Biomarkers Brain communications

Key finding: Although recent studies have demonstrated the prognostic utility of plasma biomarkers of Alzheimer pathology or neurodegeneration, such as pTau-181 and NF-L, whether other plasma biomarkers can further improve prediction of cognitive decline is undetermined. +4 more findings

• Biomarkers
• Early Stage

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Evidence of beta amyloid independent small vessel disease in familial Alzheimer's disease

41/100 ✓ Peer-reviewed Risk genes beyond APOE Brain pathology (Zurich, Switzerland)

Key finding: Furthermore, we found significantly enlarged perivascular spaces in vessels devoid of cerebral amyloid angiopathy in FAD compared with SAD and CADASIL subjects. +1 more finding

• Genetics
• Brain Scans
• Other Dementias

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Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts

72/100 ✓ Peer-reviewed Disease mechanisms Acta neuropathologica

Key finding: Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) and Alzheimer's disease neuropathologic change (ADNC) are each associated with substantial cognitive impairment in aging populations. +1 more finding

• Brain Biology

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Investigating Heterogeneity and Neuroanatomic Correlates of Longitudinal Clinical Decline in Atypical Alzheimer Disease

54/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Longitudinal patterns of clinical decline differ between LPA and PCA but are heterogeneous and related to different patterns of topographic spread. +4 more findings

• Brain Scans

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Cannabis in Palliative Care: A Systematic Review of Current Evidence

78/100 ✓ Peer-reviewed End-of-life care Journal of pain and symptom management

Key finding: Fifty-two studies (20 randomised; 32 non-randomised) with 4786 participants diagnosed with cancer (n = 4491), dementia (n = 43), AIDS (n = 235), spasticity (n = 16), NORSE syndrome (n = 1) were included.

• End-of-Life Care

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Effect of cerebellum stimulation on cognitive recovery in patients with Alzheimer disease: A randomized clinical trial

61/100 ✓ Peer-reviewed Treatments Brain stimulation

Key finding: Our results depict that 5 Hz rTMS of the bilateral cerebellum is a promising, non-invasive treatment of cognitive dysfunction in AD patients. +3 more findings

• Clinical Trials

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Social Isolation and Incident Dementia in the Oldest-Old-A Competing Risk Analysis

71/100 ✓ Peer-reviewed Risk factors Frontiers in psychiatry

Key finding: Excluding participants with prevalent dementia, n = 1,161 individuals were included. +4 more findings

• Risk Factors
• Lifestyle

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Bulk and Single-Nucleus Transcriptomics Highlight Intra-Telencephalic and Somatostatin Neurons in Alzheimer's Disease

55/100 ✓ Peer-reviewed Genetics Frontiers in molecular neuroscience

Key finding: Here, we analyzed cell subtype proportion differences in AD compared to non-AD controls using 1037 post-mortem brain samples from six neocortical regions. +3 more findings

• Brain Biology

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Innate Immune Cell Death in Neuroinflammation and Alzheimer's Disease

43/100 ✓ Peer-reviewed End-of-life care Cells

Key finding: Multiple studies have shown that many of the brain's immunological cells, specifically microglia and astrocytes, are involved in AD pathogenesis. +2 more findings

• Brain Biology

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DYRK1A and Activity-Dependent Neuroprotective Protein Comparative Diagnosis Interest in Cerebrospinal Fluid and Plasma in the Context of Alzheimer-Related Cognitive Impairment in Down Syndrome Patients

43/100 ✓ Peer-reviewed Biomarkers Biomedicines

Key finding: Down syndrome (DS) is a complex genetic condition due to an additional copy of human chromosome 21, which results in the deregulation of many genes. +4 more findings

• Biomarkers
• Down Syndrome

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Fear of Incompetence in Family Caregivers and Dementia Care Transitions

50/100 ✓ Peer-reviewed Caregiving International journal of aging & human development

Key finding: Research on interpersonal interaction dynamics in relationships between persons with dementia and their family caregivers has been limited. +4 more findings

• Caregiving

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Longitudinal evaluation of neuroinflammation and oxidative stress in a mouse model of Alzheimer disease using positron emission tomography

49/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: TSPO and x c - overexpression can be assessed by [ 18 F]DPA-714 and [ 18 F]FSPG, respectively, and correlate with the level of Aβ plaque deposition obtained with a PET amyloid tracer. +4 more findings

• Brain Biology
• Brain Scans

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The application of technology to improve cognition in older adults: A review and suggestions for future directions

71/100 ✓ Peer-reviewed Cognitive tests and assessment PsyCh journal

Key finding: The rapidly increasing worldwide population of older adults, along with the increasing prevalence of cognitive impairment and dementia in this population, is a growing health-care problem. +4 more findings

• Digital Tools

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Pain Impacting Quality of Life in Persons with Dementia Dying in the Nursing Home by Alternative Medicare Payment Model

46/100 ✓ Peer-reviewed Health systems and care delivery Journal of Palliative Medicine

Key finding: There were 115,757 NH residents with dementia who self-reported pain in the last 30 days of life. +4 more findings

• Care Services
• End-of-Life Care
• Policy

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Lipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progression

47/100 ✓ Peer-reviewed TREM2 and immune genetics Oncoimmunology

Key finding: Macrophages are the most abundant immune cell type within TAME, although their diversity in the TAME is not clear. +3 more findings

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Associations Between Sleep Duration and Sensory Impairments Among Older Adults in China

55/100 ✓ Peer-reviewed Risk factors Frontiers in aging neuroscience

Key finding: Of the 17,668 respondents, 8,396 (47.5%) were men. +4 more findings

• Lifestyle

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Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) R47H Variant Causes Distinct Age- and Sex-Dependent Musculoskeletal Alterations in Mice

41/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Key finding: Male TREM2R47H/+ animals had decreased trabecular bone geometry but increased ultimate strain and failure force at 20 months of age versus WT. +3 more findings

• Genetics
• Brain Biology

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Cyanidin-3-O-Glucoside Regulates the M1/M2 Polarization of Microglia via PPARγ and Aβ42 Phagocytosis Through TREM2 in an Alzheimer's Disease Model

44/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurobiology

Key finding: Cyanidin-3-O-glucoside (C3G), a dietary anthocyanin found in many fruits and vegetables, has been reported as an antioxidant, anti-inflammatory, and antitumor agent. +3 more findings

• Genetics
• Brain Biology

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Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model

47/100 ✓ Peer-reviewed TREM2 and immune genetics The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: We report that selective loss of Tsc1 , a negative regulator of mTOR, in microglia in mice of both sexes, caused mTOR activation and upregulation of Trem2 with enhanced β-Amyloid (Aβ) clearance, reduced spine loss, and improved cognitive function in the 5XFAD AD mouse model. +3 more findings

• Brain Biology
• Genetics

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Accelerated epigenetic aging in newborns with Down syndrome

41/100 ✓ Peer-reviewed Genetics Aging cell

Key finding: Targeted sequencing of GATA1 was performed in a subset of 184 newborns with DS to identify somatic mutations associated with transient abnormal myelopoiesis. +3 more findings

• Genetics
• Down Syndrome

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A multi-hit hypothesis for an APOE4-dependent pathophysiological state

41/100 ✓ Peer-reviewed Genetics The European journal of neuroscience

Key finding: The APOE gene encoding the Apolipoprotein E protein is the single most significant genetic risk factor for late-onset Alzheimer's disease. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source