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CPNP 2022 Annual Meeting Poster Abstracts
Mental Health Clinician, 2022-04-01
Topic: Risk, prevention and care in population studies
A total of 11 case reports met criteria for inclusion. The average patient was a 53.5-year-old female taking an SSRI with baseline and maximum QTc measurements of 420 msec and 535 msec, respectively. The three risk scoring tools agreed in 4/11 (36%) cases. For the remaining 7/11 (64%) cases the Tisdale and RISQ-PATH scores identified risk as “low” whereas the Mayo score identified risk as “high”. Only one case specified the QT correction formula utilized. The most common intervention was to stop the antidepressant (45%, 5/11). Available case reports demonstrate a lack of consistency regarding QT correction formula used, risk evaluation techniques, and clinical management strategies. The Mayo risk scoring tool was the most conservative while Tisdale was the least conservative. Future research in this area can seek to develop a standardized approach for antidepressant-associated QTc prolongation in patients.Casey M. Lee, PharmD, MAS, APh, FCCP, BCPP1,21 UC San Diego Health, San Diego, CA; 2 UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, CAType: Original Research. Of 131 patients who met inclusion criteria, 43% (n = 56) were identified as MtF, 41% (n = 54) as FtM, and 16% (n = 21) as NB. The most common concomitant diagnoses were mood disorders (n = 96, 73%) and generalized anxiety disorder (GAD) (n = 67, 51%). Approximately 37% (n = 48) of patients did not have an active antidepressant prescription at the time of GD and mood and/or anxiety disorder diagnosis. There was no significant difference in number of psychotropic prescriptions between gender identities (P = .357) or age group (P = .378). However, MtFs were prescribed bupropion at significantly higher rates than FtM and NB patients (16%, 11%, 0%, P = .046). Moreover, the prevalence of GAD was significantly greater among FtMs (P = .044) and those ≤ 40 years old (P < .001). Although there was no observable difference in the number of antidepressant prescriptions between gender or age groups, a staggering 37% of patients were not prescribed any antidepressants at time of their GD and mood and/or anxiety disorder. This serendipitous finding elucidates a potential gap in mental healthcare treatment among transgender adults. The study presents a potential opportunity for clinicians to address these health disparities faced by the highly marginalized population of transgender individuals.Carolanne Wartman, PharmD1,2; David Butterfield, PharmD1,2; Lindsey Anderson, PharmD1,2; Michael Pet
Key findings
- A total of 11 case reports met criteria for inclusion.
- The average patient was a 53.5-year-old female taking an SSRI with baseline and maximum QTc measurements of 420 msec and 535 msec, respectively.
- The three risk scoring tools agreed in 4/11 (36%) cases.
- For the remaining 7/11 (64%) cases the Tisdale and RISQ-PATH scores identified risk as “low” whereas the Mayo score identified risk as “high”.
- Only one case specified the QT correction formula utilized.
Why it matters
This study examined case reports of antidepressant-associated QTc prolongation and found inconsistent risk evaluation and management, with no standardized approach. It does not address treating, curing, or preventing Alzheimer's disease.
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Study details
- Study designcross-sectional
- Participants56
- Effect size4.6%
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for randomised / blinded because the record does not state it. We have no data on senior author's track record and institution's track record, so those were left out: it earned 36 of the 93 points we could judge it on, which is 39 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Mental Health Clinician) |
| Journal's citation record | 0 / 4 | Mental Health Clinician: journal h-index 33 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 56 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.3 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 1 / 6 | Cited 0.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 0 institution(s) in 0 countries — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Points | 36 / 93 | Scored on 18 of 20 parts. We have no data for the rest, so they are left out: 36 of the 93 points we could judge it on is 39 out of 100. |
| Total | 39 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. This record has no authors, so the citation leaves them out. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
CPNP 2022 Annual Meeting Poster Abstracts. (2022). Mental Health Clinician. https://doi.org/10.9740/mhc.2022.04.089
Vancouver
CPNP 2022 Annual Meeting Poster Abstracts. Mental Health Clinician. 2022. doi:10.9740/mhc.2022.04.089.
BibTeX
@article{study2022-9f4f564f,
title = {{CPNP 2022 Annual Meeting Poster Abstracts}},
journal = {Mental Health Clinician},
year = {2022},
doi = {10.9740/mhc.2022.04.089},
url = {https://doi.org/10.9740/mhc.2022.04.089}
}