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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 9,026–9,050 of 27,380 studies, newest first · page 362 of 1096.

March 2022 25

  1. 2022-03-28

    High lifelong cognitive reserve prolongs disability-free survival: The role of cognitive function

    ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: CR score was dose-dependently associated with disability/death (hazard ratio [HR] 0.96, 95% confidence interval [CI] 0.93-0.99). +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2022-03-28

    CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN 1 M146L mutation

    ✓ Peer-reviewed Biomarkers Molecular therapy. Nucleic acids

    Key finding: Fluorescence resonance energy transfer-based conformation and western blot analyses indicated that CRISPR-Cas9 treatment also affects the overall PS1 conformation and reduces PS1 levels. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2022-03-28

    CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease

    ✓ Peer-reviewed Tau biomarkers Neurobiology of disease

    Key finding: However, it remains unknown whether white matter (WM) decline due to AD is associated with specific Tau phosphorylation site(s). +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2022-03-28

    Integrative spatial analysis of cell morphologies and transcriptional states with MUSE

    ✓ Peer-reviewed Risk genes beyond APOE Nature biotechnology

    Key finding: Here we present multi-modal structured embedding (MUSE), an approach to characterize cells and tissue regions by integrating morphological and spatially resolved transcriptional data. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2022-03-28

    Artificial intelligence in brain MRI analysis of Alzheimer's disease over the past 12 years: A systematic review

    ✓ Peer-reviewed Digital health tools Ageing research reviews

    Key finding: The synthesized evidence is paramount to developing sophisticated AI approaches to reliably capture and quantify multiple subtle MRI changes in the whole brain that exemplify the complexity and heterogeneity of AD and brain aging. +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2022-03-28

    Cost-effectiveness of Aducanumab and Donanemab for Early Alzheimer Disease in the US

    ✓ Peer-reviewed Costs and economics JAMA Neurology

    Key finding: Modeled ICER for aducanumab was $981,000 per QALY gained (health care sector perspective) +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2022-03-27

    α-Synuclein at the Presynaptic Axon Terminal as a Double-Edged Sword

    ✓ Peer-reviewed Brain tissue and pathology Biomolecules

    Key finding: α-synuclein (α-syn) is a presynaptic, lipid-binding protein strongly associated with the neuropathology observed in Parkinson's disease (PD), dementia with Lewy bodies (DLB), and Alzheimer's Disease (AD). +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2022-03-25

    Association of Emerging β-Amyloid and Tau Pathology With Early Cognitive Changes in Clinically Normal Older Adults

    ✓ Peer-reviewed Drug development Neurology

    Key finding: We sought to identify cognitive measures associated with the earliest detectable signs of emerging Aβ and tau pathology. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2022-03-25

    Risk of first ischaemic stroke and use of antidopaminergic antiemetics: nationwide case-time-control study

    ✓ Peer-reviewed Health systems and care delivery BMJ (Clinical research ed.)

    Key finding: To estimate the risk of ischaemic stroke associated with antidopaminergic antiemetic (ADA) use. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2022-03-25

    The use of digital technologies by people with mild-to-moderate dementia during the COVID-19 pandemic: A positive technology perspective

    ✓ Peer-reviewed Digital health tools Dementia (London, England)

    Key finding: A growing body of research has shown that people with dementia are using digital technologies to enhance lived experience.

    Full summary, score breakdown and related studies → Original source

  11. 2022-03-25

    Rapid Biomarker Screening of Alzheimer's Disease by Interpretable Machine Learning and Graphene-Assisted Raman Spectroscopy

    ✓ Peer-reviewed Digital health tools ACS nano

    Key finding: Specifically, we collected Raman spectra on slices of mouse brains with and without AD and used machine learning to classify AD and non-AD spectra. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2022-03-25

    P Wave Parameters and Indices: A Critical Appraisal of Clinical Utility, Challenges, and Future Research-A Consensus Document Endorsed by the International Society of Electrocardiology and the International Society for Holter and Noninvasive Electrocardiology

    ✓ Peer-reviewed Prevention and risk Circulation. Arrhythmia and electrophysiology

    Key finding: Atrial cardiomyopathy, characterized by abnormalities in atrial structure and function, is associated with increased risk of adverse cardiovascular and neurocognitive outcomes, independent of atrial fibrillation. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2022-03-24

    Blood biomarkers for cognitive decline and clinical progression in a Mexican American cohort

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

    Key finding: Higher GFAP and NFL were associated with global cognitive decline. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2022-03-24

    P-tau217 in Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Clinica chimica acta; international journal of clinical chemistry

    Key finding: Current evidence shows that plasma p-tau217 is a sensitive maker of the clinical manifestation and progression of Alzheimer's disease and of pathological changes associated with this condition, including amyloid accumulation, tau burden, brain atrophy and physical degradation. +2 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2022-03-24

    Lesions without symptoms: understanding resilience to Alzheimer disease neuropathological changes

    ✓ Peer-reviewed Disparities Nature reviews. Neurology

    Key finding: In this Review, we begin by considering the heterogeneity of clinical manifestations associated with the presence of plaques and tangles, and then focus on insights derived from the rare yet informative individuals who display high amounts of amyloid and tau deposition in their brains (observed directly at autopsy) without manifesting dementia during life.

    Full summary, score breakdown and related studies → Original source

  16. 2022-03-24

    Effects of multisite anodal transcranial direct current stimulation combined with cognitive stimulation in patients with Alzheimer's disease and its neurophysiological correlates: A double-blind randomized clinical trial

    ✓ Peer-reviewed Treatments Neurophysiologie clinique = Clinical neurophysiology

    Key finding: Anodal tDCS+CS delays cognitive decline (ADAS-cog change) to a greater extent than sham tDCS+CS (-3.4±1.1 vs. -1.7±0.4; p=.03). +2 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2022-03-23

    Small Vessel Disease: Ancient Description, Novel Biomarkers

    ✓ Peer-reviewed Vascular contributions International journal of molecular sciences

    Key finding: Nevertheless, the arteriolosclerosis process, which underlines SVD development, is based on different mechanisms, not all completely understood, which start from a chronic hypoperfusion state and pass through a chronic brain inflammatory condition, inducing a significant endothelium activation and a consequent tissue remodeling action. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2022-03-23

    Antiviral, immunomodulatory, and neuroprotective effect of lithium

    ✓ Peer-reviewed Drug development Journal of integrative neuroscience

    Key finding: The therapeutic effects of lithium in systemic and topical administration on labial and genital herpes were demonstrated in clinical studies. +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2022-03-23

    Non-linear Character of Plasma Amyloid Beta Over the Course of Cognitive Decline in Alzheimer's Continuum

    ✓ Peer-reviewed Biomarkers Frontiers in aging neuroscience

    Key finding: Plasma amyloid-β (Aβ) was associated with brain Aβ deposition and Alzheimer's disease (AD) development. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2022-03-23

    Oxidative Stress and 4-hydroxy-2-nonenal (4-HNE): Implications in the Pathogenesis and Treatment of Aging-related Diseases

    ✓ Peer-reviewed Risk factors Journal of immunology research

    Key finding: Oxidative stress plays an important role in the development of aging-related diseases by accelerating the lipid peroxidation of polyunsaturated fatty acids in the cell membrane, resulting in the production of aldehydes, such as malondialdehyde and 4-hydroxy-2-nonenal (4-HNE) and other toxic substances. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2022-03-23

    Application of Meta-analysis to Evaluate Relationships Among ARIA-E Rate, Amyloid Reduction Rate, and Clinical Cognitive Response in Amyloid Therapeutic Clinical Trials for Early Alzheimer's Disease

    ✓ Peer-reviewed Treatments Therapeutic innovation & regulatory science

    Key finding: Aβ plaques removal in the brain due to amyloid therapy is strongly correlated with a better clinical response in patients with early Alzheimer's disease and a higher ARIA-E rate for the treatment groups and clinical trials in this meta-analysis. +1 more finding

    Full summary, score breakdown and related studies → Original source

  22. 2022-03-23

    A Longitudinal Study of Plasma pTau181 in Mild Cognitive Impairment with Lewy Bodies and Alzheimer's Disease

    ✓ Peer-reviewed Biomarkers Movement disorders : official journal of the Movement Disorder Society

    Key finding: One hundred forty-six subjects (56 probable MCI-LB, 22 possible MCI-LB, 44 MCI-AD, and 24 controls) were reviewed for up to 5.7 years. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2022-03-23

    [Diagnosing Alzheimer Dementia in People with Down Syndrome in Accordance with ICD, DSM V and A/T/N System]

    ✓ Peer-reviewed Down syndrome and Alzheimer's Fortschritte der Neurologie-Psychiatrie

    Key finding: Due to a triplication of the amyloid precursor protein (APP) gene on chromosome 21, most people with Down's Syndrome (DS) are at high risk of developing an Alzheimer type of dementia associated with Down's Syndrome (DS-AD).

    Full summary, score breakdown and related studies → Original source

  24. 2022-03-23

    Amyloid-Related Imaging Abnormalities With Anti-amyloid Antibodies for the Treatment of Dementia Due to Alzheimer's Disease

    ✓ Peer-reviewed Prevention and risk Frontiers in neurology

    Key finding: Passive immunotherapy with aducanumab (Aduhelm), lecanemab, donanemab, and gantenerumab all lower CNS amyloid (Aβ) burden but come with a significant risk of amyloid-related imaging abnormality (ARIA)-the most common side effect of this class of drugs. +2 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2022-03-21

    Personalized Management and Treatment of Alzheimer's Disease

    ✓ Peer-reviewed Risk factors Life (Basel, Switzerland)

    Key finding: Men and women show substantial differences in their AD-related phenotypes. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →