Newest studies

Cognitive screening tools for identification of dementia in illiterate and low-educated older adults, a systematic review and meta-analysis

57/100 ✓ Peer-reviewed Disparities International psychogeriatrics

Key finding: Numerous tools for assessment of cognitive impairment in low-literacy settings have been developed, and tools developed for use in high-income countries have also been validated in low-literacy settings. +1 more finding

• Diagnosis
• Health Equity

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Reduced acoustic startle response and peripheral hearing loss in the 5xFAD mouse model of Alzheimer's disease

38/100 ✓ Peer-reviewed Risk factors Genes, brain, and behavior

Key finding: Hearing dysfunction has been associated with Alzheimer's disease (AD) in humans, but there is little data on the auditory function of mouse models of AD. +2 more findings

• Brain Biology
• Risk Factors

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Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and Metabolome

41/100 ✓ Peer-reviewed Clinical safety Scientific reports

Key finding: We hypothesized that, compared to E3 mice, E4 mice would be more susceptible to the harmful cognitive effects of high fat diet (HFD)-induced IR due to apoE isoform-specific differences in brain metabolism. +2 more findings

• Genetics

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Blood cholesterol in late-life and cognitive decline: a longitudinal study of the Chinese elderly

62/100 ✓ Peer-reviewed Cognitive tests and assessment Molecular neurodegeneration

Key finding: We thus examined whether higher blood cholesterol concentrations were associated with faster cognitive decline in a community-based longitudinal study of Chinese elderly. +3 more findings

• Risk Factors

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Mild Cognitive Impairment Is Characterized by Deficient Brainstem and Cortical Representations of Speech

62/100 ✓ Peer-reviewed Digital health tools The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Previous neuroimaging studies reveal that MCI is associated with aberrant sensory-perceptual processing in cortical brain regions subserving auditory and language function. +4 more findings

• Early Stage

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Hippocampal and Amygdala Gray Matter Loss in Elderly Controls with Subtle Cognitive Decline

50/100 ✓ Peer-reviewed Brain scans and imaging Frontiers in aging neuroscience

Key finding: In contrast to the idea that hippocampal and amygdala volume loss occur in late phases of neurodegeneration, recent contributions point to the relevance of preexisting structural deficits that are associated with aging and are independent of amyloid deposition in preclinical Alzheimer disease cases. +4 more findings

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Dementia in Women

39/100 ✓ Peer-reviewed Caregiving The Psychiatric clinics of North America

Key finding: Despite the progress made in the understanding of the etiology, neuropathophysiology, and treatment of different types of dementia, such disorders continue to pose huge health problems worldwide. +3 more findings

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Connected Speech in Neurodegenerative Language Disorders: A Review

48/100 ✓ Peer-reviewed Digital health tools Frontiers in psychology

Key finding: A total of 61 studies have been included, considering only those reporting group analysis and comparisons with a group of healthy persons. +4 more findings

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Determinants of Dropout and Nonadherence in a Dementia Prevention Randomized Controlled Trial: The Prevention of Dementia by Intensive Vascular Care Trial

76/100 ✓ Peer-reviewed Prevention trials Journal of the American Geriatrics Society

Key finding: In a large dementia prevention trial with 6-year follow-up, dropout was associated with older age, poorer cognitive function, symptoms of depression, and disability at baseline. +3 more findings

• Clinical Trials
• Prevention
• Risk Factors

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SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions

43/100 ✓ Peer-reviewed Inflammation and the immune system Neuropathology : official journal of the Japanese Society of Neuropathology

Key finding: Brains of SAMP8 mice reveal an age-associated increase of PAS-positive granular structures in the hippocampal formation and astrogliosis in the brain stem and hippocampus. +3 more findings

• Brain Biology

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Cerebral microbleeds and risk of incident dementia: the Framingham Heart Study

52/100 ✓ Peer-reviewed Long-term cohort studies Neurobiology of aging

Key finding: CMB detection in asymptomatic persons may help identify those at risk for dementia and may influence preventive strategies and design of clinical trials testing treatments for dementia. +3 more findings

• Risk Factors

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Prediction and classification of Alzheimer disease based on quantification of MRI deformation

53/100 ✓ Peer-reviewed Brain scans and imaging PloS one

Key finding: The proposed method obtained accuracy of 96.5% in differentiating mild AD from healthy elderly with the whole-brain gray matter or temporal lobe as region of interest (ROI), 91.74% in differentiating progressive MCI from healthy elderly and 88.99% in classifying progressive MCI versus stable MCI with amygdala or hippocampus as ROI.

• Brain Scans

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Advance care planning for patients with amyotrophic lateral sclerosis

50/100 ✓ Peer-reviewed End-of-life care Amyotrophic lateral sclerosis & frontotemporal degeneration

Key finding: The mean concordance between patient wishes and the clinical team decisions was significantly higher post-intervention (post = 91.9%, 95% CI = 87.8, 96.1, vs. pre = 52.4%, 95% CI = 41.9, 62.9; p <0.001). +4 more findings

• End-of-Life Care

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Parkinson's Disease: From Pathogenesis to Pharmacogenomics

41/100 ✓ Peer-reviewed Risk factors International journal of molecular sciences

Key finding: Pathogenic mechanisms associated with genomic, epigenetic and environmental factors lead to conformational changes and deposits of key proteins due to abnormalities in the ubiquitin-proteasome system together with dysregulation of mitochondrial function and oxidative stress.

• Treatments
• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Role of neuroinflammation in neurodegeneration: new insights

48/100 ✓ Peer-reviewed Inflammation and the immune system Alzheimer's research & therapy

Key finding: It is now accepted that the immune privilege of the brain is not absolute, and that cells of the central nervous system are sensitive to both the inflammatory events occurring in the periphery and to the infiltration of peripheral immune cells. +3 more findings

• Brain Biology

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Costs of a Staff Communication Intervention to Reduce Dementia Behaviors in Nursing Home Care

39/100 ✓ Peer-reviewed Health systems and care delivery The journal of nursing home research sciences

Key finding: A one percentage point reduction in elderspeak costs $6.75 per staff member with average baseline elderspeak usage. +3 more findings

• Care Services
• Policy

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In Vivo cortical tau in Parkinson's disease using 18F-AV-1451 positron emission tomography

39/100 ✓ Peer-reviewed Brain scans and imaging Movement disorders : official journal of the Movement Disorder Society

Key finding: Nine PD patients (35%) were identified with mild cognitive impairment. +4 more findings

• Brain Scans
• Other Dementias

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Cognitive decline in Parkinson disease

65/100 ✓ Peer-reviewed Genetics Nature reviews. Neurology

Key finding: Several longitudinal studies have shown that MCI is a harbinger of dementia in PD, although the course is variable, and stabilization of cognition - or even reversal to normal cognition - is not uncommon. +4 more findings

• Genetics
• Early Stage
• Other Dementias

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Cerebrospinal fluid biomarker examination as a tool to discriminate behavioral variant frontotemporal dementia from primary psychiatric disorders

55/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: The best discriminators between probable/definite bvFTD and PSY were the levels of CSF NfL (area under the curve [AUC] 0.93, P < .001, 95% confidence interval [CI] 0.85-1.00), p-tau/tau ratio (AUC 0.87, P < .001, 95% CI 0.77-0.97), and YKL40 (AUC 0.82, P = .001, 95% CI 0.68-0.97). +4 more findings

• Biomarkers

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Consensus classification of posterior cortical atrophy

61/100 ✓ Peer-reviewed Lewy body dementia Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: There was strong agreement regarding the definition of the core clinico-radiological syndrome, meaning that the current consensus statement should be regarded as a refinement, development, and extension of previous single-center PCA criteria rather than any wholesale alteration or redescription of the syndrome.

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Inflammasome activation and innate immunity in Alzheimer's disease

39/100 ✓ Peer-reviewed Inflammation and the immune system Brain pathology (Zurich, Switzerland)

Key finding: Activation of innate immunity and the assembly of microglial cells at sites of Alzheimer disease pathology has long been regarded as bystander phenomenon, which does not actively contribute to disease pathogenesis and progression. +3 more findings

• Brain Biology

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Tolerability of Cholinesterase Inhibitors: A Population-Based Study of Persistence, Adherence, and Switching

55/100 ✓ Peer-reviewed Treatments Drugs & aging

Key finding: Patients on galantamine had longer mean persistence and better adherence compared with patients on donepezil, with a hazard ratio for discontinuation of 0.91 [95% confidence interval (CI) 0.87-0.96] and a relative risk for good adherence of 1.01 (95% CI 1.002-1.03). +4 more findings

• Treatments

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An early and late peak in microglial activation in Alzheimer's disease trajectory

60/100 ✓ Peer-reviewed Mild cognitive impairment Brain : a journal of neurology

Key finding: Amyloid-β deposition, neuroinflammation and tau tangle formation all play a significant role in Alzheimer's disease. +4 more findings

• Brain Biology

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Benzodiazepine Use and Risk of Developing Alzheimer's Disease: A Case-Control Study Based on Swiss Claims Data

52/100 ✓ Peer-reviewed Digital health tools CNS drugs

Key finding: After taking into consideration a possible protopathic bias in the 2 years preceding the AD diagnosis date, benzodiazepine use was not associated with an increased risk of developing AD. +3 more findings

• Treatments
• Side Effects
• Risk Factors

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Associations between specific autoimmune diseases and subsequent dementia: retrospective record-linkage cohort study, UK

62/100 ✓ Peer-reviewed Digital health tools Journal of epidemiology and community health

Key finding: The associations with vascular dementia may be one component of a broader association between autoimmune diseases and vascular damage. +4 more findings

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