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Epilepsy in neurodegenerative diseases
Neri S, Mastroianni G, Gardella E, Aguglia U, Rubboli G.. Epileptic disorders : international epilepsy journal with videotape, 2022-04-01
Topic: Brain proteins, microglia and lab models
Although epilepsy as a comorbidity in neurodegenerative disorders is increasingly recognized, its incidence is still underestimated and the features of epilepsy in the different neurodegenerative conditions are still poorly defined. Improved health care, resulting in increased longevity, will unavoidably lead to an increment of epilepsy cases in the elderly. Thus, it is conceivable to expect that neurologists will have to deal with these comorbid conditions to a growing extent in the future. In this seminar, we provide an updated overview of the clinical features, pathophysiological mechanisms and diagnostic and treatment approaches of epilepsy in the most common neurodegenerative disorders (such as Alzheimer disease and other types of dementia, Parkinson disease, Down syndrome, prion diseases, and progressive myoclonus epilepsies), aiming to provide a tool that can help epileptologists and neurologists in the diagnosis and management of this increasingly reported comorbidity.
Key findings
- Although epilepsy as a comorbidity in neurodegenerative disorders is increasingly recognized, its incidence is still underestimated and the features of epilepsy in the different neurodegenerative conditions are still poorly defined.
- Improved health care, resulting in increased longevity, will unavoidably lead to an increment of epilepsy cases in the elderly.
- Thus, it is conceivable to expect that neurologists will have to deal with these comorbid conditions to a growing extent in the future.
- In this seminar, we provide an updated overview of the clinical features, pathophysiological mechanisms and diagnostic and treatment approaches of epilepsy in the most common neurodegenerative disorders (such as Alzheimer disease and other types of dementia, Parkinson disease, Down syndrome, prion diseases, and progressive myoclonus epilepsies), aiming to provide a tool that can help epileptologists and neurologists in the diagnosis and management of this increasingly reported comorbidity.
Why it matters
This review covers how epilepsy occurs alongside neurodegenerative disorders including Alzheimer disease and Down syndrome, and notes that its frequency is underestimated and its features poorly defined. It is about diagnosis and management of seizures as a comorbidity, not about treating, curing or preventing Alzheimer's disease itself.
Study details
- Evidence strengthLow
How this study scored 42/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Epileptic disorders : international epilepsy journal with videotape) |
| Journal's citation record | 1 / 4 | Epileptic Disorders: journal h-index 79 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 81 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 13.5 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 4 / 6 | Cited 9.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 3 / 4 | Cited 65 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Guido Rubboli: h-index 65 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Magna Graecia University: institution h-index 323 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35596580) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 42 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Neri, S., Mastroianni, G., Gardella, E., Aguglia, U., & Rubboli, G. (2022). Epilepsy in neurodegenerative diseases. Epileptic disorders : international epilepsy journal with videotape. https://doi.org/10.1684/epd.2021.1406
Vancouver
Neri S, Mastroianni G, Gardella E, Aguglia U, Rubboli G. Epilepsy in neurodegenerative diseases. Epileptic disorders : international epilepsy journal with videotape. 2022. doi:10.1684/epd.2021.1406. PMID: 35596580.
BibTeX
@article{neri2022-35596580,
author = {Neri, S. and Mastroianni, G. and Gardella, E. and Aguglia, U. and Rubboli, G.},
title = {{Epilepsy in neurodegenerative diseases}},
journal = {Epileptic disorders : international epilepsy journal with videotape},
year = {2022},
doi = {10.1684/epd.2021.1406},
pmid = {35596580},
url = {https://doi.org/10.1684/epd.2021.1406}
}
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