Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 21,451–21,475 of 27,380 studies, newest first · page 859 of 1096.
May 2009 25
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2009-05-27
The relation between content and structure in language production: an analysis of speech errors in semantic dementia
40/100 ✓ Peer-reviewed Digital health tools Brain and language
Key finding: Relative to controls, patients were significantly more likely to (a) substitute and omit open class words, (b) substitute (but not omit) closed class words, (c) substitute incorrect complex morphological forms and (d) produce semantically and/or syntactically anomalous sentences. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-05-27
Omega-3 fatty acids and risk of dementia: the Canadian Study of Health and Aging
53/100 ✓ Peer-reviewed Genetics The American journal of clinical nutrition
Key finding: No associations between n-3 PUFAs and dementia or AD were found. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-05-26
Several factors influenced attrition in a population-based elderly cohort: neurological disorders in Central Spain Study
62/100 ✓ Peer-reviewed Disparities Journal of clinical epidemiology
Key finding: These findings on participants who are at high risk of dropout may be useful in the planning phase of future prospective studies. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-05-22
TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity
53/100 ✓ Peer-reviewed Lewy body dementia The Journal of biological chemistry
Key finding: Here, we report that, in the absence of other components, TDP-43 spontaneously forms aggregates bearing remarkable ultrastructural similarities to TDP-43 deposits in degenerating neurons of ALS and FTLD-U patients [corrected] . +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-05-21
Automated MRI measures identify individuals with mild cognitive impairment and Alzheimer's disease
54/100 ✓ Peer-reviewed Hippocampus size on brain scans Brain : a journal of neurology
Key finding: For the discrimination of mild cognitive impairment, entorhinal cortex thickness, hippocampal volume and supramarginal gyrus thickness demonstrated an area under the curve of 0.91 (specificity 94%, sensitivity 74%, positive likelihood ratio 12.12, negative likelihood ratio 0.29) for the first cohort and an area under the curve of 0.95 (specificity 91%, sensitivity 90%, positive likelihood ratio 10.0, negative likelihood ratio 0.11) for the second cohort. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-05-21
Healthcare proxies of nursing home residents with advanced dementia: decisions they confront and their satisfaction with decision-making
55/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: HCPs of NH patients with advanced dementia can most commonly expect to encounter medical decisions relating to feeding problems, infections, and pain. +4 more findings
Full summary, score breakdown and related studies → Original source
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2009-05-20
Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway
36/100 ✓ Peer-reviewed Drug development Neuroscience
Key finding: The data showed that MG induced PC12 apoptosis in accordance with the redox (glutathione (GSH) and GSH/glutathione disulfide [GSSG]) imbalance. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-05-20
Modifiers of cognitive function and brain structure in middle-aged and elderly individuals with type 2 diabetes mellitus
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Brain research
Key finding: T2DM is associated with obesity, hypertension, dyslipidemia, hypothalamic pituitary adrenocortical (HPA) axis abnormalities and inflammation, all of which have been shown to negatively impact the brain. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-05-20
Familial aggregation of parkinsonism in progressive supranuclear palsy
59/100 ✓ Peer-reviewed Long-term cohort studies Neurology
Key finding: Progressive supranuclear palsy (PSP) is a progressive neurodegenerative disorder characterized by aggregates of the microtubule-associated protein tau (MAPT). +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-05-20
Neural correlates of Alzheimer's disease and mild cognitive impairment: a systematic and quantitative meta-analysis involving 1351 patients
71/100 ✓ Peer-reviewed Mild cognitive impairment NeuroImage
Key finding: Alzheimer's disease is the most common form of dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-05-15
Defining the human hippocampus in cerebral magnetic resonance images--an overview of current segmentation protocols
36/100 ✓ Peer-reviewed Hippocampus size on brain scans NeuroImage
Key finding: Directing resources to replication studies that incorporate characteristics of the segmentation protocols presented herein may help resolve seemingly contradictory volumetric results between prior neuroimaging studies and facilitate the appropriate selection of protocols for manual or automated delineation of the hippocampus for future research purposes.
Full summary, score breakdown and related studies → Original source
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2009-05-14
Beta-amyloid, blood vessels, and brain function
47/100 ✓ Peer-reviewed Brain tissue and pathology Stroke
Key finding: Accumulating evidence suggests that the presence of brain infarction, including silent infarction, influences the course of Alzheimer disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-05-13
Review of lithium effects on brain and blood
36/100 ✓ Peer-reviewed Drug development Cell transplantation
Key finding: Recent studies revealed a mechanism that ties together these disparate effects of lithium. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-05-13
Predicting risk of dementia in older adults: The late-life dementia risk index
57/100 ✓ Peer-reviewed Prevention and risk Neurology
Key finding: The late-life dementia risk index accurately stratified older adults into those with low, moderate, and high risk of developing dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-05-13
Incidence and prediction of falls in dementia: a prospective study in older people
69/100 ✓ Peer-reviewed Prevention and risk PloS one
Key finding: The management of symptomatic orthostatic hypotension, autonomic symptoms and depression, and the encouragement of physical activity may provide the core elements for the most fruitful strategy to reduce falls in people with dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-05-12
Brain metabolic correlates of cerebrospinal fluid beta-amyloid 42 and tau in Alzheimer's disease
45/100 ✓ Peer-reviewed Tau biomarkers Dementia and geriatric cognitive disorders
Key finding: After correction for multiple comparisons, a strong positive association between CSF Abeta42 levels and glucose metabolism was identified for 2 extensive clusters located in the right temporal, prefrontal and anterior cingulate cortices. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-05-12
Early diagnosis of Alzheimer's disease using cortical thickness: impact of cognitive reserve
48/100 ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology
Key finding: Normalized thickness index at baseline differed significantly among all the four diagnosis groups (P < 0.001) and correctly distinguished Alzheimer's disease patients from healthy controls with an 85% cross-validated accuracy. +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-05-07
Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype
47/100 ✓ Peer-reviewed Mild cognitive impairment Dementia and geriatric cognitive disorders
Key finding: CSF T-tau and P-tau as well as the APOE epsilon4/epsilon4 genotype are robust predictors of AD and are also associated with a more rapid progression from MCI to AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-05-07
Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementia
44/100 ✓ Peer-reviewed Biomarkers Dementia and geriatric cognitive disorders
Key finding: In a population-based sample, increasing gliosis precedes development of Alzheimer lesions. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-05-05
Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy
36/100 ✓ Peer-reviewed Disease mechanisms Proceedings of the National Academy of Sciences of the United States of America
Key finding: Our findings indicate that the Sanfilippo syndrome type B should also be considered a tauopathy.
Full summary, score breakdown and related studies → Original source
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2009-05-05
Periodontitis is associated with cognitive impairment among older adults: analysis of NHANES-III
57/100 ✓ Peer-reviewed Risk factors Journal of neurology, neurosurgery, and psychiatry
Key finding: Further exploration of relationships between oral health and cognition is warranted. +2 more findings
Full summary, score breakdown and related studies → Original source
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2009-05-04
Longitudinal progression of Alzheimer's-like patterns of atrophy in normal older adults: the SPARE-AD index
62/100 ✓ Peer-reviewed Mild cognitive impairment Brain : a journal of neurology
Key finding: Recent literature suggests that spatial patterns of brain atrophy discriminate amongst Alzheimer's disease, mild cognitive impairment (MCI) and cognitively normal (CN) older adults with high accuracy on an individual basis, thereby offering promise that subtle brain changes can be detected during prodromal Alzheimer's disease stages. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-05-04
Purpose in life is associated with mortality among community-dwelling older persons
66/100 ✓ Peer-reviewed Disparities Psychosomatic medicine
Key finding: Greater purpose in life is associated with a reduced risk of all-cause mortality among community-dwelling older persons. +3 more findings
Full summary, score breakdown and related studies → Original source
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2009-05-03
A peptidyl-prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles
34/100 ✓ Peer-reviewed Biomarkers Neuroscience letters
Key finding: Similar results were obtained in reactive astrocytes for the combination of FKBP12 and glial fibrillary acidic protein (GFAP). +1 more finding
Full summary, score breakdown and related studies → Original source
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2009-05 month only
Metabolic links between diabetes and Alzheimer's disease
38/100 ✓ Peer-reviewed Risk factors Expert review of neurotherapeutics
Key finding: Alterations in insulin signaling, glucose and fatty acid metabolism, as well as the accumulation of oxidatively modified and glycated proteins, are associated with both diabetes and the dementias. +1 more finding
Full summary, score breakdown and related studies → Original source
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