Newest studies

Delirium after surgery: a retrospective study of predictors, complications, and screening patterns in the national surgical quality improvement program

53/100 ✓ Peer-reviewed Clinical safety EClinicalMedicine

Key finding: Delirium screening was performed exclusively in patients aged ≥75 years, accounting for 7.3% of all surgical patients. +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Seek, and you will find? Word finding in multilingual dementia

32/100 ✓ Peer-reviewed Getting a diagnosis International Journal of Bilingualism

Key finding: With one exception, the participants scored highest in their self-identified strongest language. +4 more findings

Full summary, score breakdown and related studies → Original source

Neurodegeneration onset with glucagon-like peptide-1 receptor agonists in people with type 2 diabetes: a real-world multinational cohort study

63/100 ✓ Peer-reviewed Drug development Cardiovascular diabetology

Key finding: Overall, 214,442 matched individuals initiated GLP-1 RAs or DPP4i (109,731 women, mean age 58.6 years [SD 12], and mean HbA1c 7.7% [1.4]). +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Association between nicotine-dependent patients and delirium in intensive care units: a retrospective cohort study using a large clinical database

50/100 ✓ Peer-reviewed Clinical safety BMC Psychiatry

Key finding: A total of 24,043 patients were included, with 2,662 (11.07%) in the ND group. +4 more findings

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The novel sphingolipids cP1P and P1P attenuate neuroinflammation and enhance S1PR1/Akt/mTOR signaling to mitigate cognitive decline in an Alzheimer’s disease mouse model

39/100 ✓ Peer-reviewed Inflammation and the immune system Cell Communication and Signaling

Key finding: The findings demonstrate that administration of S1P analogs cP1P and P1P at 0.1 mg/kg and 1 mg/kg significantly reduced Aβ burden by inhibiting the amyloidogenic pathway and decreasing hyperphosphorylated tau protein levels in the mouse brain. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Ethanol induces neuroimmune dysregulation and soluble TREM2 generation in a human iPSC neuron, astrocyte, microglia triculture model

39/100 ✓ Peer-reviewed Inflammation and the immune system Alcohol

Key finding: After exposure to ethanol, we observed significant differential gene expression relating to innate immune pathways, inflammation, and microglial activation. +1 more finding

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Disentangling the Causal Effects of Education and Participation Bias on Alzheimer Disease Using Mendelian Randomization

50/100 ✓ Peer-reviewed Genetics Neurology Genetics

Key finding: Univariable MR analyses indicated that education and participation reduced the risk of AD. +2 more findings

Full summary, score breakdown and related studies → Original source

"I'll Take Any Kind of Training Anybody's Willing to Give Me" Long-Term Care Staff Perceptions on Dementia Training and Needs

43/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Medical Directors Association

Key finding: Training gaps in the U.S. dementia care workforce impact patient support. +2 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Rethinking neurodegeneration through a co-proteinopathy lens

43/100 ✓ Peer-reviewed Brain tissue and pathology Trends in neurosciences

Key finding: This single-protein paradigm has guided therapeutic development for decades; yet clinical outcomes remain modest. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Glial and neuronal cell-free DNA in plasma of sporadic bvFTD and late onset primary psychiatric disease patients

43/100 ✓ Peer-reviewed Biomarkers Scientific reports

Key finding: No significant differences were observed in the absolute levels of glial or neuronal cfDNA between the groups. +2 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Higher Burden of Cerebral Small Vessel Disease Is Associated With Risk of Incident Stroke in Community‐Dwelling Individuals

47/100 ✓ Peer-reviewed Vascular contributions Journal of the American Heart Association

Key finding: Among 1154 participants (46% men, mean age 70.9±8.7 years), 92 (8%) developed stroke over a median follow-up of 8.6 years (Q1-Q3: 5.1-12.5). +4 more findings

• Risk Factors
• Other Dementias

Full summary, score breakdown and related studies → Original source

Abnormal behaviors and glial responses in an animal model of tau pathology

38/100 ✓ Peer-reviewed Disease mechanisms Molecular Brain

Key finding: Glial responses are key features of AD and frontotemporal dementia, and are associated with neuroinflammation. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Restoration neurite growth by removing the blockage of endosome trafficking in Alzheimer-like mice

41/100 ✓ Peer-reviewed Disease mechanisms Neurotherapeutics

Key finding: Synaptic loss is strongly associated with cognitive decline in Alzheimer's disease (AD). +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

ADAS-Cog Trajectories Differ from Expected Decline in Dementia Following Repeated Non-Invasive Interventions over 3 Years

50/100 ✓ Peer-reviewed Cognitive tests and assessment Medicina

Key finding: Participants showed a significantly slower rate of cognitive decline than expected from the AD reference rate (p < 0.001), with many demonstrating stabilized ADAS-Cog scores during their respective treatment periods, ranging from 1 to 3 years. +4 more findings

Full summary, score breakdown and related studies → Original source

Mild cognitive impairment and neuropsychological examination

45/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in Psychology

Key finding: The paper discusses according to prevailing diagnostic systems and algorithms, which cognitive domains that are relevant to investigate, which tests that may be relevant, what kind of norms have satisfactory quality, which cut-off scores do best balance sensitivity and specificity in a neurodiagnostic context, and what kind of conclusions and recommendations that can be drawn from neuropsychological findings. +1 more finding

• Early Stage

Full summary, score breakdown and related studies → Original source

An Overview of Reviews on Telemedicine and Telehealth in Dementia Care: Mixed Methods Synthesis

57/100 ✓ Peer-reviewed Caregiving JMIR Mental Health

Key finding: Ninety-one reviews provided evidence on the impact of telemedicine in dementia care. +4 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

State-of-the-Art HCI for Dementia Care: A Scoping Review of Recent Technological Advances

41/100 ✓ Peer-reviewed Caregiving Journal of dementia and Alzheimer's disease

Key finding: Dementia significantly impacts cognitive, behavioral, and functional abilities, creating challenges for both individuals and caregivers.

Full summary, score breakdown and related studies → Original source

The final year for community-dwelling older adults with dementia in an Asian setting: admissions, interventions, and caregiver burden

51/100 ✓ Peer-reviewed Caregiving The Journals of Gerontology Series A

Key finding: Nearly half (48%) of older adults experienced an inpatient admission, and nearly all (92%) experienced a potentially burdensome intervention. +4 more findings

• Caregiving
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

[News on blood biomarker-based early diagnosis of the preliminary stages of Alzheimer's dementia]

30/100 ✓ Peer-reviewed Tau biomarkers Fortschritte der Neurologie-Psychiatrie

Key finding: Blood biomarkers are less expensive, can be measured fully automatically with high throughput, are less invasive and provide faster information on specific dementia biomarkers than current methods used in routine clinical practice such as amyloid positron emission tomography (PET) or CSF examination of underlying pathological changes in Alzheimer's disease (AD) in patients with cognitive impairment. +3 more findings

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer's disease

66/100 ✓ Peer-reviewed Laboratory science Nature Neuroscience

Key finding: Experimental evidence suggests that activated microglia induce astrocyte reactivity in neurodegenerative disorders, such as Alzheimer's disease (AD). +2 more findings

• Brain Biology
• Biomarkers

Full summary, score breakdown and related studies → Original source

ScFv-h3D6 Prevents Bapineuzumab-Induced Hemorrhagic Events in the APP23 Mouse Model of Alzheimer’s Disease

16/100 ⚠ Preprint — not yet peer-reviewed Treatments Preprints.org

Key finding: The occurrence of amyloid-related imaging abnormalities (ARIA), found in clinical trials for Aβ-immunotherapy, has been related to the antibody’s effector function on glial activation by the Fc portion of the antibody. +1 more finding

• Treatments
• Brain Biology
• Brain Scans

Scored 19 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

GLP-1 and the Degenerating Brain: Exploring Mechanistic Insights and Therapeutic Potential

43/100 ✓ Peer-reviewed Drug development International journal of molecular sciences

Key finding: Glucagon-like peptide-1 (GLP-1), an incretin hormone traditionally associated with metabolic regulation, has emerged as a promising neuroprotective agent. +2 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Plasma Biomarkers and Cognitive Decline in HIV: Findings from Two U.S. Cohorts

54/100 ✓ Peer-reviewed Biomarkers TouchREVIEWS in infectious diseases

Key finding: Both studies demonstrated longitudinal associations between elevated NfL levels and poor cognitive performance, particularly in processing speed.

• Biomarkers

Full summary, score breakdown and related studies → Original source

Early Alzheimer's disease patient care pathway and health system readiness: A framework for integrated care

36/100 ✓ Peer-reviewed Health systems and care delivery Alzheimer's & dementia (New York, N. Y.)

Key finding: We developed an Early AD Patient Care Pathway as an implementation guide that includes new diagnostic and treatment modalities and addresses needs and opportunities. +4 more findings

• Care Services
• Treatments

Full summary, score breakdown and related studies → Original source

Astrocytes upregulate interleukin-15 in response to neuroinflammation during Alzheimer's disease

33/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Alzheimer s Disease

Key finding: Astrocytes are a source of IL-15 in AD, particularly near localized Aβ pathology, and neurons are poised to respond. +2 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source