Newest studies

Cognitive and behavioral effects of hearing loss

41/100 ✓ Peer-reviewed Risk factors Current opinion in otolaryngology & head and neck surgery

Key finding: Hearing loss is one of the largest modifiable risk factors for developing dementia, accounting for up to 9% of the overall modifiable risk. +1 more finding

• Risk Factors

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Alzheimer's disease cerebrospinal fluid biomarkers differentiate patients with Creutzfeldt-Jakob disease and autoimmune encephalitis

36/100 ✓ Peer-reviewed Tau biomarkers European journal of neurology

Key finding: Autoimmune encephalitis (AE) is a potentially treatable cause of rapidly progressive dementia that may mimic Creutzfeldt-Jakob disease (CJD). +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Adherence to MIND Diet, Genetic Susceptibility, and Incident Dementia in Three US Cohorts

53/100 ✓ Peer-reviewed Prevention trials Nutrients

Key finding: Higher adherence to MIND and lower GS were associated with a lower risk of dementia in MAP and WHIMS and a slower rate of cognitive decline in MAP (p < 0.05). +2 more findings

• Lifestyle
• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model

41/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neuroinflammation

Key finding: Oral treatment of the amyloid prone AD-like APPPS1 mice with spermidine reduced neurotoxic soluble Aβ and decreased AD-associated neuroinflammation. +4 more findings

• Brain Biology

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Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease

40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Cell stem cell

Key finding: Our findings provide in vivo evidence that human microglia respond to pathological tau by exhibiting dystrophic phenotypes.

• Down Syndrome
• Brain Biology

Full summary, score breakdown and related studies → Original source

Neuropsychiatric Ramifications of Severe COVID-19 and Other Severe Acute Respiratory Infections

66/100 ✓ Peer-reviewed Digital health tools JAMA psychiatry

Key finding: In this cohort study of data from 8.38 million adults (4.18 million women, 4.20 million men; mean [SD] age 49.18 [18.45] years); 16 679 (0.02%) survived a hospital admission for SARI, and 32 525 (0.03%) survived a hospital admission for COVID-19. +3 more findings

Full summary, score breakdown and related studies → Original source

Reimagining cholinergic therapy for Alzheimer's disease

43/100 ✓ Peer-reviewed Treatments Brain : a journal of neurology

Key finding: It includes a new and updated overview of the involvement of muscarinic receptors in Alzheimer's disease as well as the recent development of new and highly selective M1 muscarinic receptor agonists with disease-modifying potential. +4 more findings

• Treatments

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Association of Mediterranean Diet With Cognitive Decline Among Diverse Hispanic or Latino Adults From the Hispanic Community Health Study/Study of Latinos

76/100 ✓ Peer-reviewed Prevention trials JAMA network open

Key finding: A total of 6321 participants (mean [SE] age, 56.1 [0.18] years at visit 1; n = 4077 women [57.8%]) were included. +2 more findings

• Lifestyle
• Health Equity

Full summary, score breakdown and related studies → Original source

Applied nutritional investigation spatial variation and determinants of stunting among children aged less than 5 y in Ethiopia: A spatial and multilevel analysis of Ethiopian Demographic and Health Survey 2019

48/100 ✓ Peer-reviewed Risk factors Nutrition

Key finding: The national prevalence of stunting was 36.81% (95% CI, 35.48%-38.15%), with significant spatial variations across Ethiopia. +4 more findings

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Getting Ready for Continence Certification

25/100 ✓ Peer-reviewed Health systems and care delivery Journal of Wound Ostomy and Continence Nursing

Key finding: The most significant evidence for value added by WOC nurses was for QoL improvement and was further demonstrated through improved incontinence-specific outcomes. +2 more findings

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Covid-19 and Aging: Challenges and Opportunities

39/100 ✓ Peer-reviewed Health systems and care delivery The Journals of Gerontology Series A

Key finding: Very early in the course of the Covid-19 pandemic, it became glaringly clear that older persons were at significantly increased risk of infection, severe illness, hospitalization, intensive care and respiratory support, and death. +4 more findings

• Care Services

Full summary, score breakdown and related studies → Original source

Variation in Population Attributable Fraction of Dementia Associated With Potentially Modifiable Risk Factors by Race and Ethnicity in the US

76/100 ✓ Peer-reviewed Prevention and risk JAMA network open

Key finding: A large fraction of dementia cases in the US were associated with potentially modifiable risk factors, especially for Black and Hispanic individuals. +3 more findings

• Prevention
• Health Equity
• Risk Factors

Full summary, score breakdown and related studies → Original source

The 2022 hormone therapy position statement of The North American Menopause Society

52/100 ✓ Peer-reviewed Prevention and risk Menopause (New York, N.Y.)

Key finding: "The 2022 Hormone Therapy Position Statement of The North American Menopause Society" (NAMS) updates "The 2017 Hormone Therapy Position Statement of The North American Menopause Society" and identifies future research needs. +4 more findings

• Treatments

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Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease

67/100 ✓ Peer-reviewed Genetics JAMA neurology

Key finding: In this genetic association study, a novel variant associated with AD was identified: R251G always coinherited with ε4 on the APOE gene, which mitigates the ε4-associated AD risk. +4 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Microglia Phenotypes in Aging and Neurodegenerative Diseases

43/100 ✓ Peer-reviewed Genetics Cells

Key finding: However, there is a consensus that microglia play a biphasic role in pathological conditions, with detrimental and protective phenotypes, and the overall response of microglia and the activation of different phenotypes depends on the nature and duration of the inflammatory insult, as well as the stage of disease development.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Study protocol for the Alzheimer and music therapy study: An RCT to compare the efficacy of music therapy and physical activity on brain plasticity, depressive symptoms, and cognitive decline, in a population with and at risk for Alzheimer's disease

66/100 ✓ Peer-reviewed Treatments PloS one

Key finding: Addressing the need for rigorous longitudinal data for the effectiveness of music therapy in people with and at risk for developing AD, this trial aims to enhance knowledge regarding cost-effective interventions with potentially high clinical applicability. +4 more findings

• Treatments
• Clinical Trials
• Brain Scans

Full summary, score breakdown and related studies → Original source

Area Deprivation Index as a Surrogate of Resilience in Aging and Dementia

47/100 ✓ Peer-reviewed Risk factors Frontiers in Psychology

Key finding: The goal of this mini-review is three-fold: (1) to summarize the current literature on ADI and its link to cognitive impairment outcomes; (2) suggest possible mechanisms through which ADI may have an impact on AD/ADRD outcomes, and (3) discuss important considerations when studying relations between ADI and cognitive as well as brain health. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Sex differences in plasma p-tau181 associations with Alzheimer's disease biomarkers, cognitive decline, and clinical progression

51/100 ✓ Peer-reviewed Long-term cohort studies Molecular psychiatry

Key finding: Some studies have found that higher levels of tau biomarkers are more strongly associated with clinical AD, cognitive decline and neurodegeneration in women than in men. +3 more findings

• Biomarkers

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A shared disease-associated oligodendrocyte signature among multiple CNS pathologies

43/100 ✓ Peer-reviewed Genetics Nature neuroscience

Key finding: Using quantitative spatial analysis of mouse and postmortem human brain tissues, we found that oligodendrocytes expressing a key DOL marker (SERPINA3N/SERPINA3 accordingly) are present in the cortex in areas of brain damage and are enriched near Aβ plaques.

• Brain Biology

Full summary, score breakdown and related studies → Original source

Four Distinct Subtypes of Alzheimer's Disease Based on Resting-State Connectivity Biomarkers

50/100 ✓ Peer-reviewed Brain scans and imaging Biological psychiatry

Key finding: Individuals with AD were clustered into 4 subtypes reproducibly, which included those with 1) diffuse and mild functional connectivity disruption (subtype 1), 2) predominantly decreased connectivity in the default mode network accompanied by an increase in the prefrontal circuit (subtype 2), 3) predominantly decreased connectivity in the anterior cingulate cortex accompanied by an increase in prefrontal cortex connectivity (subtype 3), and 4) predominantly decreased connectivity in the basal ganglia accompanied by an increase in prefrontal cortex connectivity (subtype 4). +2 more findings

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Functional connectivity correlates of reduced goal-directed behaviors in behavioural variant frontotemporal dementia

41/100 ✓ Peer-reviewed Brain scans and imaging Brain structure & function

Key finding: Apathy in bvFTD was associated with lower time spent in activity combined with walking episodes of higher frequency, lower acceleration and higher duration. +1 more finding

• Other Dementias

Full summary, score breakdown and related studies → Original source

Metacognition, cortical thickness, and tauopathy in aging

50/100 ✓ Peer-reviewed Brain scans and imaging Neurobiology of aging

Key finding: We found that worse performers had lower self-appraisal ratings, but still overestimated their performance, consistent with the Dunning-Kruger effect. +3 more findings

• Brain Scans

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GLP-1 Receptor Agonists in Neurodegeneration: Neurovascular Unit in the Spotlight

43/100 ✓ Peer-reviewed Drug development Cells

Key finding: In this context, a new class of pharmacological agents that achieve improved glycaemic control via the glucagon-like peptide 1 (GLP-1) receptor has attracted significant attention as putative neuroprotective agents. +1 more finding

• Treatments

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Functional Connectivity Dynamics Altered of the Resting Brain in Subjective Cognitive Decline

48/100 ✓ Peer-reviewed Brain scans and imaging Frontiers in aging neuroscience

Key finding: When comparing SCD (N = 40) with NC (N = 45), mdALFFmean decreased at right inferior parietal lobule (IPL) of the frontoparietal network (FPN). +4 more findings

• Early Stage

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The role of triggering receptor expressed on myeloid cells 2 in Parkinson's disease and other neurodegenerative disorders

41/100 ✓ Peer-reviewed TREM2 and immune genetics Behavioural brain research

Key finding: In recent years, triggering factor expressed on myeloid cells (TREM2) gained attention in the field of neurodegeneration as it could be associated with different neurodegenerative disorders.

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source