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Negative affective burden is associated with higher resting-state functional connectivity in subjective cognitive decline
Claudia Schwarz, Gloria S Benson, Daria Antonenko, Nora Horn, Theresa Köbe, Olga Klimecki, Werner Sommer, Miranka Wirth et al.. Scientific reports, 2022-04-13
Topic: Brain imaging, connectivity and assessment
Subjective cognitive decline (SCD), as expressed by older adults, is associated with negative affect, which, in turn, is a likely risk factor for Alzheimer's Disease (AD). This study assessed the associations between negative affective burden, cognitive functioning, and functional connectivity in networks vulnerable to AD in the context of SCD. Older participants (60-90 years) with SCD (n = 51) and healthy controls (n = 50) were investigated in a cross-sectional study. Subclinical negative affective burden, quantified through a composite of self-reported negative affective factors, was related to cognitive functioning (self-perceived and objective) and functional connectivity. Seed-to-voxel analyses were carried out in default mode network (DMN) and salience network (SAL) nodes using resting-state functional magnetic resonance imaging. Greater negative affective burden was associated with lower self-perceived cognitive functioning and lower between-network functional connectivity of DMN and SAL nodes in the total sample. In addition, there was a significant moderation of SCD status. Greater negative affective burden related to higher functional connectivity within DMN (posterior cingulate-to-precuneus) and within SAL (anterior cingulate-to-insula) nodes in the SCD group, whereas in controls the inverse association was found. We show that negative affective burden is associated with functional brain alterations in older adults, regardless of SCD status. Specifically in the SCD phenotype, greater negative affective burden relates to higher functional connectivity within brain networks vulnerable to AD. Our findings imply that negative affective burden should be considered a potentially modifiable target for early intervention.
Key findings
- Subjective cognitive decline (SCD), as expressed by older adults, is associated with negative affect, which, in turn, is a likely risk factor for Alzheimer's Disease (AD).
- Greater negative affective burden was associated with lower self-perceived cognitive functioning and lower between-network functional connectivity of DMN and SAL nodes in the total sample.
- In addition, there was a significant moderation of SCD status.
- We show that negative affective burden is associated with functional brain alterations in older adults, regardless of SCD status.
- Our findings imply that negative affective burden should be considered a potentially modifiable target for early intervention.
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Study details
- Study designcross-sectional
- Participants51
- Evidence strengthLow
How this study scored 55/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 31 of the 56 points we could judge it on, which is 55 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Scientific reports) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 51 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35418579) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 31 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 31 of the 56 points we could judge it on is 55 out of 100. |
| Total | 55 / 100 | — |
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APA 7th
Schwarz, C., Benson, G. S., Antonenko, D., Horn, N., Köbe, T., Klimecki, O., et al. (2022). Negative affective burden is associated with higher resting-state functional connectivity in subjective cognitive decline. Scientific reports. https://doi.org/10.1038/s41598-022-10179-y
Vancouver
Schwarz C, Benson GS, Antonenko D, Horn N, Köbe T, Klimecki O, et al. Negative affective burden is associated with higher resting-state functional connectivity in subjective cognitive decline. Scientific reports. 2022. doi:10.1038/s41598-022-10179-y. PMID: 35418579.
BibTeX
@article{schwarz2022-35418579,
author = {Schwarz, Claudia and Benson, Gloria S and Antonenko, Daria and Horn, Nora and Köbe, Theresa and Klimecki, Olga and Sommer, Werner and Wirth, Miranka and others},
title = {{Negative affective burden is associated with higher resting-state functional connectivity in subjective cognitive decline}},
journal = {Scientific reports},
year = {2022},
doi = {10.1038/s41598-022-10179-y},
pmid = {35418579},
url = {https://doi.org/10.1038/s41598-022-10179-y}
}