Home › Research › Prevention and risk
Variation in Population Attributable Fraction of Dementia Associated With Potentially Modifiable Risk Factors by Race and Ethnicity in the US
Lee M, Whitsel E, Avery C, Hughes TM, Griswold ME, Sedaghat S, Gottesman RF, Mosley TH et al.. JAMA network open, 2022-07-01
Topic: Risk, prevention and care in population studies
Importance Identifying modifiable risk factors that are associated with dementia burden across racial and ethnic groups in the population can yield insights into the potential effectiveness of interventions in preventing dementia and reducing disparities. Objective To calculate the population attributable fraction (PAF) of dementia associated with 12 established modifiable risk factors for all US adults, as well as separately by race and ethnicity. Results Among all US adults, an estimated 41.0% (95% CI, 22.7%-55.9%) of dementia cases were attributable to 12 risk factors. Conclusions and relevance A large fraction of dementia cases in the US were associated with potentially modifiable risk factors, especially for Black and Hispanic individuals.
Key findings
- Importance Identifying modifiable risk factors that are associated with dementia burden across racial and ethnic groups in the population can yield insights into the potential effectiveness of interventions in preventing dementia and reducing disparities.
- Objective To calculate the population attributable fraction (PAF) of dementia associated with 12 established modifiable risk factors for all US adults, as well as separately by race and ethnicity.
- Results Among all US adults, an estimated 41.0% (95% CI, 22.7%-55.9%) of dementia cases were attributable to 12 risk factors.
- Conclusions and relevance A large fraction of dementia cases in the US were associated with potentially modifiable risk factors, especially for Black and Hispanic individuals.
Why it matters
This analysis estimated that 41.0% of dementia cases among all US adults were attributable to 12 risk factors, with a large fraction associated with potentially modifiable risk factors especially for Black and Hispanic individuals. This estimates how much dementia burden is linked to modifiable risk factors and does not show that modifying them prevents dementia.
New to this subject? Start with our plain-English guide: Prevention →
Study details
- Study designsystematic review
- Effect size41.0%; 22.7%; 55.9%
- Evidence strengthHigh
How this study scored 76/100
Published in a leading specialty journal, and it is a systematic review of all the studies on the question. Scored zero for sample size and studied in people because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (JAMA network open) |
| Journal's citation record | 2 / 4 | JAMA Network Open: journal h-index 235 (OpenAlex, 2026-10-29) |
| Study design | 12 / 12 | A systematic review of all the studies on the question |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | 5 / 7 | Cited 177 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 29.5 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 5 / 6 | Cited 21.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 39 other studies in this library |
| Still being cited | 3 / 4 | Cited 137 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Pamela L. Lutsey: h-index 79 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | National Institutes of Health: institution h-index 2,723 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35793088) |
| Free to read | 2 / 2 | Free to read |
| Total | 76 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1001/jamanetworkopen.2022.19672
- PubMed: 35793088
- Original source →
- Free full text: JAMA Network Open →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Lee, M., Whitsel, E., Avery, C., Hughes, T. M., Griswold, M. E., Sedaghat, S., et al. (2022). Variation in Population Attributable Fraction of Dementia Associated With Potentially Modifiable Risk Factors by Race and Ethnicity in the US. JAMA network open. https://doi.org/10.1001/jamanetworkopen.2022.19672
Vancouver
Lee M, Whitsel E, Avery C, Hughes TM, Griswold ME, Sedaghat S, et al. Variation in Population Attributable Fraction of Dementia Associated With Potentially Modifiable Risk Factors by Race and Ethnicity in the US. JAMA network open. 2022. doi:10.1001/jamanetworkopen.2022.19672. PMID: 35793088.
BibTeX
@article{lee2022-35793088,
author = {Lee, M. and Whitsel, E. and Avery, C. and Hughes, T. M. and Griswold, M. E. and Sedaghat, S. and Gottesman, R. F. and Mosley, T. H. and others},
title = {{Variation in Population Attributable Fraction of Dementia Associated With Potentially Modifiable Risk Factors by Race and Ethnicity in the US}},
journal = {JAMA network open},
year = {2022},
doi = {10.1001/jamanetworkopen.2022.19672},
pmid = {35793088},
url = {https://doi.org/10.1001/jamanetworkopen.2022.19672}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Later studies that cite this one
39 studies in the alzhub library list this one in their references. Showing the 8 highest-scoring.
Related studies in Prevention and risk
Also tagged “biobank”
1,084 studies in the library carry the topic tag “biobank”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 1,084 tagged studies.