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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 9,951–9,975 of 27,380 studies, newest first · page 399 of 1096.

July 2021 25

  1. 2021-07-31

    Exploring ER stress response in cellular aging and neuroinflammation in Alzheimer's disease

    ✓ Peer-reviewed Disease mechanisms Ageing research reviews

    Key finding: Aging is associated with changes in the expression of ER chaperones and folding enzymes, leading to the impairment of proteostasis, and accumulation of misfolded proteins. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2021-07-31

    Inflammation and Alzheimer's Disease: Mechanisms and Therapeutic Implications by Natural Products

    ✓ Peer-reviewed Inflammation and the immune system Mediators of inflammation

    Key finding: Amyloid-beta has been extensively studied and targeted to develop an effective disease-modifying therapy, but the success rate in clinical practice is minimal. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2021-07-31

    Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice

    ✓ Peer-reviewed TREM2 and immune genetics Brain, behavior, and immunity

    Key finding: Chronic stress can influence all organs via the secretion of stress hormones, including glucocorticoids by the adrenal glands, which coordinate the stress response across the body. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-07-30

    Novel Therapeutic Approaches for Alzheimer's Disease: An Updated Review

    ✓ Peer-reviewed Treatments International journal of molecular sciences

    Key finding: Finding novel treatments for AD has become urgent. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2021-07-30

    A Randomized Controlled Trial Investigating the Feasibility of a Low-Intensity Psychological Intervention for Fear of Memory Loss and Quality of Life in Older Adults: Protocol for the Reducing Fear and Avoidance of Memory Loss (REFRAME) Study

    ✓ Peer-reviewed Treatments JMIR research protocols

    Key finding: Trial registration ClinicalTrials.gov NCT04821960; https://clinicaltrials.gov/ct2/show/NCT04821960. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2021-07-29

    Discovery of Parkinson's disease states and disease progression modelling: a longitudinal data study using machine learning

    ✓ Peer-reviewed Digital health tools The Lancet. Digital health

    Key finding: The results were validated in an independent sample of 610 patients with Parkinson's disease from the National Institute of Neurological Disorders and Stroke Parkinson's Disease Biomarker Program (PDBP). +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2021-07-28

    Variability in the type and layer distribution of cortical Aβ pathology in familial Alzheimer's disease

    ✓ Peer-reviewed Risk genes beyond APOE Brain pathology (Zurich, Switzerland)

    Key finding: In this cohort, possession of an APOE4 allele was associated with increased disease duration but not with age at onset, after adjusting for mutation sub-group and sex. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2021-07-28

    NLRP3 inflammasome activation and cell death

    ✓ Peer-reviewed Risk factors Cellular & molecular immunology

    Key finding: However, aberrant activation of the NLRP3 inflammasome is associated with the pathogenesis of various inflammatory diseases, such as diabetes, cancer, and Alzheimer's disease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2021-07-28

    Subjective cognitive decline higher among sexual and gender minorities in the United States, 2015-2018

    ✓ Peer-reviewed Disparities Alzheimer's & dementia (New York, N. Y.)

    Key finding: Higher prevalence of SCD in SGM adults highlights the importance of ensuring inclusive screenings, interventions, care services, and resources for SGM adults.

    Full summary, score breakdown and related studies → Original source

  10. 2021-07-27

    Interplay between Brain Pericytes and Endothelial Cells in Dementia

    ✓ Peer-reviewed Clinical safety The American journal of pathology

    Key finding: Disruption of the BBB in dementia precipitates cognitive decline. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2021-07-27

    Genetically Determined Chronic Low-Grade Inflammation and Hundreds of Health Outcomes in the UK Biobank and the FinnGen Population: A Phenome-Wide Mendelian Randomization Study

    ✓ Peer-reviewed Long-term cohort studies Frontiers in immunology

    Key finding: We aimed to determine whether genetically determined CRP was associated with hundreds of human phenotypes to guide anti-inflammatory interventions. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2021-07-27

    Global mortality from dementia: Application of a new method and results from the Global Burden of Disease Study 2019

    ✓ Peer-reviewed Caregiving Alzheimer's & dementia (New York, N. Y.)

    Key finding: Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2021-07-27

    Mini-Mental State Examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI)

    ✓ Peer-reviewed Getting a diagnosis The Cochrane database of systematic reviews

    Key finding: The Mini-Mental State Examination (MMSE) is the best-known and the most often used short screening tool for providing an overall measure of cognitive impairment in clinical, research and community settings. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2021-07-27

    Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease

    ✓ Peer-reviewed Biomarkers Autophagy

    Key finding: Abbreviations Aβ: β-amyloid; AD: Alzheimer disease; AIF1/IBA1: allograft inflammatory factor 1; ALP: autophagy-lysosomal pathway; APP: amyloid beta precursor protein; ATP6V1B1/V-ATPase V1b1: ATPase H+ transporting V1 subunit B1; AVs: autophagy vacuoles; BAF: bafilomycin A 1 ; CFC: contextual/cued fear conditioning assay; CHX: Ca 2+ /H + exchanger; CTF-β: carboxy-terminal fragment derived from β-secretase; CTSD: cathepsin D; fAD: familial Alzheimer disease; GFAP: glial fibrillary acidic protein; LAMP1: lysosomal associated membrane protein 1; LTP: long-term potentiation; MCOLN1/TRPML1: mucolipin 1; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MAPT: microtubule associated protein tau; MWM: Morris water maze; NFT: neurofibrillary tangles; PFC: prefrontal cortex; PSEN1: presenilin 1; SQSTM1/p62: sequestosome 1; TBS: theta burst stimulation; TEM: transmission electronic microscopy; TPCN2/TPC2: two pore segment channel 2; WT: wild-type; V-ATPase: vacuolar type H + -ATPase.

    Full summary, score breakdown and related studies → Original source

  15. 2021-07-26

    Repetitive Traumatic Brain Injury Among Older Adults

    ✓ Peer-reviewed Costs and economics The Journal of head trauma rehabilitation

    Key finding: A total of 38 064 older Medicare beneficiaries experienced a TBI. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2021-07-26

    Bilingual experience and intrinsic functional connectivity in adults, aging, and Alzheimer's disease

    ✓ Peer-reviewed Brain scans and imaging Annals of the New York Academy of Sciences

    Key finding: Altered RSFC in language and control networks subsequent to L2 training programs also is associated with improved global cognition in older adults.

    Full summary, score breakdown and related studies → Original source

  17. 2021-07-26

    The Role of 18F-Flortaucipir (AV-1451) in the Diagnosis of Neurodegenerative Disorders

    ✓ Peer-reviewed Brain scans and imaging Cureus

    Key finding: We concluded that although the role of 18F-AV-1451 seems promising in the neuroimaging of AD, the benefit appears uncertain when it comes to the non-Alzheimer's tauopathies.

    Full summary, score breakdown and related studies → Original source

  18. 2021-07-26

    Comparison of CSF phosphorylated tau 181 and 217 for cognitive decline

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: CSF p-tau217 was superior to p-tau181 for the diagnosis of Alzheimer's disease (AD) pathology. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2021-07-26

    Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype

    ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: We evaluated whether insomnia symptom severity was associated with cognitive function, and whether this relationship was modified by biomarkers associated with Alzheimer's disease risk. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2021-07-26

    Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study

    ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: No large-scale characterizations of neurofilament light chain (NfL) have been conducted in diverse populations.

    Full summary, score breakdown and related studies → Original source

  21. 2021-07-25

    Emerging roles of oxidative stress in brain aging and Alzheimer's disease

    ✓ Peer-reviewed Prevention trials Neurobiology of aging

    Key finding: Emerging evidence suggests that accumulated oxidative stress may be one of the key mechanisms causing cognitive aging and neurodegenerative diseases such as Alzheimer's disease (AD).

    Full summary, score breakdown and related studies → Original source

  22. 2021-07-23

    Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study

    ✓ Peer-reviewed Genetics Frontiers in aging neuroscience

    Key finding: There are numerous models that have been generated to study Alzheimer's disease (AD) and the underlying pathogenesis of the disease. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2021-07-23

    Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores

    ✓ Peer-reviewed Genetics Nature communications

    Key finding: However, there is little agreement in the field as to what approach should be used for genetic risk score calculations, how to model the effect of APOE, what the optimal p-value threshold (pT) for SNP selection is and how to compare scores between studies and methods. +4 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2021-07-23

    Cognitive deficits in people who have recovered from COVID-19

    ✓ Peer-reviewed How common it is EClinicalMedicine

    Key finding: People who had recovered from COVID-19, including those no longer reporting symptoms, exhibited significant cognitive deficits versus controls when controlling for age, gender, education level, income, racial-ethnic group, pre-existing medical disorders, tiredness, depression and anxiety. +1 more finding

    Full summary, score breakdown and related studies → Original source

  25. 2021-07-23

    Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer's disease

    ✓ Peer-reviewed Genetics Molecular neurodegeneration

    Key finding: These results indicate lipid droplet accumulation occurs in human DAM xMGs in AD, but is reduced in TREM2-R47H DAM xMGs, as it occurs secondary to TREM2-mediated changes in plaque proximity and reactivity. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →