Home › Research › Brain scans and imaging
Four Distinct Subtypes of Alzheimer's Disease Based on Resting-State Connectivity Biomarkers
Pindong Chen, Hongxiang Yao, Betty M Tijms, Pan Wang, Dawei Wang, Chengyuan Song, Hongwei Yang, Zengqiang Zhang et al.. Biological psychiatry, 2022-06-26
Topic: Brain imaging, connectivity and assessment
Individuals with AD were clustered into 4 subtypes reproducibly, which included those with 1) diffuse and mild functional connectivity disruption (subtype 1), 2) predominantly decreased connectivity in the default mode network accompanied by an increase in the prefrontal circuit (subtype 2), 3) predominantly decreased connectivity in the anterior cingulate cortex accompanied by an increase in prefrontal cortex connectivity (subtype 3), and 4) predominantly decreased connectivity in the basal ganglia accompanied by an increase in prefrontal cortex connectivity (subtype 4). In addition to these differences in functional connectivity, differences between the AD subtypes were found in cognition, structural measures, and cognitive decline patterns. These comprehensive results offer new insights that may advance precision medicine for AD and facilitate strategies for future clinical trials.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Chen, P., Yao, H., Tijms, B. M., Wang, P., Wang, D., Song, C., et al. (2023). Four Distinct Subtypes of Alzheimer's Disease Based on Resting-State Connectivity Biomarkers. Biological psychiatry. https://doi.org/10.1016/j.biopsych.2022.06.019
Vancouver
Chen P, Yao H, Tijms BM, Wang P, Wang D, Song C, et al. Four Distinct Subtypes of Alzheimer's Disease Based on Resting-State Connectivity Biomarkers. Biological psychiatry. 2023. doi:10.1016/j.biopsych.2022.06.019. PMID: 36137824.
BibTeX
@article{chen2023-36137824,
author = {Chen, Pindong and Yao, Hongxiang and Tijms, Betty M and Wang, Pan and Wang, Dawei and Song, Chengyuan and Yang, Hongwei and Zhang, Zengqiang and others},
title = {{Four Distinct Subtypes of Alzheimer's Disease Based on Resting-State Connectivity Biomarkers}},
journal = {Biological psychiatry},
year = {2023},
doi = {10.1016/j.biopsych.2022.06.019},
pmid = {36137824},
url = {https://doi.org/10.1016/j.biopsych.2022.06.019}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Individuals with AD were clustered into 4 subtypes reproducibly, which included those with 1) diffuse and mild functional connectivity disruption (subtype 1), 2) predominantly decreased connectivity in the default mode network accompanied by an increase in the prefrontal circuit (subtype 2), 3) predominantly decreased connectivity in the anterior cingulate cortex accompanied by an increase in prefrontal cortex connectivity (subtype 3), and 4) predominantly decreased connectivity in the basal ganglia accompanied by an increase in prefrontal cortex connectivity (subtype 4).
- In addition to these differences in functional connectivity, differences between the AD subtypes were found in cognition, structural measures, and cognitive decline patterns.
- These comprehensive results offer new insights that may advance precision medicine for AD and facilitate strategies for future clinical trials.
New to this subject? Start with our plain-English guide: Brain scans & tests →
Study details
- Participants809
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 28 of the 56 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Biological psychiatry) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 809 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36137824) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 28 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 28 of the 56 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Free copy unknown: no free-copy check has an answer for this record yet. That does not mean it is paywalled.
Related
Studies in the library that share something with this one. The line above each title says what.
Related studies in Brain scans and imaging
Also tagged “networks”
187 studies in the library carry the topic tag “networks”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 187 tagged studies.