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The Alzheimer's Association appropriate use recommendations for blood biomarkers in Alzheimer's disease
Oskar Hansson, Rebecca M. Edelmayer, Adam L. Boxer, María C. Carrillo, Michelle M. Mielke, Gil D. Rabinovici, Stephen Salloway, Reisa Anne Sperling, Henrik Zetterberg, Charlotte Elisabeth Teunissen. Alzheimer s & Dementia, 2022-07-31
Topic: Amyloid, tau and blood-test diagnosis
Blood-based markers (BBMs) have recently shown promise to revolutionize the diagnostic and prognostic work-up of Alzheimer's disease (AD), as well as to improve the design of interventional trials. Here we discuss in detail further research needed to be performed before widespread use of BBMs. We already now recommend use of BBMs as (pre-)screeners to identify individuals likely to have AD pathological changes for inclusion in trials evaluating disease-modifying therapies, provided the AD status is confirmed with positron emission tomography (PET) or cerebrospinal fluid (CSF) testing. We also encourage studying longitudinal BBM changes in ongoing as well as future interventional trials. However, BBMs should not yet be used as primary endpoints in pivotal trials. Further, we recommend to cautiously start using BBMs in specialized memory clinics as part of the diagnostic work-up of patients with cognitive symptoms and the results should be confirmed whenever possible with CSF or PET. Additional data are needed before use of BBMs as stand-alone diagnostic AD markers, or before considering use in primary care.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Hansson, O., Edelmayer, R. M., Boxer, A. L., Carrillo, M. C., Mielke, M. M., Rabinovici, G. D., et al. (2022). The Alzheimer's Association appropriate use recommendations for blood biomarkers in Alzheimer's disease. Alzheimer s & Dementia. https://doi.org/10.1002/alz.12756
Vancouver
Hansson O, Edelmayer RM, Boxer AL, Carrillo MC, Mielke MM, Rabinovici GD, et al. The Alzheimer's Association appropriate use recommendations for blood biomarkers in Alzheimer's disease. Alzheimer s & Dementia. 2022. doi:10.1002/alz.12756. PMID: 35908251.
BibTeX
@article{hansson2022-35908251,
author = {Hansson, Oskar and Edelmayer, Rebecca M. and Boxer, Adam L. and Carrillo, María C. and Mielke, Michelle M. and Rabinovici, Gil D. and Salloway, Stephen and Sperling, Reisa Anne and Zetterberg, Henrik and Teunissen, Charlotte Elisabeth},
title = {{The Alzheimer's Association appropriate use recommendations for blood biomarkers in Alzheimer's disease}},
journal = {Alzheimer s \& Dementia},
year = {2022},
doi = {10.1002/alz.12756},
pmid = {35908251},
url = {https://doi.org/10.1002/alz.12756}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 10 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Why it matters
Alzheimer's Association recommendations on blood tests for Alzheimer's disease. For now they recommend blood biomarkers as pre-screeners for trial entry, with Alzheimer's status confirmed by PET or spinal fluid (CSF) testing, and cautious use in specialized memory clinics with confirmation where possible. More data are needed before they are used as stand-alone diagnostic tests or in primary care.
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How this study scored 60/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 57 of the 95 points we could judge it on, which is 60 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer s & Dementia) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 605 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 100.8 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 6 / 6 | Cited 70.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 4 / 4 | Cited 464 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Charlotte Elisabeth Teunissen: h-index 116 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 19 institution(s) in 4 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35908251) |
| Free to read | 2 / 2 | Free to read |
| Points | 57 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 57 of the 95 points we could judge it on is 60 out of 100. |
| Total | 60 / 100 | — |
What each of these 20 components measures, and what this score is not →
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