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Worldwide prevalence of mild cognitive impairment among community dwellers aged 50 years and older: a meta-analysis and systematic review of epidemiology studies
Bai W, Chen P, Cai H, Zhang Q, Su Z, Cheung T, Jackson T, Sha S et al.. Age and ageing, 2022-08-01
Topic: Risk, prevention and care in population studies
Background Mild cognitive impairment (MCI) is the preclinical and transitional stage between healthy ageing and dementia that may be a potential 'target' for interventions designed to delay progression to dementia. In this systematic review and meta-analysis, we assessed the prevalence of MCI worldwide in community-dwelling adults aged 50 years and older. Methods PubMed, Web of Science, Embase and PsycINFO database searches were conducted from their respective inception dates to 1 September 2021. Data on the overall prevalence of MCI were synthesised using random effects models. Results A total of 66 articles covering 242,804 participants fulfilled study criteria for inclusion. The overall prevalence of MCI was 15.56% (95%CI: 13.24-18.03%). Prevalence rates of amnestic MCI and non-amnestic MCI were 10.03% (95%CI: 7.98-12.27%) and 8.72% (95%CI: 6.78-10.89%), respectively. The prevalence of MCI increased with age and decreased with education level. Subgroup and meta-regression analyses revealed that region of study site and male gender proportion per sample were significant correlates of MCI prevalence. Conclusion The global prevalence of MCI among community dwellers is over 15% and is affected by age, gender, education level and region of study sites. Assessment and interventions targeting MCI within at-risk population subgroups should be considered toward the prevention of dementia.
Key findings
- Data on the overall prevalence of MCI were synthesised using random effects models.
- Results A total of 66 articles covering 242,804 participants fulfilled study criteria for inclusion.
- The overall prevalence of MCI was 15.56% (95%CI: 13.24-18.03%).
- Subgroup and meta-regression analyses revealed that region of study site and male gender proportion per sample were significant correlates of MCI prevalence.
Why it matters
This systematic review and meta-analysis found the overall global prevalence of mild cognitive impairment among community dwellers aged 50 and older was 15.56%. Prevalence increased with age and decreased with education level, and the authors say assessment and interventions targeting mild cognitive impairment within at-risk subgroups should be considered toward dementia prevention.
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Study details
- Study designsystematic review
- Participants242,804
- Effect size15.56%; 18.03%; 10.03%
- Evidence strengthHigh
How this study scored 80/100
Published in a peer-reviewed journal, and it is a systematic review of all the studies on the question. We have no data on journal's citation record, so that was left out: it earned 77 of the 96 points we could judge it on, which is 80 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Age and ageing) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 12 / 12 | A systematic review of all the studies on the question |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 4 / 4 | 242,804 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | 6 / 7 | Cited 398 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 66.3 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 6 / 6 | Cited 49.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 11 other studies in this library |
| Still being cited | 4 / 4 | Cited 354 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Yu‐Tao Xiang: h-index 87 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Hong Kong Polytechnic University: institution h-index 668 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35977150) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 77 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 77 of the 96 points we could judge it on is 80 out of 100. |
| Total | 80 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Bai, W., Chen, P., Cai, H., Zhang, Q., Su, Z., Cheung, T., et al. (2022). Worldwide prevalence of mild cognitive impairment among community dwellers aged 50 years and older: a meta-analysis and systematic review of epidemiology studies. Age and ageing. https://doi.org/10.1093/ageing/afac173
Vancouver
Bai W, Chen P, Cai H, Zhang Q, Su Z, Cheung T, et al. Worldwide prevalence of mild cognitive impairment among community dwellers aged 50 years and older: a meta-analysis and systematic review of epidemiology studies. Age and ageing. 2022. doi:10.1093/ageing/afac173. PMID: 35977150.
BibTeX
@article{bai2022-35977150,
author = {Bai, W. and Chen, P. and Cai, H. and Zhang, Q. and Su, Z. and Cheung, T. and Jackson, T. and Sha, S. and others},
title = {{Worldwide prevalence of mild cognitive impairment among community dwellers aged 50 years and older: a meta-analysis and systematic review of epidemiology studies}},
journal = {Age and ageing},
year = {2022},
doi = {10.1093/ageing/afac173},
pmid = {35977150},
url = {https://doi.org/10.1093/ageing/afac173}
}
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