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Clinical course and serum amyloid β levels in elderly patients with major depressive disorder
Shuntaro Natsume, Hajime Baba, Hitoshi Maeshima, Takao Saida, Naoto Yoshinari, Kentaro Shimizu, Toshihito Suzuki. Journal of affective disorders, 2022-08-03
Topic: Plasma and spinal-fluid biomarkers
The analysis revealed decreased Aβ42 levels and increased Aβ42/40 ratios in elderly patients with depression at admission compared with healthy subjects. These changes in the acute phase of depression were not normalized immediately after remission; however, they recovered to healthy levels 1 year after remission. LIMITATIONS: There is a possibility that the results may be influenced by antidepressants. These results suggest that altered Aβ metabolism caused by depression may ameliorate, although after a lengthy period of time after remission. Our findings also suggest that the AD-related pathological changes caused or increased by depression can be reduced by maintaining remission for an extended period of time.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Natsume, S., Baba, H., Maeshima, H., Saida, T., Yoshinari, N., Shimizu, K., et al. (2022). Clinical course and serum amyloid β levels in elderly patients with major depressive disorder. Journal of affective disorders. https://doi.org/10.1016/j.jad.2022.07.073
Vancouver
Natsume S, Baba H, Maeshima H, Saida T, Yoshinari N, Shimizu K, et al. Clinical course and serum amyloid β levels in elderly patients with major depressive disorder. Journal of affective disorders. 2022. doi:10.1016/j.jad.2022.07.073. PMID: 35932935.
BibTeX
@article{natsume2022-35932935,
author = {Natsume, Shuntaro and Baba, Hajime and Maeshima, Hitoshi and Saida, Takao and Yoshinari, Naoto and Shimizu, Kentaro and Suzuki, Toshihito},
title = {{Clinical course and serum amyloid β levels in elderly patients with major depressive disorder}},
journal = {Journal of affective disorders},
year = {2022},
doi = {10.1016/j.jad.2022.07.073},
pmid = {35932935},
url = {https://doi.org/10.1016/j.jad.2022.07.073}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- The analysis revealed decreased Aβ42 levels and increased Aβ42/40 ratios in elderly patients with depression at admission compared with healthy subjects.
- These changes in the acute phase of depression were not normalized immediately after remission; however, they recovered to healthy levels 1 year after remission.
- LIMITATIONS: There is a possibility that the results may be influenced by antidepressants.
- These results suggest that altered Aβ metabolism caused by depression may ameliorate, although after a lengthy period of time after remission.
- Our findings also suggest that the AD-related pathological changes caused or increased by depression can be reduced by maintaining remission for an extended period of time.
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 23 of the 56 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of affective disorders) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35932935) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 23 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 23 of the 56 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
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